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Open AccessThe thioesterase APT1 is a bidirectional-adjustment redox sensor
The adjustment of cellular redox homeostasis is essential in when responding to environmental perturbations, and the mechanism by which cells distinguish between normal and oxidized states through sensors is a...
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Article
Open AccessIntegrated analysis for treatment scheme of sodium–glucose cotransporter 2 inhibitors in patients with diabetic kidney disease: a real-world study
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are recommended for type 2 diabetes mellitus patients with impaired renal function, but the actual situation of SGLT2i using is unclear. Therefore, in this re...
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Open AccessSustainable methane utilization technology via photocatalytic halogenation with alkali halides
Methyl halides are versatile platform molecules, which have been widely adopted as precursors for producing value-added chemicals and fuels. Despite their high importance, the green and economical synthesis of...
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Open AccessN6-methyladenosine RNA modification regulates photosynthesis during photodamage in plants
N6-methyladenosine (m6A) modification of mRNAs affects many biological processes. However, the function of m6A in plant photosynthesis remains unknown. Here, we demonstrate that m6A modification is crucial for ph...
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Open AccessPangenomic analysis of Chinese gastric cancer
Pangenomic study might improve the completeness of human reference genome (GRCh38) and promote precision medicine. Here, we use an automated pipeline of human pangenomic analysis to build gastric cancer pan-ge...
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Open AccessA test-retest resting, and cognitive state EEG dataset during multiple subject-driven states
Here we present a test-retest dataset of electroencephalogram (EEG) acquired at two resting (eyes open and eyes closed) and three subject-driven cognitive states (memory, music, subtraction) with both short-te...
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Article
Open AccessExperimental demonstration of adversarial examples in learning topological phases
Classification and identification of different phases and the transitions between them is a central task in condensed matter physics. Machine learning, which has achieved dramatic success in a wide range of ap...
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Open AccessTranscriptome analysis of halophyte Nitraria tangutorum reveals multiple mechanisms to enhance salt resistance
As a typical halophyte, Nitraria tangutorum Bobr. has attracted the interest of many researchers with the excellent salt tolerance. Elucidation of the mechanism of N. tangutorum salinity tolerance will facilitate...
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Open AccessDifferential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model
Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19), with macrophages as one of the main cell types involved. It is urgent to understand the interacti...
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Open AccessSingle-crystal two-dimensional material epitaxy on tailored non-single-crystal substrates
The use of single-crystal substrates as templates for the epitaxial growth of single-crystal overlayers has been a primary principle of materials epitaxy for more than 70 years. Here we report our finding that...
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Open AccessLight-induced dimension crossover dictated by excitonic correlations
In low-dimensional systems with strong electronic correlations, the application of an ultrashort laser pulse often yields novel phases that are otherwise inaccessible. The central challenge in understanding su...
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Open AccessAusTraits, a curated plant trait database for the Australian flora
We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field camp...
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Open AccessTwelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples ...
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Article
Optical manipulation of electronic dimensionality in a quantum material
Exotic phenomena can be achieved in quantum materials by confining electronic states into two dimensions. For example, relativistic fermions are realized in a single layer of carbon atoms1, the quantized Hall eff...
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Open AccessEpidemiological survey of human echinococcosis in east Gansu, China
Echinococcosis is endemic in pastoral regions of south, west and mid-Gansu province, China. The present study aimed to determine the prevalence of echinococcosis in east Gansu, and analyze its associated risk ...
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Open AccessA combinatory ferroelectric compound bridging simple ABO3 and A-site-ordered quadruple perovskite
The simple ABO3 and A-site-ordered AA′3B4O12 perovskites represent two types of classical perovskite functional materials. There are well-known simple perovskites with ferroelectric properties, while there is sti...
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Open AccessIon adsorption-induced reversible polarization switching of a van der Waals layered ferroelectric
Solid-liquid interface is a key concept of many research fields, enabling numerous physical phenomena and practical applications. For example, electrode-electrolyte interfaces with electric double layers have ...
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Open AccessEnvironmentally favorable magnesium phosphate anti-corrosive coating on carbon steel and protective mechanisms
Polymer coatings are commonly used to protect carbon steels from corrosion but they are susceptible to weathering and many of them have environmental concerns. Therefore, we studied the possibility of an envir...
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Identification of SARS-CoV-2 inhibitors using lung and colonic organoids
There is an urgent need to create novel models using human disease-relevant cells to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) biology and to facilitate drug screening. Here, as SARS-C...
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Open AccessCCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer
The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the KrasLSL−G12...