60 Result(s)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

The combination of immune checkpoint blockade (ICB) with chemotherapy significantly improves clinical benefit of cancer treatment. Since chemotherapy is often associated with adverse events, concomitant treatm...

**nxin **ong, Siyu Chen, Jianfei Shen, Hua You… in Signal Transduction and Targeted Therapy (2022)

Article

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...

Qing-zhang Tuo, Yu Liu, … in Signal Transduction and Targeted Therapy (2022)

Article

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to m...

Yan Yu, **ao-Dan Peng, **ao-Jun Qian… in Signal Transduction and Targeted Therapy (2021)

Article

The way of SARS-CoV-2 vaccine development: success and challenges

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several ha...

Yetian Dong, Tong Dai, Bin Wang, Lei Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

Risk factors and outcomes of diffuse alveolar haemorrhage after allogeneic haematopoietic stem cell transplantation

Diffuse alveolar haemorrhage (DAH) is a life-threatening pulmonary complication occurring after allogeneic haematopoietic stem cell transplantation (allo-HSCT) without an explicit aetiology or a standard treat...

** Wu, Hai-**a Fu, Yun He, **ao-Dong Mo, **ao Liu, Xuan Cai… in Bone Marrow Transplantation (2021)

Article

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu… in Signal Transduction and Targeted Therapy (2021)

Article

Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway

We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the tr...

Shaobin Huang, Wuguo Deng, Peng Wang, Yue Yan, Chuanbo **e, **aoling Cao… in Oncogene (2021)

Article

BCL9 regulates CD226 and CD96 checkpoints in CD8⁺ T cells to improve PD-1 response in cancer

To date, the overall response rate of PD-1 blockade remains unsatisfactory, partially due to limited understanding of tumor immune microenvironment (TIME). B-cell lymphoma 9 (BCL9), a key transcription co-acti...

Mei Feng, Zhongen Wu, Yan Zhou, Zhuang Wei… in Signal Transduction and Targeted Therapy (2021)

Article

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

Pancreatic cancer is an increasingly common cause of cancer mortality with a tight correspondence between disease mortality and incidence. Furthermore, it is usually diagnosed at an advanced stage with a very ...

Shun Wang, Yan Zheng, Feng Yang, Le Zhu… in Signal Transduction and Targeted Therapy (2021)

Article

GPR160 is a potential biomarker associated with prostate cancer

Wan**g Guo, Junyu Zhang, Yan Zhou… in Signal Transduction and Targeted Therapy (2021)

Article

Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3

Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely unknown. Exosomes released by tumor cells have been pro...

Haoting Sun, Chaoqun Wang, Beiyuan Hu… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity

Nitrogen mustard (NM) causes severe vesicating skin injury, which lacks effective targeted therapies. The major limitation is that the specific mechanism of NM-induced skin injury is not well understood. Recen...

Mingliang Chen, Xunhu Dong, Haoyue Deng… in Signal Transduction and Targeted Therapy (2021)