948 Result(s)
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The multimodality cell segmentation challenge: toward universal solutions
Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to ...
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Open AccessStructural insights into human exon-defined spliceosome prior to activation
Spliceosome is often assembled across an exon and undergoes rearrangement to span a neighboring intron. Most states of the intron-defined spliceosome have been structurally characterized. However, the structur...
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Open AccessIn vitro generation of genetic diversity for directed evolution by error-prone artificial DNA synthesis
Generating genetic diversity lies at the heart of directed evolution which has been widely used to engineer genetic parts and gene circuits in synthetic biology. With the ever-expanding application of directed...
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Open AccessThe bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinoma
Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial synthesis in the gastrointestinal tract, reaches distantly located cancer cells, and influences their behavior. LCA w...
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Open AccessInduced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors
Multiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, the simultaneous c...
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Open AccessThe role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis
Colorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression. ...
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Open AccessThe mechanoreceptor Piezo is required for spermatogenesis in Bombyx mori
The animal sperm shows high diversity in morphology, components, and motility. In the lepidopteran model insect, the silkworm Bombyx mori, two types of sperm, including nucleate fertile eupyrene sperm and anuclea...
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Open AccessGenome-wide detections for runs of homozygosity and selective signatures reveal novel candidate genes under domestication in chickens
Indigenous chickens were developed through a combination of natural and artificial selection; essentially, changes in genomes led to the formation of these modern breeds via admixture events. However, their co...
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Open AccessGenome-wide association analysis explores the genetic loci of amino acid content in duck’s breast muscle
Amino acids are the basic components of protein and an important index to evaluate meat quality. With the rapid development of genomics, candidate regions and genes affecting amino acid content in livestock an...
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Open AccessMercury contamination is an invisible threat to declining migratory shorebirds along the East Asian-Australasian Flyway
Exposure to pollutants is a potentially crucial but overlooked driver of population declines in shorebirds along the East Asian-Australasian Flyway. We combined knowledge of moult strategy and life history wit...
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Open AccessDifferences in archaeal diversity and potential ecological functions between saline and hypersaline lakes on Qinghai-Tibet Plateau were driven by multiple environmental and non-environmental factors beyond the salinity
Saline lakes are home to various archaea that play special and crucial roles in the global biogeochemical cycle. The Qinghai-Tibet Plateau hosts a large number of lakes with diverse salinity ranging from 0.1 t...
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Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis
Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet develo** a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptom...
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Genetically optimizing soybean nodulation improves yield and protein content
Symbiotic nitrogen fixation in legume nodules requires substantial energy investment from host plants, and soybean (Glycine max (L.) supernodulation mutants show stunting and yield penalties due to overconsumptio...
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A spatial transcriptome map of the develo** maize ear
A comprehensive understanding of inflorescence development is crucial for crop genetic improvement, as inflorescence meristems give rise to reproductive organs and determine grain yield. However, dissecting in...
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Open AccessMachine learning assists prediction of genes responsible for plant specialized metabolite biosynthesis by integrating multi-omics data
Plant specialized (or secondary) metabolites (PSM), also known as phytochemicals, natural products, or plant constituents, play essential roles in interactions between plants and environment. Although many res...
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Open AccessGATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer
Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined by a few transcription factors including GATA3. We previously reported...
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Open AccessANXA9 facilitates S100A4 and promotes breast cancer progression through modulating STAT3 pathway
Breast cancer has the highest global incidence and mortality rates among all cancer types. Abnormal expression of the Annexin family has been observed in different malignant tumors, including upregulated ANXA9...
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Open AccessAn oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these cells are numerically scarce and functionally exhausted in the tumor microenvironment (TM...
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Open AccessImpacts of longitudinal water curtain cooling system on transcriptome-related immunity in ducks
The closed poultry houses integrated with a longitudinal water curtain cooling system (LWCCS) are widely used in modern poultry production. This study showed the variations in environmental conditions in close...
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Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPα
Pioneer transcription factors are vital for cell fate changes. PU.1 and C/EBPα work together to regulate hematopoietic stem cell differentiation. However, how they recognize in vivo nucleosomal DNA targets rem...
