216 Result(s)

Article

NLRP3–GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice

Perioperative neurocognitive disorders (PND), such as delirium and cognitive impairment, are commonly encountered complications in aged patients. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is a...

Lu-Ying Wang, Xu-Peng Wang, **-Meng Lv, Yu-Dong Shan… in Journal of Neuroinflammation (2023)

Article

Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy

Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acut...

Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du… in Journal of Neuroinflammation (2023)

Article

Correction to: Consensus Paper: Ataxic Gait

Pierre Cabaraux, Sunil K. Agrawal, Huaying Cai, Rocco Salvatore Calabro… in The Cerebellum (2023)

Article

Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2

The Dandy–Walker malformation (DWM) is characterized by neuron dysregulation in embryonic development; however, the regulatory mechanisms associated with it are unclear. This study aimed to investigate the rol...

Fang Fu, Chen Chen, Kun Du, Lu-shan Li, Ru Li, Ting-ying Lei… in Molecular Neurobiology (2023)

Article

Computational complexity drives sustained deliberation

Economic deliberations are slow, effortful and intentional searches for solutions to difficult economic problems. Although such deliberations are critical for making sound decisions, the underlying reasoning s...

Tao Hong, William R. Stauffer in Nature Neuroscience (2023)

Article

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems. The hypothesis of monoamine neu...

Huiyang Liu, **aomei Zhang, Peng Shi, Jiyuan Yuan… in Journal of Neuroinflammation (2023)

Article

Correction to: Protective Effects of Chinese Herbal Medicine Rhizoma drynariae in Rats After Traumatic Brain Injury and Identification of Active Compound

Wenzhu Wang, Haigang Li, **tao Yu, Michael Hong, **g Zhou… in Molecular Neurobiology (2023)

Article

A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis

Despite considerable efforts, ischemic stroke (IS) remains a challenging clinical problem. Therefore, the discovery of effective therapeutic and targeted drugs based on the underlying molecular mechanism is cr...

Yilin Li, Tao **, Naixin Liu, Junsong Wang, Zihan Qin… in Journal of Neuroinflammation (2023)

Article

Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study

Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative cerebrospinal fluid (CSF) fungal cultures after optimal treatme...

Zhikai Wan, Ran Tao, Jiang** Hui, **ang Liu, **aorong Peng… in Journal of Neuroinflammation (2023)

Article

Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway

Postoperative pain is a serious clinical problem with a poorly understood mechanism, and lacks effective treatment. Hydrogen (H₂) can reduce neuroinflammation; therefore, we hypothesize that H₂ may alleviate post...

Juan Li, Shirong Ruan, **hui Jia, Qian Li, Rumeng Jia… in Journal of Neuroinflammation (2023)

Article

TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation

The impairment in the autophagy-lysosomal pathway (ALP) and the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration and neuroinfl...

Wenjia Lin, Zhao Li, Guangfeng Liang, Run** Zhou… in Journal of Neuroinflammation (2023)

Article

Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis

Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs), which play a pivotal role in inducing either inflammatory or tolerogenic response based on their subtypes and environment...

Caiyun Liu, Jie Zhu, Yan Mi, Tao ** in Journal of Neuroinflammation (2022)

Article

Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury

Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which functions to reduce fat production, inhibit inflammation, and reduce serum cholesterol levels. The role of PPA in the con...

**angyi Kong, Wenjie Hu, Yu Cui, **gchen Gao, Xu** Yao… in Molecular Neurobiology (2022)

Article

AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia–Ischemia Injury

There are sex differences in the severity, mechanisms, and outcomes of neonatal hypoxia–ischemia (HI) brain injury, and apoptosis-inducing factor (AIF) may play a critical role in this discrepancy. Based on pr...

Tao Li, Yanyan Sun, Shan Zhang, Yiran Xu, Kenan Li, Cuicui **e… in Molecular Neurobiology (2022)

Article

Cadmium Through Disturbing MTF1-Mediated Metal Response Induced Cerebellar Injury

Cadmium (Cd) is a toxic environmental contaminant, which bio-accumulate in animals through the food chain. Cerebellum is one of the primary target organs for Cd exposure. In this study, we established a chroni...

Shao-Shuai Bi, Milton Talukder, Hai-Tao **, Mei-Wei Lv, **g Ge… in Neurotoxicity Research (2022)

Article

Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model

Mesenchymal stem cell (MSCs)-derived small Extracellular Vesicles (sEVs) are considered as a new cell-free therapy for pain caused by nerve injury, but whether human placental mesenchymal stem cell-derived sEV...

Yitian Lu, **tao Zhang, Fanning Zeng, Peng Wang… in Journal of Neuroinflammation (2022)

Article

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

Triggering receptor expressed on myeloid cell 1 (Trem1) is an important regulator of cellular inflammatory responses. Neuroinflammation is a common thread across various neurological diseases. Soluble Trem1 (s...

**aolei Shi, Tao Wei, Yachun Hu, Meng Wang, Yi Tang in Journal of Neuroinflammation (2022)

Article

Transcriptome profiling of microRNAs reveals potential mechanisms of manual therapy alleviating neuropathic pain through microRNA-547-3p-mediated Map4k4/NF-κb signaling pathway

Local neuroinflammation secondary to spinal nerve compression in lumbar disk herniation (LDH) is a key driver contributing to neuropathic pain. Manual therapy (MT), a widely used nonsurgical therapy, can relie...

Chongjie Yao, Jun Ren, Ruixin Huang, Cheng Tang… in Journal of Neuroinflammation (2022)

Article

Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases. Herein,...

Peng **, Dongqing Qi, Yuhui Cui, Cameron Lenahan… in Journal of Neuroinflammation (2022)

Article

Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis

Traumatic brain injury (TBI) provokes secondary pathological damage, such as damage to the blood–brain barrier (BBB), ischaemia and inflammation. Major facilitator superfamily domain-containing 2a (Mfsd2a) has...

Yuan Zhang, Lin Wang, Qiuling Pan, **aomin Yang… in Fluids and Barriers of the CNS (2022)