1,262 Result(s)
within
Neurosciences
**u Tao
Article
Biomedicine
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Article
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up...
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Differential regulation of synaptic and extra-synaptic NMDA receptors
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown—the decline of peak current with repeated, sustained agonist application1,2,3,
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Defective NF-κB activation in virus-infected neuronal cells is restored by genetic complementation
The interferon-beta (IFNβ) gene is not inducible in neuronal cells in response to measles virus (MV) due to lack of nuclear factor kappa B (NF-κB) activation. NF-κB is normally sequestered in the cytoplasm by an ...
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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Ras acts with other proteins to induce neoplasia. By itself, however, strong Ras signaling can suppress proliferation of normal cells. In primary epidermal cells, we found that oncogenic Ras transiently decrea...
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Deletion of cytosolic phospholipase A2 promotes striated muscle growth
Generation of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular homeostasis, inflammation and tumorigenesis. Here we report that...
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Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
Dengue virus presents a growing threat to public health in the develo** world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (...
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Erratum: Deletion of cytosolic phospholipase A2 promotes striated muscle growth
Nat. Med. 9, 944–951 (2003) In the version of this article initially published online, the last sentence of the 'Isolation of Plag4a−/− and wild-type glomerular mesangial cells' section of the Methods containe...
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Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens
Morphine is one of the most effective analgesics in clinic to treat postoperative pain or cancer pain. A major drawback of its continuous use is the development of tolerance and dependence. In our previous stu...
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A novel model of motor learning capable of develo** an optimal movement control law online from scratch
A computational model of a learning system (LS) is described that acquires knowledge and skill necessary for optimal control of a multisegmental limb dynamics (controlled object or CO), starting from “knowing”...
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Effects of morphine and endomorphins on the polysynaptic reflex in the isolated rat spinal cord
At the spinal level, μ-opioids exert their actions on nociceptive primary afferent neurons both pre- and postsynaptically. In the present study, we used an in vitro isolated neonatal rat (11–15 days old) spina...
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Pharmacological study of the novel compound FLZ against experimental parkinson’s models and its active mechanism
FLZ is a synthetic new derivative of squamosamide. Pharmacological study found that FLZ given orally improved the abnormal behavior caused by the functional disturbance of dopaminergic and cholinergic neurons ...
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bHLH genes and retinal cell fate specification
The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body ...
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Determining natural arm configuration along a reaching trajectory
Owing to the flexibility and redundancy of neuromuscular and skeletal systems, humans can trace the same hand trajectory in space with various arm configurations. However, the joint trajectories of typical unr...
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Identification of Up-Regulated Genes After Complete Spinal Cord Transection in Adult Rats
Spinal cord injury (SCI) initiates a cascade of events and these responses to injury are likely to be mediated and reflected by changes in mRNA concentrations. As a step towards understanding the complex mecha...
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Soluble endoglin contributes to the pathogenesis of preeclampsia
Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by excess placenta-derived soluble VEGF ...
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Molecular approaches to brain asymmetry and handedness
The left and right hemispheres of the human brain have distinct functions: for example, the left is normally dominant for language and logical processing, wher...
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The virtue of simplicity
Multiple local motions must be combined to determine the direction of object motion, which is harder than it seems. A new paper proposes an elegant and simple solution to this problem, eminently realizable in ...
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Developmental change of α-gustducin expression in the mouse fungiform papilla
Developmental changes in the distribution pattern of taste buds in newborn mouse have not been previously elucidated, and little work has been done to examine the postnatal alteration of the expression of α-gu...
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Increased protein and mRNA expression of endostatin in the ischemic brain tissue of rabbits after middle cerebral artery occlusion
To explore the changes of endostatin (a strong anti-angiogenesis factor) and vascular endothelial growth factor (VEGF) in the brain tissues of rabbits following cerebral ischemia induced by middle cerebral art...
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Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity
In the adult heart, a variety of stresses induce re-expression of a fetal gene program in association with myocyte hypertrophy and heart failure. Here we show that histone deacetylase-2 (Hdac2) regulates expre...
