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  1. No Access

    Article

    Placental Pathology Casebook: Serpentine Aneurysms of the Placenta with Fetal Consequences

    Two cases of placental surface vessel aneurysms are presented. One case was associated with severe fetal intrauterine growth restriction and fetal thrombocytopenia. The other case was associated with “molar tr...

    Kurt Benirschke MD, Peilin Zhang MD, Kurt Benirschke MD in Journal of Perinatology (2000)

  2. Article

    Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

    To understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (TRD), we studied the effects of olanzapine and other antipsychotics in ...

    Wei Zhang MD, Ph.D, Kenneth W Perry MS, David T Wong Ph.D… in Neuropsychopharmacology (2000)

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  3. No Access

    Article

    Comparison of corneal endothelial changes after use of different adjuncts during lens implantation

    To evaluate postoperative changes in corneal endothelial cell density, we conducted a retrospective study in 34 patients (35 eyes). Patients underwent extracapsular cataract extraction and posterior chamber le...

    Hua Yan MD, Qi Han MD, Fu Kun Zhang MD, Gui Qin Jia MD… in Annals of Ophthalmology (2000)

  4. Article

    Open Access

    Autoimmune Hypogonadism as Part of an Autoimmune Polyglandular Syndrome

    The most compelling case for autoimmune mediated hypogonadism occurs when ovarian failure is part of an autoimmune polyglandular syndrome (APS). In patients with the rare, recessively inherited type 1 APS (APS...

    Noel Maclaren MD, Qiao-Yi Chen PhD… in The Journal of the Society for Gynecologic… (2001)

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  5. No Access

    Article

    Ramification Amplification: A Novel Isothermal DNA Amplification Method

    We have developed a novel isothermal DNA amplification method with an amplification mechanism quite different from conventional PCR. This method uses a specially designed circular probe (C-probe) in which the ...

    David Y. Zhang MD, PhD, Margaret Brandwein MD, Terence Hsuih MD… in Molecular Diagnosis (2001)

  6. No Access

    Article

    Nifedipine Block of Capacitative Calcium Entry in Cultured Human Uterine Smooth-Muscle Cells

    To determine whether nifedipine inhibits capacitative calcium entry at clinically relevant concentrations using cultured human myocytes as a model for human myometrium.

    Roger C. Young MD, PhD, Ralph Schumann BA… in The Journal of the Society for Gynecologic… (2001)

  7. No Access

    Article

    Radiofrequency Ablation for Eradication of Renal Tumor in a Rabbit Model by Using a Cooled-tip Electrode Technique

    Background:Radiofrequency ablation (RFA) has emerged as a potential alternative for surgery in clinical oncology. This animal experiment was conducted to evaluate the feasibility of RFA i...

    Yi Miao MD, PhD, Yicheng Ni MD, PhD, Hilde Bosmans PhD… in Annals of Surgical Oncology (2001)

  8. Article

    Role of Dopamine D4 Receptors in Motor Hyperactivity Induced by Neonatal 6-Hydroxydopamine Lesions in Rats

    The role of dopamine D4 receptors in behavioral hyperactivity was investigated by assessing D4 receptor expression in brain regions and behavioral effects of D4 receptor-selective ligands in juvenile rats with ne...

    Kehong Zhang MD, Ph.D, Frank I Tarazi Ph.D… in Neuropsychopharmacology (2001)

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  9. No Access

    Article

    Differential Detection of Cytomegalovirus Immediate-early Messenger RNA in Clinical Samples Using Ligation-dependent PCR

    Background: Cytomegalovirus (CMV) causes life-threatening infections in immunocompromised patients, especially those with acquired immunodeficiency or organ transplants. Therefore, early detectio...

    Fann Wu PhD, Hongbo Li BS, David Y. Zhang MD, PhD in Molecular Diagnosis (2001)

  10. Article

    Stem Cells in Neurodevelopment and Plasticity

    The processes of stem cell proliferation and differentiation during embryogenesis are governed by transcription factors that regulate the regional differentiation of the central nervous system (CNS). Do neural...

    Flora M Vaccarino MD, Yosif Ganat, Yuchun Zhang MD, Wei Zheng MD in Neuropsychopharmacology (2001)

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  11. No Access

    Article

    Animal models for scleroderma: An update

    Scleroderma is a progressive debilitating fibrosing disease that may involve multiple organs. The pathogenesis of this disease remains unclear. Animal models for scleroderma are valuable for studying the patho...

    Yan Zhang MD, Anita C. Gilliam MD, PhD in Current Rheumatology Reports (2002)

  12. No Access

    Article

    Anti-Tumor Efficacy of a Novel Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in Human Colon Cancer Models: p53-Dependent and p53-Independent Mechanisms

    The MDM2 oncogene is amplified or overexpressed in many human cancers and MDM2 levels are associated with poor prognosis. MDM2 not only serves as a negative regulator of p53 but also has p53-independent activi...

    Hui Wang, Li Nan, Dong Yu, J. Russell Lindsey, Sudhir Agrawal… in Molecular Medicine (2002)

  13. Article

    Plasticity of Dopamine D4 Receptors in Rat Forebrain: Temporal Association with Motor Hyperactivity Following Neonatal 6-Hydroxydopamine Lesioning

    Genetic studies suggest that dopamine D4 receptor polymorphism is associated with attention deficit hyperactivity disorder (ADHD). We recently reported that motor hyperactivity in juvenile male rats with neonatal...

    Kehong Zhang MD, Ph.D, Frank I Tarazi Ph.D, Eugen Davids MD… in Neuropsychopharmacology (2002)

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  14. No Access

    Article

    Sympathetic nervous system function in renal hypertension

    Hypertension is a common complication of chronic renal failure, accelerating the deterioration in renal function and constituting an important risk factor for the excessive cardiovascular morbidity and mortali...

    Meryem Tuncel MD, Robert Augustyniak PhD… in Current Hypertension Reports (2002)

  15. Article

    Antidepressant-like Profile and Reduced Sensitivity to Rolipram in Mice Deficient in the PDE4D Phosphodiesterase Enzyme

    Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) produces antidepressant-like effects in animals; however, it is not known which of the four PDE4 sub...

    Han-Ting Zhang MD, Ph.D, Ying Huang MD, S-L Catherine ** Ph.D… in Neuropsychopharmacology (2002)

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  16. No Access

    Article

    Animal models of ankylosing spondylitis

    The pathology of ankylosing spondylitis (AS) and related spondyloarthropathies (SpA) characteristically involve a sacroiliitis and inflammation of the intervertebral discs (IVD) in the lumbar spine, and an ent...

    Yi** Zhang MD, PhD, Shuilang Shi PhD… in Current Rheumatology Reports (2002)

  17. No Access

    Article

    Antioxidant Superoxide Dismutase Attenuates Increased Endothelial Permeability Induced By Platelet-Activating Factor

    TO study the protective effects of the antioxidant superoxide dismutase (SOD) against platelet-activating factor (PAF)-induced endothelial permeability.

    Yan** Zhang MD, Yang Gu MD… in The Journal of the Society for Gynecologic… (2003)

  18. No Access

    Article

    Psychotic disorder and traumatic brain injury

    Traumatic brain injury (TBI) can result in serious and disabling neuropsychiatric disorders, such as cognitive deficits and personality change, as well as severe and chronic psychosis. This review focuses on t...

    Qingchen Zhang MD, PhD, Perminder S. Sachdev MD, PhD, FRANZCP in Current Psychiatry Reports (2003)

  19. No Access

    Article

    Regression of left ventricular hypertrophy is a key goal of hypertension management

    Left ventricular hypertrophy (LVH) in patients with hypertension is associated with an increased risk for many cardiovascular events and predicts a higher mortality rate. The pathogenesis of LVH is complicated...

    Rubin Zhang MD, Judy Crump MD, Efrain Reisin MD in Current Hypertension Reports (2003)

  20. No Access

    Article

    Multicenter, randomized, controlled trial of heat-killedLactobacillus acidophilus LB in patients with chronic diarrhea

    Chronic diarrhea is a common bowel disorder; disturbance of intestinal microorganisms may play a role in its pathogenesis. This study assessed the clinical efficacy of lyophilized, heat-killedLactobacillus acidop...

    Shy-Dong **ao MD, Zhong De Zhang MD, Hong Lu MD, Shi Hu Jiang MD… in Advances in Therapy (2003)

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