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Article
Open AccessCharacterizing the cancer genome in lung adenocarcinoma
A wide-ranging overview of genetic alterations in lung adenocarcinomas, published in this issue, takes a new approach to genome analysis. The analysis of 371 tumours revealed 31 recurrent focal events, only si...
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Article
An illustration of the potential for map** MRI/MRS parameters with genetic over-expression profiles in human prostate cancer
Magnetic resonance imaging (MRI) and MR spectroscopy can probe a variety of physiological (e.g. blood vessel permeability) and metabolic characteristics of prostate cancer. However, little is known about the c...
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Article
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Matthew Meyerson and colleagues report that SOX2, which encodes a transcription factor necessary for normal esophageal development, is an amplified lineage survival oncogene in lung and esophageal squamous cell c...
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Article
Open AccessMolecular sampling of prostate cancer: a dilemma for predicting disease progression
Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict dise...
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Article
Open AccessExpression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural development. More recently, SOX2 was shown to participate in...
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Article
Sequential resection of malignant ureteral margins at radical cystectomy: a critical assessment of the value of frozen section analysis
The aim of this study was to evaluate the accuracy of frozen section analysis (FSA) for detecting and eliminating malignant ureteral margins at radical cystectomy (RC) and to determine the impact of final marg...
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Article
Open AccessThe HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches
The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling ...
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Article
ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer
Castration-resistant prostate cancer is the second most common cause of cancer death and results in a median survival of less than 2 years. In prostate cancer, fusions between TMPRSS2 and ERG are common. The ERG ...
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Article
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Roman Thomas and colleagues report exome sequencing of 29 small-cell lung cancers (SCLCs), 2 SCLC genomes and transcriptomes of 15 SCLCs. They identify recurrent mutations in the CREBBP, EP300 and MLL genes encod...
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Article
Landscape of chromosome number changes in prostate cancer progression
Both genetic instability resulting in aneuploidy and increased proliferative activity are common features of tumor development and progression. Cytometric evaluation of tumor ploidy status was recently suggest...
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Article
Open AccessAn international effort towards develo** standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge
There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices ...
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Article
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy n...
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Article
A new bright-field dual-colour chromogenic and silver in situ hybridization method for the detection of FGFR1 gene copy number status
Recently, the fibroblast growth factor receptor 1 (FGFR1) has been identified as the first actionable target in squamous cell lung cancer. Clinical trials testing specific FGFR inhibitors are in progress, and ...
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Article
Prognostic significance of phospho-histone H3 in prostate carcinoma
Prostate cancer is the second most common cancer in men and the sixth most common cause of death from cancer in men worldwide. Currently, a sufficient pathological distinction between patients requiring furthe...
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Article
Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer
Activation of the insulin-like growth factor 1 receptor may underlie clinical resistance to inhibition of the anaplastic lymphoma receptor kinase in lung cancer.
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Article
Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis
The authors delineate a new pathway that regulates apoptosis, involving the known proapoptotic kinase PKCD, as well as the ubiquitin ligase Fbox protein FBXO25 and the mitochondrial antiapoptotic factor HAX-1,...
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Article
Open AccessIdentification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Genomic translocation events frequently underlie cancer development through generation of gene fusions with oncogenic properties. Identification of such fusion transcripts by transcriptome sequencing might hel...
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Article
Open AccessIdentification of novel long non-coding RNAs in clear cell renal cell carcinoma
Long non-coding RNAs (lncRNA) play an important role in carcinogenesis; knowledge on lncRNA expression in renal cell carcinoma is rudimental. As a basis for biomarker development, we aimed to explore the lncRN...
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Article
Staurosporine analogs promote distinct patterns of process outgrowth and polyploidy in small cell lung carcinoma cells
We have recently shown that staurosporine mediates the conversion of small cell lung carcinoma (SCLC) cells into a neuron-like process-bearing phenotype. Here, we have extended these studies to the staurospori...
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Article
Open AccessSTAT3 regulated ARF expression suppresses prostate cancer metastasis
Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benef...
