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  1. No Access

    Article

    Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor–Ig fusion decoy

    Islet transplantation is a viable long-term therapeutic alternative to daily insulin replacement for type I diabetes. The allogeneic nature of the transplants poses immunological challenges for routine clinica...

    J Machen, S Bertera, Y Chang, R Bottino, AN Balamurugan, PD Robbins… in Gene Therapy (2004)

  2. No Access

    Article

    Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis

    The current study evaluated the protective effects of anti-inflammatory cytokine gene transfer on osteolysis provoked by orthopedic biomaterial particles using a murine model of inflammatory bone loss. A secti...

    S-Y Yang, B Wu, L Mayton, P Mukherjee, PD Robbins, CH Evans, PH Wooley in Gene Therapy (2004)

  3. No Access

    Article

    Osteoarthritis gene therapy

    Osteoarthritis (OA) is the Western world's leading cause of disability. It is incurable, costly and responds poorly to treatment. This review discusses strategies for treating OA by gene therapy. As OA affects...

    CH Evans, JN Gouze, E Gouze, PD Robbins, SC Ghivizzani in Gene Therapy (2004)

  4. No Access

    Article

    Gene therapy approaches for osteogenesis imperfecta

    Osteogenesis imperfecta (OI) is a heterogeneous group of genetic disorders that affect connective tissue integrity. The hallmark of OI is bone fragility, although other manifestations, which include osteoporos...

    C Niyibizi, S Wang, Z Mi, PD Robbins in Gene Therapy (2004)

  5. No Access

    Article

    Gene delivery to cartilage defects using coagulated bone marrow aspirate

    The long-term goal of the present study is to develop a clinically applicable approach to enhance natural repair mechanisms within cartilage lesions by targeting bone marrow-derived cells for genetic modificat...

    A Pascher, GD Palmer, A Steinert, T Oligino, E Gouze, J-N Gouze, O Betz… in Gene Therapy (2004)

  6. Article

    Efficacy of retroviral gene transfer into synovial fibroblasts is reduced by co-transduction with adenoviral vectors

    U Müller-Ladner, O Distler, S Gay, E Neumann, M Judex… in Arthritis Research & Therapy (2002)

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  7. No Access

    Article

    Redirecting adenovirus to pulmonary endothelium by cationic liposomes

    Somatic gene transfer to the pulmonary endothelium may be a useful strategy for modifying the phenotype of endothelium and/or vascular smooth muscle in disorders such as primary pulmonary hypertension, ARDS or...

    Z Ma, Z Mi, A Wilson, S Alber, PD Robbins, S Watkins, B Pitt, S Li in Gene Therapy (2002)

  8. No Access

    Article

    Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

    Osteoarthritis in horses and in humans is a significant social and economic problem and continued research and improvements in therapy are needed. Because horses have naturally occurring osteoarthritis, which ...

    DD Frisbie, SC Ghivizzani, PD Robbins, CH Evans, CW McIlwraith in Gene Therapy (2002)

  9. No Access

    Article

    Gene therapy for osteoporosis: evaluation in a murine ovariectomy model

    Various cytokines and cytokine antagonists hold promise as new therapeutic agents for osteoporosis, but their application is hindered by delivery problems. Gene transfer offers an attractive technology with wh...

    AWA Baltzer, JD Whalen, P Wooley, C Latterman, LM Truchan, PD Robbins… in Gene Therapy (2001)

  10. Article

    Viral, nonviral and peptide-mediated intra-articular transfer of genes and proteins

    PD Robbins, Z Mi, X Lu, J Mai, SC Ghivizanni, CH Evans… in Arthritis Research & Therapy (2001)

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  11. Article

    Transfer and intra-articular expression of the IL-1Ra cDNA in human rheumatoid joints

    CH Evans, PD Robbins, SC Ghivizzani, JH Herndon, MC Wasko… in Arthritis Research & Therapy (2001)

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  12. Article

    Update on the contralateral effect in rabbit and mouse models

    PD Robbins, ER Lechman, S-H Kim, A Gambotto, J Whalen… in Arthritis Research & Therapy (2001)

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  13. Article

    Induction of synovial apoptosis by gene transfer and peptide mediated protein transduction

    TJ Oligino, Q Yao, S Wang, JC Glorioso, CH Evans… in Arthritis Research & Therapy (2001)

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  14. Article

    Gene therapy for cartilage healing

    SC Ghivizzani, TJ Oligino, E Gouze-Decaris, G Palmer… in Arthritis Research & Therapy (2001)

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  15. Article

    Double and triple gene transfer in arthritis

    U Müller-Ladner, E Neumann, M Fleck, T Pap, RE Gay… in Arthritis Research & Therapy (2001)

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  16. No Access

    Article

    Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: identification of an H2-Kd-restricted CTL epitope

    Enhanced green fluorescent protein (EGFP) is a novel marker gene product, which is readily detectable using techniques of fluorescence microscopy, flow cytometry, or macroscopic imaging. In the present studies...

    A Gambotto, G Dworacki, V Cicinnati, T Kenniston, J Steitz, T Tüting… in Gene Therapy (2000)

  17. No Access

    Article

    Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro

    Dendritic cells (DC) are highly specialised, bone marrow (BM)-derived antigen-presenting cells (APC) that initiate and regulate immune responses. They provide costimulatory signals (in particular, CD40 and the...

    T Takayama, AE Morelli, PD Robbins, H Tahara, AW Thomson in Gene Therapy (2000)

  18. No Access

    Article

    The selectable marker neo gene down-regulates gene expression from retroviral vectors containing an internal ribosome entry site

    The internal ribosome entry site (IRES) from the picornavirus family has frequently been used to express multiple genes from a polycistronic message in retroviral vectors. While examining factors affecting lev...

    J Byun, J-M Kim, PD Robbins, S Kim in Gene Therapy (1998)

  19. No Access

    Article

    Interferon-α gene therapy for cancer: retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models

    Stable transfection of tumor cells with IFN-α genes has been shown to result in abrogation of tumor establishment and induction of antitumor immunity. However, strategies suitable for the clinical application ...

    T Tüting, A Gambotto, J Baar, ID Davis, WJ Storkus, PJ Zavodny, S Narula… in Gene Therapy (1997)

  20. No Access

    Article

    Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy

    We have investigated the feasibility of using high-titer murine leukemia virus-based retroviral vectors to deliver exogenous genes to naive and chronically inflamed knee joints of rabbits in vivo. Intraarticul...

    SC Ghivizzani, ER Lechman, C Tio, KM Mulé, S Chada, JE McCormack, CH Evans… in Gene Therapy (1997)

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