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Article
Therapy of complicated Crohn’s disease during pregnancy—an interdisciplinary challenge
Severe courses of Crohn’s disease (CD) during pregnancy are rare. However, if occurring, the risk of miscarriage and low birth weight is increased. At present, only limited data is available on the treatment o...
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Article
Therapierefraktäre chronisch entzündliche Darmerkrankungen
Operieren unter Immunsuppression ist ein hochaktuelles Thema in der Chirurgie chronisch entzündlicher Darmerkrankungen. Durch den Wandel der Therapieregime kommt kaum noch ein Patient ohne Immunsuppression zur...
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Article
Akute Sigmadivertikulitis
Die Sigmaresektion gilt heute als Standardverfahren bei der komplizierten und rezidivierenden Sigmadivertikulitis (SD). Im letzten Jahrzehnt hat sich ein deutlicher Wandel in der präoperativen Diagnostik (CT) ...
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Article
Abdominal Resection Rectopexy with an Absorbable Polyglactin Mesh: Prospective Evaluation of Morphological and Functional Changes with Consecutive Improvement of Patient’s Symptoms
The pathophysiology of rectal prolapse and intussusception has not yet been clarified. This is reflected in the multiplicity of surgical procedures. The aim of this prospective study was to measure morphologic...
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Chapter and Conference Paper
Metaplastische Paneth Zellen bei chronisch-entzündlichen Darmerkrankungen
The pathogenesis of the inflammatory bowel disease comes out to be complex and multifactor event. Pathological changes seem to occur already in gene pool. The existent term of IBD genetics suggest several know...
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Article
Staging Anal Cancer: Prospective Comparison of Transanal Endoscopic Ultrasound and Magnetic Resonance Imaging
The staging of anal cancer is extremely important for therapy and prognosis. Transanal endoscopic ultrasound and magnetic resonance imaging are routinely applied. The aim of this prospective comparative study ...
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Chapter and Conference Paper
Enhanced activity of immunoproteasomes in patiens with Crohn’s disease
The eukaryotic 20S proteasome is the main protease in the cytoplasm and nucleus composed of seven different α and seven different β subunits which form four rings stacked on top of each other. It is now known ...
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Chapter and Conference Paper
Detection and quantification of defensin positive cells in the ileac submucosal layer of patients with Crohn’s disease under medical treatment
Background & Aims: Defensins are peptides with antimicrobial function which play a pivotal role for the maintenance of the intestinal barrier function. They are known as effectors of neutrophils,...
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Article
Occurrence of adenomas in the pouch and small intestine of FAP patients after proctocolectomy with ileoanal pouch construction
Proctocolectomy with ileoanal pouch construction is the standard therapy for patients with familial adenomatous polyposis coli (FAP) to prevent the genesis of colorectal carcinomas. In our patient population, ...
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Chapter and Conference Paper
Einfluss proinflammatorischer Zytokine auf die Expression von humanem ß2-Defensin in Darmepithelien — In-vitro-Untersuchungen im Modell mit der epithelialen Zelllinie HT-29
In Crohn’s disease an altered intestine mucosal barrier and cellular cytokine-mediated immune responses against commensal flora was described before. Taking part in the barrier function, human β2-defensin (HBD...
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Article
Kontinente Stuhlreservoire – eine chirurgische Herausforderung
Durch Optimierung der operativen Techniken werden heutzutage Patienten mit einem tief sitzenden Rektumkarzinom durch eine tiefe anteriore Rektumresektion mit koloanaler Anastomose unter Vermeidung eines perman...
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Chapter and Conference Paper
Etablierung eines Nachweises direkter antibakterieller Wirkung humaner Defensine für die Untersuchung der Defensinproduktion im menschlichen Darm bei Patienten mit Morbus Crohn und Colitis Ulcerosa
As a part of the innate immunity, defensins support the preservation of the intestinal mucosal barrier which is affected in IBD patients. It is interesting whether a potential direct antibacterial activity of ...
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Article
Manometric study in ulcerative colitis patients with modified ileal pouch-anal anastomosis by G. Kobakov et al.
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Chapter and Conference Paper
Bakterielle Permeation bei Patienten mit chronisch entzündlichen Darmerkrankungen (CED)
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Chapter
Chronisch entzündliche Darmerkrankungen
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Article
Simplified placement and management of cutting setons in the treatment of transsphincteric anal fistula
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Chapter and Conference Paper
Der Einfluss des von Bacteroides fragilis gebildeten Toxins BFT auf die gesunde Darmschleimhaut
Enterotoxigenic strains of Bacteroides fragilis produce a 20-kDa metalloprotease toxin (BFT) which is associated with diarrheal disease in animals, children and adults. Experimental studies have suggested that th...
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Chapter
Operationsindikation und Strategie beim stumpfen und penetrierenden Trauma
Das Thoraxtrauma ist eine der wichtigsten Teilverletzungen des polytraumatisierten Patienten.
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Chapter and Conference Paper
Möglichkeit der Pouchitis-Therapie durch Interleukin-10 im ileoanalen Pouch nach Colitis ulcerosa?
Die Pouchitis nach ileoanaler Pouchanlage weist neben der immunologischen Reaktion viele Analogien zur Colitis ulcerosa auf. Hinsichtlich der Zytokin-Expression ist bekannt, dass während der Pouchitis die proi...
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Chapter and Conference Paper
Rolle der bakteriellen Permeation in ileoanalen Pouches
Bacterial overgrowth seems to play an important role in the pathogenesis of ileoanal pouches. Hence the capability of bacterial permeation and their determinants is of great interest. The aim of this study was...
