58 Result(s)
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Chapter
Gene therapy for management of lupus: Correction of Fas and Fas ligand-induced apoptosis in murine disease — therapeutic rationale and strategies
Identification of mutations of fas and fas ligand (fasL) in murine models of autoimmune disease have provided an important experimental tools for the analysis of tolerance and autoimmune disease. Mutations of fas...
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Chapter
Apoptosis
Apoptosis is a physiologic process that mediates the death of selected cells. In contrast to necrosis, which results from a strong nonspecific or toxic cell injury, apoptosis is initiated by ligand—receptor in...
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Article
Apoptosis and rheumatoid arthritis: Past, present, and future directions
The current studies of apoptosis in rheumatoid arthritis (RA) suggest that molecules (Fas-related or TNF-related), pathways (activation of pro-apoptosis or anti-apoptosis pathway), cell types (lymphocytes or s...
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Article
Regulation of apoptosis proteins in cancer cells by ubiquitin
Ubiquitin inhibitors act at many levels to enhance apoptosis signaling. For TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling, there are at least five mechanisms by which apoptosis are...
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Article
Phytoestrogen-rich herb formula “XLGB” prevents OVX-induced deterioration of musculoskeletal tissues at the hip in old rats
This study investigated a phytoestrogen-rich herb formula, **anlinggubao (XLGB) μncluding genistein 510μg/g and daidzein 2500μg/g), concerning prevention of OVX-induced deterioration of musculoskeletal tissues...
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Chapter
Multiple Bio-imaging Modalities in Evaluation of Epimedium-Derived Phytoestrogenic Fraction for Prevention of Postmenopausal Osteoporosis
Recently, we extracted phytoestrogenic fraction (PF) from herbal Epimedium, which is a kind of traditional Chinese medicine (TCM) known as a “bone-strengthening Chinese herb.” This herb has been widely prescri...
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Chapter
Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis
We developed an alternative steroid-associated osteonecrosis (ON) rabbit model using a combination of a single injection of low-dose lipopolysaccharide (LPS) and three subsequent injections of pulsed high-dose...
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Article
Open AccessElevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development
Increased bone marrow lipid deposition in steroid-associated osteonecrosis (ON) implies that abnormalities in fat metabolism play an important role in ON development. The increase in lipid deposition might be ...
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Article
Effect of epimedium-derived phytoestrogen on bone turnover and bone microarchitecture in OVX-induced osteoporotic rats
To investigate the preventive effect of epimedium-derived phytoestrogen (PE) on osteoporosis induced by ovariectomy (OVX) in rats, 11-month-old female Wistar rats were randomly divided into Sham, OVX and PE gr...
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Article
Low-dose X-irradiation promotes mineralization of fracture callus in a rat model
This study investigated the hypothesized beneficial effect of low-dose irradiation (LDI) on fracture callus mineralization in a rat model.
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Article
The utility of angiographic CT in the diagnosis and treatment of neurovascular pathologies in the vicinity of cranial base
This study aims to explore the utility of angiographic computed tomography (CT) in the diagnosis and treatment of neurovascular pathologies in the vicinity of cranial base. Two cases of cranial base dural arte...
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Article
Open AccessAttenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
This study was performed to evaluate the attenuation of osteoarthritic (OA) pathogenesis via disruption of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) signaling with AMD31...
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Article
Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer MR Imaging at 3-Tesla and Its Application to High-Grade Human Brain Tumors
Amide proton transfer (APT) imaging is able to extend the achievable magnetic resonance imaging (MRI) contrast to the protein level. In this study, we demonstrate the feasibility of applying a turbo-spin-echo ...
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Article
Erratum to: Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
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Article
Open AccessErythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditions
Erythropoietin (EPO) provides an alternative to transfusion for increasing red blood cell mass and treating anemia in cancer patients. However, recent studies have reported increased adverse events and/or redu...
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Article
Expression of thymidylate synthase predicts clinical outcomes of pemetrexed-containing chemotherapy for non-small-cell lung cancer: a systemic review and meta-analysis
Observational and preclinical studies suggested an association between the expression of thymidylate synthase (TS) and clinical effects of pemetrexed-based chemotherapy in non-small-cell lung cancer (NSCLC) pa...
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Article
Open AccessDisrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreER T2 ; Ihhfl/fl mice
Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, ther...
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Article
Open AccessExosomes: an overview of biogenesis, composition and role in ovarian cancer
Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such a...
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Article
Open AccessFei-Liu-** ointment inhibits lung cancer growth and invasion by suppressing tumor inflammatory microenvironment
Lung cancer is one of the leading causes of cancer-related mortality worldwide. Conventional chemotherapy and radiotherapy are the primary therapeutic methods for lung cancer with the use of combination therap...
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Article
Progress and perspectives of biomarker discovery in Chinese medicine research
Biomarker discovery in Chinese medicine (CM) has recently attracted a great deal of attention, owing to the promise of high-throughput technologies development and the potential of Chinese herbal medicine. Fur...
