Synonyms
Definition
d-Cycloserine, a structural analog of d-alanine, is a broad-spectrum antibiotic produced by certain strains of Streptomyces orchidaceus or S. garphalus. d-Cycloserine is an FDA-approved medication classified as second-line drug for the treatment of tuberculosis already in human use since the 1950s. A few decades later, it was found that following penetration into the central nervous system (CNS), d-cycloserine has modulatory properties at the N-methyl-d-aspartate glutamate receptor (NMDAR) (Hood et al. 1989). Since NMDARs play a critical role in neuroplasticity, learning, and memory, current research focuses on the mechanisms of action and therapeutic potential of d-cycloserine in neuropsychiatric disorders including schizophrenia, cognitive dysfunctions, and affective and anxiety disorders.
Pharmacological Properties
Mechanisms of Action
d-Cycloserine may be bactericidal or bacteriostatic, depending...
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References
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Durrant, A.R., Heresco-Levy, U. (2014). d-Cycloserine. In: Stolerman, I., Price, L. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27772-6_7018-2
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DOI: https://doi.org/10.1007/978-3-642-27772-6_7018-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27772-6
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Chapter history
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Latest
-Cycloserine- Published:
- 19 September 2014
DOI: https://doi.org/10.1007/978-3-642-27772-6_7018-2
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Original
-Cycloserine- Published:
- 17 April 2014
DOI: https://doi.org/10.1007/978-3-642-27772-6_7018-1