Synonyms
Catecholamine depletion; Monoamine depletion; Tryptophan depletion
Definition
Amine depletion refers to a pharmacological or dietary manipulation that lowers levels of monoamine neurotransmitters in the brain for therapeutic or investigational purposes. An amine depletor is therefore an agent that diminishes levels of one or more monoamines in the brain.
Pharmacological Properties
Available Methodologies
The monoamines targeted by amine depletion are typically the catecholamine neurotransmitters, dopamine and noradrenaline, and the indoleamine neurotransmitter, serotonin. Amine depletion in humans can be carried out in three principal ways:
- 1.
Through pharmacological inhibition of vesicular storage of amines in the nerve terminal
- 2.
Through pharmacological inhibition of neurotransmitter synthesis
- 3.
Through dietary-induced brain depletion of amino acids required for neurotransmitter synthesis
Monoamine depletion may also occur as an adverse consequence of drug use, both licit...
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References
Booij L, Van der Does AJW, Benkelfat C, Bremner JD, Cowen PJ, Fava M, Gillin C, Leyton M, Moore P, Smith KA, Van der Kloot A (2002) Predictors of mood response to acute tryptophan depletion: a reanalysis. Neuropsychopharmacology 27:852–861
Booij L, Van Der Does AJW, Riedel WJ (2003) Monoamine depletion in psychiatric and healthy populations: a review. Mol Psychiatry 8:951–973
Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, den Ouden H, Apergis-Schoute A, Campbell-Meiklejohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012) Converging evidence for central 5-HT effects in acute tryptophan depletion. Mol Psychiatry 17:121–123
Hayward G, Goodwin GM, Cowen PJ, Harmer CJ (2005) Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms. Biol Psychiatry 57:517–524
McTavish SFB, McPherson HM, Harmer CJ, Clark L, Sharp T, Goodwin GM, Cowen PJ (2001) Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness. Br J Psychiatry 179:356–360
Ruhé HG, Mason NS, Schene AH (2007) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry 12:331–359
Smith KA, Fairburn CG, Cowen PJ (1997) Relapse of depression after rapid depletion of tryptophan. Lancet 349:915–919
van Donkelaar EL, Blokland A, Ferrington L, Kelly PAT, Steinbusch HWM, Prikaerts J (2011) Mechanism of acute tryptophan depletion: is it only serotonin? Mol Psychiatry 16:695–713
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© 2014 Springer-Verlag Berlin Heidelberg
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Cowen, P.J. (2014). Amine Depletors. In: Stolerman, I., Price, L. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27772-6_312-5
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DOI: https://doi.org/10.1007/978-3-642-27772-6_312-5
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Publisher Name: Springer, Berlin, Heidelberg
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Chapter history
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Latest
Amine Depletors- Published:
- 06 June 2014
DOI: https://doi.org/10.1007/978-3-642-27772-6_312-5
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Original
Amine Depletors- Published:
- 17 April 2014
DOI: https://doi.org/10.1007/978-3-642-27772-6_312-4