Abstract
Cell adhesion molecules (CAMs) such as intercellular adhesion molecule (ICAM-1), vascular adhesion molecule (VCAM-1), and lymphocyte function-associated antigen (LFA-1) facilitate interaction among cells of various lineages and are therefore crucial in the complex processes of inflammation and tumor growth (1,2). This chapter discusses the mechanisms of action of CAMs and offers methodologic information for their detection and identification in fresh-frozen lung tissue. In particular, this chapter describes our experience with these CAM ’s in pulmonary non-small cell carcinoma and also in non-neoplastic tissue compartments of the lung such as endothelial cells, lymphocytes, fibroblasts, alveolar epithelial cells, and bronchial epithelial cells.
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© 2003 Humana Press Inc., Totowa, NJ
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Fraire, A.E., Woda, B.A., Savas, L., Jiang, Z. (2003). Intercellular Adhesion Molecules (ICAM-1, VCAM-1, and LFA-1) in Adenocarcinoma of Lung. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicine™, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-323-2:243
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DOI: https://doi.org/10.1385/1-59259-323-2:243
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-985-8
Online ISBN: 978-1-59259-323-1
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