From genome integrity to cancer: mechanisms and translational opportunities

In this topical collection (14 articles)

1. Comment

   Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

   Paola Francica, Sven Rottenberg Article:101

   Download PDF (281KB) View Article

2. Review

   Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine

   Jake R. Conway, Eric Kofman, Shirley S. Mo, Haitham Elmarakeby… Article:93

   Download PDF (929KB) View Article

3. Research

   Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations

   Elen Kristine Höglander, Silje Nord, David C. Wedge… Article:92

   Download PDF (2767KB) View Article

4. Research

   A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

   Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid… Article:90

   Download PDF (4870KB) View Article

5. Comment

   The ins and outs of telomere crisis in cancer

   Patrick von Morgen, John Maciejowski Article:89

   Download PDF (502KB) View Article

6. Comment

   Acquired mechanisms of immune escape in cancer following immunotherapy

   J. Bryan Iorgulescu, David Braun, Giacomo Oliveira, Derin B. Keskin… Article:87

   Download PDF (1040KB) View Article

7. Research

   Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer

   Maki Tanioka, Kevin R. Mott, Daniel P. Hollern, Cheng Fan, David B. Darr… Article:86

   Download PDF (3331KB) View Article

8. Research

   Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

   Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen… Article:85

   Download PDF (1214KB) View Article

9. Research

   Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

   Vanessa L. Hale, Patricio Jeraldo, Jun Chen, Michael Mundy, Janet Yao… Article:78

   Download PDF (10531KB) View Article

10. Review

    Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response

    Elaine R. Mardis Article:71

    Download PDF (459KB) View Article

11. Review

    Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

    Jawara Allen, Cynthia L. Sears Article:11

    Download PDF (755KB) View Article

12. Research

    BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

    Raunak Shrestha, Noushin Nabavi, Yen-Yi Lin, Fan Mo, Shawn Anderson… Article:8

    Download PDF (4289KB) View Article

13. Editorial

    From genome integrity to cancer

    Serena Nik-Zainal Article:4

    Download PDF (275KB) View Article

14. Method

    Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA

    Meiling Gao, Maurizio Callari, Emma Beddowes, Stephen-John Sammut… Article:1

    Download PDF (2876KB) View Article