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Association between CLPTM1L-TERT rs401681 polymorphism and pancreatic cancer risk among Chinese Han population

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Tumor Biology

Abstract

Pancreatic cancer is one of the human cancers with the highest fatality rates; however, the etiology still remains largely unknown. Recently, one genome-wide association study (GWAS), conducted exclusively among women of European ancestry, has discovered that cleft lip and palate transmembrane 1-like telomerase reverse transcriptase (CLPTM1L-TERT) rs401681 polymorphism was significantly associated with pancreatic cancer risk. Few studies have been conducted to evaluate whether this finding could be generalized to Chinese people. In the current study, we explored the association between rs401681 polymorphism and risk of pancreatic cancer in a case–control study of 1,587 Chinese people (including 766 pancreatic cancer cases and 821 healthy controls). Under the log-additive model, each additional copy of minor allele T was associated with a 1.24-fold increased risk of pancreatic cancer (odds ratio (OR) = 1.24, 95 % confidence interval (CI) 1.06–1.44, P = 5.61 × 10−3). While compared with individuals with the CC genotype, the OR for develo** pancreatic cancer was 1.09 (95 % CI 0.88–1.34) among those with the CT genotype and 1.66 (95 % CI 1.20–2.29) among those with the TT genotype. Additional adjustments for the confounding factors did not change the results materially. Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.

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Acknowledgments

We thank all staff who were involved in the subject recruitment, telephone interviews, sample preparation, and laboratory assays for their hard works.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, 30 Fucheng Road, 100142, Bei**g, China

    Chengli Liu, Cheng Wang, Hui Zhang, Yalin Kong & Hongyi Zhang

  2. Department of Radiation Oncology, Air Force General Hospital of PLA, 100142, Bei**g, China

    Yingjie Wang

  3. Department of Hepatobiliary Surgery, 309 Hospital of PLA, 100091, Bei**g, China

    Hui Huang

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  1. Chengli Liu
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  2. Yingjie Wang
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  4. Cheng Wang
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Correspondence to Chengli Liu.

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Liu, C., Wang, Y., Huang, H. et al. Association between CLPTM1L-TERT rs401681 polymorphism and pancreatic cancer risk among Chinese Han population. Tumor Biol. 35, 5453–5457 (2014). https://doi.org/10.1007/s13277-014-1711-9

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  • DOI: https://doi.org/10.1007/s13277-014-1711-9

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