Abstract
Biomedical applications adapt Nano technology-based transistors as a key component in the biosensors for diagnosing life threatening diseases like Covid-19, Acute myocardial infarction (AMI), etc. The proposed work introduces a new biosensor, based on Graphene Field Effect Transistor (GFET), which is used in the diagnosis of Myoglobin (Mb) in human blood. Graphene-based biosensors are faster, more precise, stronger, and more trustworthy. A GFET is created in this study for the detection of myoglobin biomarker at various low concentrations. Because graphene is sensitive to a variety of biomarker materials, it can be employed as a gate material. When constructed Graphene FET is applied to myoglobin antigens, it has a significant response. The detection level for myoglobin is roughly 30 fg/ml, which is quite high. The electrical behavior of the GFET-based biosensor in detecting myoglobin marker is ideal for Lab-on-Chip platforms and Cardiac Point-of-Care Diagnosis.
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Acknowledgements
The authors are thankful to SRM University-AP, Mangalagiri-522240, Andhra Pradesh for their cooperation and support during this research work.
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B. Vamsi Krsihna, Asisa Kumar Panigrahy, V. Raja Rajeswari, and M. Durga Prakash: Conceptualization; M. Durga Prakash and B. Vamsi Krsihna: investigation; D. Mohan, Asisa Kumar Panigrahy, V. Raja Rajeswari, and M. Durga Prakash: resources; B. Vamsi Krsihna, (A) Gangadhar, S. Ravi, V. Raja Rajeswari, and M. Durga Prakash: data curation; D. Mohan, Asisa Kumar Panigrahy, and M. Durga Prakash: writing—original draft preparation; M. Durga Prakash, (B) Vamsi Krsihna: writing—review and editing; Asisa Kumar Panigrahy, and M. Durga Prakash: visualization; M. Durga Prakash: supervision.
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Date: 05-02-2022.
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Krsihna, B.V., Gangadhar, A., Ravi, S. et al. A Highly Sensitive Graphene-based Field Effect Transistor for the Detection of Myoglobin. Silicon 14, 11741–11748 (2022). https://doi.org/10.1007/s12633-022-01790-9
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DOI: https://doi.org/10.1007/s12633-022-01790-9