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A Study of an Ultrasensitive Label Free Silicon Nanowire FET Biosensor for Cardiac Troponin I Detection

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Abstract

This study evolves an ultrasensitive label free electrical device, the silicon nanowire field effect transistor (SiNW FET) for cardiac troponin I (cTnI) in acute myocardial infarction (AMI). In this work, SiNW FET is designed, simulated using COMSOL semiconductor module to identify the presence of different concentrations of cTnI present in human blood. The surface of the SiNW is functionalized with the cTnI monoclonal antibody (mAb-cTnI) on attached to detect cTnI antigen. The response of the device is also studied using cTnI at different concentrations with the lowest limit of detection of 0.002 ng/mL. The presented SiNW FET in this study shows considerable response than the earlier developed devices and signify impressive capability for subsequent implementation in point-of-care (PoC) detection.

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Aknowledgements

The authors would like to acknowledge Indian Institute of Technology Hyderabad (IIT Hyderabad) for backing us with some experimental work carried out and the tool (COMSOL Semiconductor Module) required for simulating this work. And M. Durga Prakash thankfully acknowledges this publication as an outcome of the R&D work undertaken project under the Start-up Research Grant (File No.: SRG/2019/002236) Scheme of Department of Science and Technology (DST), Government of India, being Science Engineering Research Broad (SERB).

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Authors and Affiliations

  1. Department of ECE, Velagapudi Ramakrishna Siddhartha Engineering College, Kanuru, 520007, Andhra Pradesh, India

    M. Durga Prakash & Shaik Ahmadsaidulu

  2. Department of ECE, Koneru Lakshmaih Education Foundation, 522502, Guntur, Andhra Pradesh, India

    B. Vamsi Krsihna

  3. Department of ECE, Vishnu Institute of Technology, Vishnupur, Bhimavaram, 534202, Andhra Pradesh, India

    B. V. V. Satyanarayana

  4. Department of ECE, Gokaraju Rangaraju Institute of Engineering & Technology, 500090, Hyderabad, Telangana, India

    N. Arun Vignesh & Asisa Kumar Panigrahy

Authors
  1. M. Durga Prakash
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  2. B. Vamsi Krsihna
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  3. B. V. V. Satyanarayana
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  4. N. Arun Vignesh
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  5. Asisa Kumar Panigrahy
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  6. Shaik Ahmadsaidulu
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Contributions

M. Durga Prakash and Shaik Ahmadsaidulu: Conceptualization; M. Durga Prakash and Shaik Ahmadsaidulu: investigation; M. Durga Prakash, Shaik Ahmadsaidulu, B. Vamsi Krsihna, N. Arun Vignesh, Asisa Kumar Panigrahy, and B V V Satyanarayana: resources; M. Durga Prakash, Shaik Ahmadsaidulu, B. Vamsi Krsihna, N. Arun Vignesh and B V V Satyanarayana: data curation; M. Durga Prakash, N. Arun Vignesh, Asisa Kumar Panigrahy and Shaik Ahmadsaidulu: writing—original draft preparation; M. Durga Prakash, N. Arun Vignesh, and Shaik Ahmadsaidulu: writing—review and editing; M. Durga Prakash and Shaik Ahmadsaidulu: visualization; M. Durga Prakash: supervision;

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Correspondence to M. Durga Prakash or Shaik Ahmadsaidulu.

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Prakash, M.D., Krsihna, B.V., Satyanarayana, B.V.V. et al. A Study of an Ultrasensitive Label Free Silicon Nanowire FET Biosensor for Cardiac Troponin I Detection. Silicon 14, 5683–5690 (2022). https://doi.org/10.1007/s12633-021-01352-5

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