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Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement

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Abstract

Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma characterized by specific morphological and immunophenotypic features. The basic genetic feature of BL is the rearrangement of MYC gene, visible as t(8;14)(q24;q32) translocation or its variant. However, some lymphomas with characteristic BL morphology are nowadays diagnosed as B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL (Inter-DLBCL/BL) for biological or clinical reasons. We present four lymphomas without the MYC rearrangement presented typical Burkitt morphology, FCM immunophenotype with some deviations when compared to a typical BL. The cases were finally diagnosed as Inter-DLBCL/BL. All of them presented a recurrent abnormality within the chromosome 11: dup(11)(q23q13). We suppose that the dup(11)(q23q13), in absence of the MYC gene rearrangement, is connected with borderline lymphomas with a morphology similar or identical to that of the Burkitt lymphoma. Identifying such an aberration may be helpful in the diagnostics of Inter-DLBCL/BL eventually forming a distinct subgroup of lymphomas.

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Authors and Affiliations

  1. Cytogenetic Laboratory, MSCM Cancer Centre and Institute, 5 W.K. Roentgen Str., 02-781, Warsaw, Poland

    Barbara Pienkowska-Grela, Beata Grygalewicz, Renata Woroniecka & Paulina Krawczyk

  2. Flow Cytometry Laboratory, MSCM Cancer Centre and Institute, Warsaw, Poland

    Grzegorz Rymkiewicz

  3. Department of Lymphoprolipherative Disease, MSCM Cancer Centre and Institute, Warsaw, Poland

    Katarzyna Czyz-Domanska & Jan Walewski

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  1. Barbara Pienkowska-Grela
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  2. Grzegorz Rymkiewicz
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  3. Beata Grygalewicz
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  4. Renata Woroniecka
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  5. Paulina Krawczyk
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  6. Katarzyna Czyz-Domanska
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  7. Jan Walewski
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Correspondence to Barbara Pienkowska-Grela.

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Pienkowska-Grela, B., Rymkiewicz, G., Grygalewicz, B. et al. Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement. Med Oncol 28, 1589–1595 (2011). https://doi.org/10.1007/s12032-010-9614-0

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  • DOI: https://doi.org/10.1007/s12032-010-9614-0

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