Abstract
This paper surveys the various naturally occurring flavonoids that have been isolated from different natural sources. This is the first petra/osiris/molinspiration (POM) analysis published on this topic. The present study furnishes an overview of the 32 flavonoids and anti-HIV-Integrase activity of their metabolite species. The aqueous and/or ethanol extraction of flavonoids have often been used in traditional medicine, and therefore have also been studied for their antitumor, antioxidant, antiviral, anti-algal, antimicrobial, cytotoxic and anti-inflammatory, and significant hepatoprotective and cardiovascular activity without any criteria of selection. Here, on the basis of POM analyses, a simple, economic, quick and efficient bioinformatic platform, it now becomes easy and possible to predict and optimize flavonoids bioactivity.
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Highlights
1. POM approach provides an intelligent, economic and quick method of identifying hits. 2. Flavonoids which may be modulated to inhibit viral HIV replication. 3. Elucidation of antiviral mechanism of flavonoids for treating viral infections.
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Hadda, T.B., Fergoug, T., Warad, I. et al. POM as a quick bioinformatic platform to select flavonoids and their metabolites as potential and efficient HIV-1 integrase inhibitors. Res Chem Intermed 39, 1227–1244 (2013). https://doi.org/10.1007/s11164-012-0679-6
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DOI: https://doi.org/10.1007/s11164-012-0679-6