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Orthogonal array design for optimization of hollow-fiber-based liquid-phase microextraction combined with high-performance liquid chromatography for study of the pharmacokinetics of magnoflorine in rat plasma

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Abstract

In this work, a new sample-preparation method based on hollow-fiber liquid-phase microextraction (HF-LPME) was developed for analysis of magnoflorine in rat plasma. Analysis was accomplished by reversed-phase high-performance liquid chromatography (HPLC), with ultraviolet detection by use of a photodiode-array detector. An orthogonal array design (OAD) was found to be effective for optimization of major conditions which may affect the efficiency of HF-LPME. Under the optimized conditions (pH of donor and acceptor phases 12 and 2.0, respectively; extraction time 20 min; stirring speed 800 rpm; and addition of 10 % (w/v) salt), the preconcentration factor for magnoflorine was 355. Calibration curves with reasonable linearity (r 2 ≥ 0.9994) were obtained in the range 10–1000 ng mL−1. Intra-day and inter-day precision (RSD) were <5.5 % and the limit of detection (LOD) for the analyte was 3.0 ng mL−1 (S/N = 3). The validated method was successfully used for pharmacokinetic studies of magnoflorine in rat plasma after intravenous administration.

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Authors and Affiliations

  1. Department of Pharmacy, Urumqi General Hospital of PLA, Urumqi, **njiang, 830000, China

    Jun Zhou, **g Liu, Zhao Hui Cheng & ** Zeng

  2. Department Clinical Laboratory, NO.23 Hospital of PLA, Urumqi, **njiang, 830000, China

    Jiang Bing Sun

  3. Department of Information, Urumqi General Hospital of PLA, Urumqi, **njiang, 830000, China

    ** Zheng

  4. Department of chemistry, Fourth Military Medical University, **’an, Shanxi, 710032, China

    Feng Qiao Wang

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  1. Jun Zhou
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  2. Jiang Bing Sun
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  3. ** Zheng
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  4. **g Liu
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  5. Zhao Hui Cheng
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  6. ** Zeng
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  7. Feng Qiao Wang
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Correspondence to ** Zeng or Feng Qiao Wang.

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Zhou, J., Sun, J.B., Zheng, P. et al. Orthogonal array design for optimization of hollow-fiber-based liquid-phase microextraction combined with high-performance liquid chromatography for study of the pharmacokinetics of magnoflorine in rat plasma. Anal Bioanal Chem 403, 1951–1960 (2012). https://doi.org/10.1007/s00216-012-6013-8

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  • DOI: https://doi.org/10.1007/s00216-012-6013-8

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