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Central Composite Design for Optimizing Hollow Fiber Liquid Phase Microextraction of Carbamazepine from Aqueous and Biological Samples

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Abstract

A simple, sensitive and efficient method based on hollow fiber liquid phase microextraction followed by high performance liquid chromatography has been developed for preconcentration and determination of trace carbamazepine, an antiepileptic drug, in aqueous and biological solutions.The main parameters affecting the extraction efficiency were studied using response surface methodology. Central composite design was performed at five levels of extraction time, pH and ionic strength. The final model showed good linearity and performance. The optimal conditions were observed at 48.5 min, 8.9 and 0.29 M for extraction time, pH and ionic strength, respectively. The calibration curve was linear in the range of 5–500 µg/L with correlation coefficient of 0.9999 and limit of detection of 2.8 µg/L. Finally, the applicability of the proposed method was evaluated by extraction and determination of the drug in aqueous and plasma samples. The intra- and inter-day coefficients of variation were less than 4.7 for all real samples.

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Funding

Financial support by Rasht Branch, Islamic Azad University Grant No. 4.5830 is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Medical Biotechnology, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran

    Elahe Bozorgzadeh

  2. Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

    Shahab Shariati & Azita Esmaeilnejad

Authors
  1. Elahe Bozorgzadeh
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  2. Shahab Shariati
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  3. Azita Esmaeilnejad
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Corresponding author

Correspondence to Shahab Shariati.

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Elahe Bozorgzadeh, Shariati, S. & Esmaeilnejad, A. Central Composite Design for Optimizing Hollow Fiber Liquid Phase Microextraction of Carbamazepine from Aqueous and Biological Samples. J Anal Chem 75, 154–160 (2020). https://doi.org/10.1134/S1061934820020033

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