Log in

Antimutagenicity of milk fermented byEnterococcus fœcium

  • Published:
Folia Microbiologica Aims and scope Submit manuscript

Abstract

The diethyl ether extracts isolated from unfermented milk and milk fermented byEnterococcus fœcium exhibited dose-dependent inhibition of mutagenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), nitrovin (NIT), 5-nitro-2-furylacrylic acid (NFA) and UV-irradiation on the Ames bacterial test (Salmonella typhimurium strains TA97 and TA100) and the unicellular flagellateEuglena gracilis. Overall, the fermented milk extract was the most active against UV-irradiation, less active against NIT and MNNG, and the least active against NFA on bacteria. The highest antibleaching effects were observed against MNNG. The differences between antimutagenic effects from fermented and unfermented milk extracts were determined to be statistically significant at the 0.95 CI level.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Agerbaek M., Gerdes L.U., Richelsen B.: Hypocholesterolæmic effect of a new fermented milk product in healthy middleaged men.Eur. J. Clin. Nutr.49, 346–352 (1995).

    PubMed  CAS  Google Scholar 

  • Ebringer L.: Interaction of drugs with extracellular genetic elements and its consequences.Teratogen. Carcinogen. Mutagen.10, 477–501 (1990).

    Article  CAS  Google Scholar 

  • Ebringer L., Polónyi J., Krajčovič J.: Influence of ofloxacin on chloroplasts and mitochondria inEuglena gracilis.Drug Res.43, 777–781 (1993).

    CAS  Google Scholar 

  • Ebringer L., Ferenčík M., Lahitová N., Kačáni L., Michálková D.: Anti-mutagenic and immuno-stimulatory properties of lactic acid bacteria.World J. Microbiol. Biotechnol.11, 294–298 (1995).

    Article  Google Scholar 

  • Foltinová P., Lahitová N., Ebringer L.: Antimutagenicity inEuglena gracilis.Mutat. Res.323, 167–171 (1994).

    Article  PubMed  Google Scholar 

  • Foltinová P., Grones J.:Euglena gracilis as an eukaryotic test organism for detecting mutagens and antimutagens.Mutat. Res.393, 1–6 (1997).

    PubMed  Google Scholar 

  • Hosoda M., Hashimoto H., Morita H., Chiba M., Hosono A.: Antimutagenicity of milk cultured with lactic acid bacteria against N-methyl-N′-nitro-N-nitrosoguanidine.J. Dairy Sci.75, 976–981 (1992a).

    Article  PubMed  CAS  Google Scholar 

  • Hosoda M., Hashimoto H., Morita H., Chiba M., Hosono A.: Studies on antimutagenic effect of milk cultured with lactic acid bacteria on the Trp-P2-induced mutagenicity to TA98 strain ofSalmonella typhimurium.J. Dairy Res.59, 543–549 (1992b).

    Article  PubMed  CAS  Google Scholar 

  • Hosoda M., Hashimoto H., He F., Yamazaki K., Hosono A.: Inhibitory effect of milk cultured withLactobacillus strains on the aflatoxin mutagenicity.Animal Sci. Technol.68, 555–562 (1997).

    CAS  Google Scholar 

  • Hosono A., Shirai H.: Antimutagenicity of milk cultured with lactic bacteria against the heated solution of cysteine-glucose.Animal Sci. Technol.67, 1076–1081 (1996).

    CAS  Google Scholar 

  • Loguercio C., Abbiati R., Rinaldi M., Romano A., Blanco C.V., Coltorti M.: Long-term effects ofEnterococcus fœcium SF68versus lactulose in the treatment of patients with cirrhosis and grade 1–2 hepatic encephalopathy.J. Hepatol.23, 39–46 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Maron D.M., Ames B.N.: Revised methods for theSalmonella mutagenicity test.Mutat. Res.143, 173–215 (1983).

    Google Scholar 

  • Matar C., Nadathus S.S., Bakalinsky A.T., Goulet J.: Antimutagenic effects of milk fermented byLactobacillus helveticus L89 and a protease-deficient derivative.J. Dairy Sci.80, 1965–1970 (1997).

    PubMed  CAS  Google Scholar 

  • Mikeš Z., Ferenčik M., Jahnová Z., Ebringer L..,Čižnár I.: Hypocholesterolemic and immunostimulatory effects of orally appliedEnterococcus fœcium M-74 in man.Folia Microbiol.40, 639–646 (1995).

    Google Scholar 

  • Nadathur S.R., Gould S.J., Bakalinsky A.T.: Antimutagenicity of fermented milk.J. Dairy Sci.77, 3287–3295 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Nadathur S.R., Gould S.J., Bakalinsky A.T.: Antimutagenicity of an acetone extract of yogurt.Mutat. Res.334, 213–224 (1995).

    PubMed  CAS  Google Scholar 

  • Olasupo N.A.: Inhibition ofListeria monocytogenes by plantaricin NA, an, antibacterial substance fromLactobacillus plantarum.Folia Microbiol.43, 151–154 (1998).

    CAS  Google Scholar 

  • Pool-Zobel B.L., Bertram B., Knoll M., Lambertz R., Neudecker C., Schillinger U., Schmezer P., Holzapfel W.H.: Antigenotoxic properties of lactic acids bacteriain vivo in the gastrointestinal tract of rats.Nutr. Cancer20, 271–281 (1993).

    PubMed  CAS  Google Scholar 

  • Pool-Zobel B.L., Münzner R., Holzapfel W.H.: Antigenotoxic properties of lactic acid bacteria in theS. typhimurium mutagenicity assay.Nutr. Cancer20, 261–270 (1993).

    PubMed  CAS  Google Scholar 

  • Pool-Zobel B.L., Neudecker C., Domizlaff I., Ji S., Schillinger U., Rumney C., Moretti M., Vilarini I., Scassellati-Sforzolini R., Rowland I.:Lactobacillus andbifidobacterium-mediated antigenotoxicity in the colon of rats.Nutr. Cancer26, 365–380 (1996).

    PubMed  CAS  Google Scholar 

  • Reddy B.S., Rivenson A.: Inhibitory effect ofBifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methyl-imidazo[4,5f]quinoline, and food mutagen.Cancer Res.53, 3914–3918 (1993).

    PubMed  CAS  Google Scholar 

  • Rice L.J., Chai Y.J., Conti C.J., Willis R.A., Locniskar M.F.: The effect of dietary fermented milk products and lactic acid bacteria on the initiation and promotion stages of mammary carcinogenesis.Nutr. Cancer24, 99–109 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Richelsen B., Agerbaek M., Gerdes L.U.: Cholesterol-lowering effect of a new fermented milk product in healthy 44-year old Danish men.Ugeskr. Lœger20, 3015–3019 (1993).

    Google Scholar 

  • Richelsen B., Kristensen K., Pedersen S.B.: Long-term (6 months) effect of a new fermented milk product on the level of plasma lipoproteins—a placebo-controlled and double blind study.Eur. J. Clin. Nutr.50, 811–815 (1996).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Belicová.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Belicová, A., Krajčovič, J., Dobias, J. et al. Antimutagenicity of milk fermented byEnterococcus fœcium . Folia Microbiol 44, 513–518 (1999). https://doi.org/10.1007/BF02816252

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02816252

Keywords

Navigation