Abstract
Statistically significant antigenotoxic activity was exerted by six of nine strains of lactic acid bacteria tested (Lactobacillus delbrueckii subsp. bulgaricus, Staphylococcus carnosus, Streptococcus thermophilus, L. rhamnosus, Enterococcus faecium and En. faecalis) against nitrovin and 2-aminofluorene in Salmonella typhimurium TA100 and TA97. The mutagenic activity of both mutagens was substantially decreased by viable bacteria; cells heated to 100°C for 15 min were ineffective. In vitro, En. faecium stimulated the basic metabolic activities of human neutrophils which were essential for their antimicrobial and cytotoxic activity, whereas stimulation of guinea-pig macrophages was not so effective. Similar immuno-stimulatory effects were observed with both viable and heat-inactivated bacteria.
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L. Ebringer, M. Lahitová and D. Michálková are with the Institute of Molecular and Subcellular Biology, Comenius University, Odborárske nám. 5, SK-81107 Bratislava, Slovakia. M. Ferenčík and L. Kačáni are with the Institute of Immunology, Faculty of Medicine, Comenius University, SK-81108 Bratislava, Slovakia.
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Ebringer, L., Ferenčík, M., Lahitová, N. et al. Anti-mutagenic and immuno-stimulatory properties of lactic acid bacteria. World Journal of Microbiology & Biotechnology 11, 294–298 (1995). https://doi.org/10.1007/BF00367102
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DOI: https://doi.org/10.1007/BF00367102