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The Inhibitory Activity of Lactobacillus plantarum Supernatant against Enterobacteria, Campylobacter, and Tumor Cells

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Cell-free supernatant of Lactobacillus plantarum exhibit a strong antimicrobial effect against a number of pathogenic enterobacteria (E. coli, Shigella flexneri, Salmonella typhimurium, Proteus mirabilis, and Campylobacter jejuni). The degree of growth inhibition in broth culture reached a high level for all tested bacteria. The highest rates were noted for P. mirabilis (by 13 times) and the lowest for S. flexneri (by 5 times) and C. jejuni (by 4.5 times). Significant antiproliferative effect of the supernatant on cells of tumor-derived epithelial cell lines was shown. The highest degree of inhibition (by 22 times) was observed for HT-29 cells (colon carcinoma). Thus, inclusion of probiotics in traditional treatment schemes can increase the effectiveness of antibacterial and antitumor drug therapy.

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Authors and Affiliations

  1. Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia

    T. A. Danilova, A. A. Adzhieva, M. V. Mezentseva, I. A. Suetina, G. A. Danilina, A. G. Minko, M. L. Dmitrieva & V. G. Zhukhovitsky

  2. Department of Clinical and Laboratory Diagnosis with Laboratory Immunology Course, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia

    V. G. Zhukhovitsky

Authors
  1. T. A. Danilova
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  2. A. A. Adzhieva
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  3. M. V. Mezentseva
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  4. I. A. Suetina
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  5. G. A. Danilina
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  6. A. G. Minko
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  7. M. L. Dmitrieva
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  8. V. G. Zhukhovitsky
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Correspondence to T. A. Danilova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 7, pp. 76-80, July, 2023

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Danilova, T.A., Adzhieva, A.A., Mezentseva, M.V. et al. The Inhibitory Activity of Lactobacillus plantarum Supernatant against Enterobacteria, Campylobacter, and Tumor Cells. Bull Exp Biol Med 176, 64–67 (2023). https://doi.org/10.1007/s10517-023-05969-x

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