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Considerations on the recognition of the D1 receptor by agonists

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Summary

A model of the mechanism for recognition of the D1 receptor has been developed. Conformational analysis for 10 agonists from diverse chemical families was carried out as a first step toward the characterization of the bioactive form. First, maximum structural overlap of the features common to all ligands allowed a simple identification of the candidate bioactive form for each ligand. At a second level of characterization, steric and electronic properties were computed for all accessible structures to analyze those properties that may modulate receptor recognition.

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Author notes

  1. Hugo O. Villar

    Present address: Terrapin Technologies Inc., 750-H Gateway Blvd., 94080, South San Francisco, CA, U.S.A.

Authors and Affiliations

  1. Molecular Research Institute, 845 Page Mill Road, 94304, Palo Alto, CA, U.S.A.

    Ibon Alkorta & Hugo O. Villar

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  1. Ibon Alkorta
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Alkorta, I., Villar, H.O. Considerations on the recognition of the D1 receptor by agonists. J Computer-Aided Mol Des 7, 659–670 (1993). https://doi.org/10.1007/BF00125324

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  • DOI: https://doi.org/10.1007/BF00125324

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