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Metabolic Status and Reaction to Heat of Normal and Tumor Tissue

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Thermoradiotherapy and Thermochemotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The occurrence of differential heating and differential thermal sensitivity between malignant tumors and normal tissues is thought to be due to limited heat dissipation and energy depletion in many solid tumors which in turn results from an inadequately functioning tumor microcirculation (Jain and Ward-Hartley 1984; Song 1984, 1991; Vaupel and Kallinowski 1987; Reinhold 1988; Vaupel et al. 1988a; Vaupel 1990). As a consequence of the latter pathophysiological condition, supply and drainage function are restricted in many solid tumors or, at least, in some tumor areas, thus creating a hostile metabolic microenvironment characterized by tissue hypoxia, acidosis, and energy depletion. Thermal sensitivity has been shown to depend greatly on tumor pH, and on energy and nutritional status of the tumors treated. Although no conclusive evidence is so far available concerning the ranking of these pivotal factors, there is no doubt that the rate and homogeneity of blood perfusion plays a paramount role in determining the metabolic and energy status.

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, Universität Mainz, Duesbergweg 6, D-55099, Mainz, Germany

    P. W. Vaupel Dr. MD, Professor & D. K. Kelleher PhD

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  1. P. W. Vaupel Dr. MD, Professor
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  2. D. K. Kelleher PhD
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Editors and Affiliations

  1. Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    M. Heinrich Seegenschmiedt

  2. Radiation Oncology Physics Division, Stanford University Medical Center, SUMC Room S-044, Stanford, CA, 94305, USA

    Peter Fessenden PhD (Professor Emeritus, Radiation Oncology) (Professor Emeritus, Radiation Oncology)

  3. Department of Clinical Oncology, Hammersmith Hospital, Ducane Road, London, W12 OHS, UK

    Clare C. Vernon MA, FRCR

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© 1995 Springer-Verlag Berlin Heidelberg

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Vaupel, P.W., Kelleher, D.K. (1995). Metabolic Status and Reaction to Heat of Normal and Tumor Tissue. In: Seegenschmiedt, M.H., Fessenden, P., Vernon, C.C. (eds) Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57858-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-57858-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63382-9

  • Online ISBN: 978-3-642-57858-8

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