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Pathophysiological Mechanisms of Hyperthermia in Cancer Therapy

  • Chapter
Biological Basis of Oncologic Thermotherapy

Part of the book series: Clinical Thermology ((1289))

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Abstract

Increasing evidence supports the notion that malignant tumors can be damaged by a thermal dose which is innoxious to normal tissues. This preferential damage in tumors by hyperthermia is believed to be related to properties such as tumor blood flow (XBF), tissue oxygenation, pH distribution, and energy status — factors which generally go hand in hand, and in turn define the cellular microenvironment. Whether or not normal and malignant cells have different inherent thermosensitivities is still a controversial subject (Dethlefsen and Dewey 1982; Hahn 1982; Storm 1983).

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  1. Laboratoire de Thermologie Biomédicale, Université Louis Pasteur Institut National de la Santé et de la Recherche Médicale, 11, rue Humann, 67085, Strasbourg Cedex, France

    Michel Gautherie

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Vaupel, P. (1990). Pathophysiological Mechanisms of Hyperthermia in Cancer Therapy. In: Gautherie, M. (eds) Biological Basis of Oncologic Thermotherapy. Clinical Thermology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74939-1_2

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