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Antimicrobial Drug Resistance

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Comparative and Veterinary Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 199))

Abstract

This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a matrix of complex variables that includes the mechanism of drug action, the pharmacokinetics (PK) of the antimicrobial agent in the targeted patient population, the pharmacodynamics (PD) of the bacterial response to the antimicrobial agent, the PK/PD relationship that will influence dose selection, and the integrity of the host immune system. Finally, the differences between bacterial tolerance and bacterial resistance are considered, and the potential for non-traditional anti-infective therapies is discussed.

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Authors and Affiliations

  1. Office of New Animal Drug Evaluation (HFV-130), Center for Veterinary Medicine Food and Drug Administration, 7500 Standish Place, Rockville, MD, 20855, USA

    Marilyn Martinez

  2. MB Consult Limited, Enterprise House, Ocean Village, Southampton, Hampshire, SO14 3XB, UK

    Peter Silley

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  1. Marilyn Martinez
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  2. Peter Silley
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Correspondence to Marilyn Martinez .

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Editors and Affiliations

  1. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Fiona Cunningham

  2. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Jonathan Elliott

  3. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Peter Lees

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Martinez, M., Silley, P. (2010). Antimicrobial Drug Resistance. In: Cunningham, F., Elliott, J., Lees, P. (eds) Comparative and Veterinary Pharmacology. Handbook of Experimental Pharmacology, vol 199. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10324-7_10

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