Abstract
Antimicrobial resistance has not been a new phenomenon. Still, the number of resistant organisms, the geographic areas affected by emerging drug resistance, and the magnitude of resistance in a single organism are enormous and mounting. Disease and disease-causing agents formerly thought to be contained by antibiotics are now returning in new forms resistant to existing therapies. Antimicrobial resistance is one of the most severe and complicated health issues globally, driven by interrelated dynamics in humans, animals, and environmental health sectors. Coupled with various epidemiological factors and a limited pipeline for new antimicrobials, all these misappropriations allow the transmission of drug-resistant organisms. The problem is likely to worsen soon. Antimicrobial resistance in general and antibiotic resistance in particular is a shared global problem. Actions taken by any single country can adversely or positively affect the other country. Targeted coordination and prevention strategies are critical in stop** the spread of antibiotic-resistant organisms and hence its overall management. This article has provided in-depth knowledge about various methods that can help mitigate the emergence and spread of antimicrobial resistance globally.
Key points
• Overview of antimicrobial resistance as a global challenge and explain various reasons for its rapid progression.
• Brief about the intrinsic and acquired resistance to antimicrobials and development of antibiotic resistance in bacteria.
• Systematically organized information is provided on different strategies for tackling antimicrobial resistance for the welfare of human health.
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References
Akova M (2016) Epidemiology of antimicrobial resistance in bloodstream infections. Virulence 7(3):252–266. https://doi.org/10.1080/21505594.2016.1159366
Alcayaga-Miranda F, Cuenca J, Khoury M (2017) Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies. Front Immunol 8:339. https://doi.org/10.3389/fimmu.2017.0033
Al-Hamad A, Burnie J, Upton M (2011) Enhancement of antibiotic susceptibility of Stenotrophomonas maltophilia using a polyclonal antibody developed against an ABC multidrug efflux pump. Can J Microbiol 57(10):820–828. https://doi.org/10.1139/w11-076
Andersson DI, Balaban NQ, Baquero F, Courvalin P, Glaser P, Gophna U, Kishony R, Molin S, Tønjum T (2020) Antibiotic resistance: turning evolutionary principles into clinical reality. FEMS Microbiol Rev 44(2):171–188
Ando H, Lemire S, Pires DP, Lu TK (2015) Engineering modular viral scaffolds for targeted bacterial population editing. Cell Syst 1(3):187–196. https://doi.org/10.1016/j.cels.2015.08.013
Aslam B, Wang W, Arshad MI, Khurshid M, Muzammil S, Rasool MH, Nisar MA, Alvi RF, Aslam MA, Qamar MU (2018) Antibiotic resistance: a rundown of a global crisis. Infect Drug Resist 11:1645. https://doi.org/10.2147/IDR.S173867
Azad RK, Mishra N, Ahmed F, Kaundal R (2014) Bioinformatics Approaches to Deciphering Alien Gene Transfer: A Comprehensive Analysis Alien Gene Transfer in Crop Plants, Volume 1. Springer, New York, p 267–287
Baptista PV, McCusker MP, Carvalho A, Ferreira DA, Mohan NM, Martins M, Fernandes AR (2018) Nano-strategies to fight multidrug resistant bacteria—“A Battle of the Titans.” Front Microbiol 9:1441. https://doi.org/10.3389/fmicb.2018.01441
Baquero F, Lanza VF, Cantón R, Coque TM (2015) Public health evolutionary biology of antimicrobial resistance: priorities for intervention. Evol Appl 8(3):223–239. https://doi.org/10.1111/eva.12235
Baquero F (2007) Topical Debates Evaluation of Risks and Benefits of Consumption of Antibiotics: From Individual to Public Health. Encyclopedia of Infectious Diseases: Modern Methodologies:509–516. https://doi.org/10.1002/9780470114209.ch30
Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA, Horvath P (2007) CRISPR provides acquired resistance against viruses in prokaryotes. Science 315(5819):1709–1712. https://doi.org/10.1126/science.1138140
Baur D, Gladstone BP, Burkert F, Carrara E, Foschi F, Döbele S, Tacconelli E (2017) Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis. Lancet Infect Dis 17(9):990–1001. https://doi.org/10.1016/S1473-3099(17)30325-0
Begier E, Seiden DJ, Patton M, Zito E, Severs J, Cooper D, Eiden J, Gruber WC, Jansen KU, Anderson AS (2017) SA4Ag, a 4-antigen Staphylococcus aureus vaccine, rapidly induces high levels of bacteria-killing antibodies. Vaccine 35(8):1132–1139. https://doi.org/10.1016/j.vaccine.2017.01.024
Bhat BA, Mir WR, Sheikh BA, Rather MA, Mir MA (2022) In vitro and in silico evaluation of antimicrobial properties of Delphinium cashmerianum L., a medicinal herb growing in Kashmir, India. J Ethnopharmacol 291:115046
Bikard D, Euler CW, Jiang W, Nussenzweig PM, Goldberg GW, Duportet X, Fischetti VA, Marraffini LA (2014) Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol 32(11):1146–1150. https://doi.org/10.1038/nbt.3043
Branche A, Neeser O, Mueller B, Schuetz P (2019) Procalcitonin to guide antibiotic decision making. Curr Opin Infect Dis 32(2):130–135. https://doi.org/10.1097/QCO.0000000000000522
Bronzwaer S, Goettsch W, Olsson-Liljequist B, Wale MCJ, Vatopoulos A, Sprenger MJW (1999) European antimicrobial resistance surveillance system (EARSS): objectives and organisation. Eurosurveillance 4(4):41–44. https://doi.org/10.2807/esm.04.04.00066-en
Cangini A, Fortinguerra F, Di Filippo A, Pierantozzi A, Da Cas R, Villa F, Trotta F, Moro ML, Gagliotti C (2020) Monitoring the community use of antibiotics in Italy within the National Action Plan on Antimicrobial Resistance. Br J Clin Pharmacol. https://doi.org/10.1111/bcp.14461
Chellat MF, Raguž L, Riedl R (2016) Targeting antibiotic resistance. Angew Chem Int Ed 55(23):6600–6626. https://doi.org/10.1002/anie.201506818
Citorik RJ, Mimee M, Lu TK (2014) Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat Biotechnol 32(11):1141–1145. https://doi.org/10.1038/nbt.3011
Das B, Sajid KMT, Sharif RM, Shaila U, Das TK, Tanim CZH (2022) Detection of Quinolone Resistance Qnr Genes and its Association with Extended Spectrum Β-Lactamase and Carbapenemase Genes in Qnr Positive Enterobacteriaceae in a Tertiary Hospital in Bangladesh. Sch J App Med Sci 4:450–457. https://doi.org/10.36347/sjams.2022.v10i04.001
David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, Abudahab K, Goater R, Giani T, Errico G (2019) Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol 4(11):1919–1929. https://doi.org/10.1038/s41564-019-0492-8
DeFilipp Z, Bloom PP, Torres Soto M, Mansour MK, Sater MR, Huntley MH, Turbett S, Chung RT, Chen Y-B, Hohmann EL (2019) Drug-resistant E coli bacteremia transmitted by fecal microbiota transplant. N Engl J Med. 381(21):2043–2050. https://doi.org/10.1056/NEJMoa1910437
DeNegre AA, Ndeffo Mbah ML, Myers K, Fefferman NH (2019) Emergence of antibiotic resistance in immunocompromised host populations: A case study of emerging antibiotic resistant tuberculosis in AIDS patients. PLoS ONE 14(2). https://doi.org/10.1371/journal.pone.0212969
Domalaon R, Idowu T, Zhanel GG, Schweizer F (2018) Antibiotic hybrids: the next generation of agents and adjuvants against gram-negative pathogens? Clin Microbiol Rev 31(2):e00077-17
Dorado-García A, Mevius DJ, Jacobs JJ, Van Geijlswijk IM, Mouton JW, Wagenaar JA, Heederik DJ (2016) Quantitative assessment of antimicrobial resistance in livestock during the course of a nationwide antimicrobial use reduction in the Netherlands. J Antimicrob Chemother 71(12):3607–3619. https://doi.org/10.1093/jac/dkw308
Drlica K, Zhao X (2007) Mutant selection window hypothesis updated. Clin Infect Dis 44(5):681–688. https://doi.org/10.1086/511642
Gerding DN, Larson TA, Hughes RA, Weiler M, Shanholtzer C, Peterson LR (1991) Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital. Antimicrob Agents Chemother 35(7):1284–1290. https://doi.org/10.1128/AAC.35.7.1284
Getino M, De la cruz F (2018) Natural and artificial strategies to control the conjugative transmission of plasmids. Microbiology spectrum 6(1):6–1
Ghosh C, Sarkar P, Issa R, Haldar J (2019) Alternatives to conventional antibiotics in the era of antimicrobial resistance. Trends Microbiol 27(4):323–338. https://doi.org/10.1016/j.tim.2018.12.010
Gopalsamy SN, Woodworth MH, Wang T, Carpentieri CT, Mehta N, Friedman-Moraco RJ, Mehta AK, Larsen CP, Kraft CS (2018) The use of microbiome restoration therapeutics to eliminate intestinal colonization with multidrug-resistant organisms. Am J Med Sci 356(5):433–440. https://doi.org/10.1016/j.amjms.2018.08.015
Goren M, Yosef I, Qimron U (2017) Sensitizing pathogens to antibiotics using the CRISPR-Cas system. Drug Resist Updates 30:1–6. https://doi.org/10.1016/j.drup.2016.11.001
Goren I, Godny L, Reshef L, Yanai H, Gophna U, Tulchinsky H, Dotan I (2019) Starch consumption may modify antiglycan antibodies and fecal fungal composition in patients with ileo-anal pouch. Inflamm Bowel Dis 25(4):742–749. https://doi.org/10.1093/ibd/izy370
Harman RM, Yang S, He MK, Van de Walle GR (2017) Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds. Stem Cell Res Ther 8(1):1–14. https://doi.org/10.1186/s13287-017-0610-6
Harris SR, Cole MJ, Spiteri G, Sánchez-Busó L, Golparian D, Jacobsson S, Goater R, Abudahab K, Yeats CA, Bercot B (2018) Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey. Lancet Infect Dis 18(7):758–768. https://doi.org/10.1016/S1473-3099(18)30225-1Get
Hassan AHE, Kim HJ, Gee MS, Park J-H, Jeon HR, Lee CJ, Choi Y, Moon S, Lee D, Lee JK (2022) Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases. J Enzyme Inhib Med Chem 37(1):768–780. https://doi.org/10.1080/14756366.2022.2036737
Hughes D, Andersson DI (2012) Selection of resistance at lethal and non-lethal antibiotic concentrations. Curr Opin Microbiol 15(5):555–560. https://doi.org/10.1016/j.mib.2012.07.005
Huttner A, Gambillara V (2018) The development and early clinical testing of the ExPEC4V conjugate vaccine against uropathogenic Escherichia coli Clin Microbiol Infect 24(10):1046–1050. https://doi.org/10.1016/j.cmi.2018.05.009
Jansen KU, Knirsch C, Anderson AS (2018) The role of vaccines in preventing bacterial antimicrobial resistance. Nat Med 24(1):10–19. https://doi.org/10.1038/nm.4465
** L, **e J, He T, Wu D, Li X (2021) Airborne transmission as an integral environmental dimension of antimicrobial resistance through the “One Health” lens. Critical Reviews in Environmental Science and Technology:1–22. https://doi.org/10.1080/10643389.2021.2006537
Kang YK, Kwon K, Ryu JS, Lee HN, Park C, Chung HJ (2017) Nonviral genome editing based on a polymer-derivatized CRISPR nanocomplex for targeting bacterial pathogens and antibiotic resistance. Bioconjug Chem 28(4):957–967. https://doi.org/10.1021/acs.bioconjchem.6b00676
Kash JC, Taubenberger JK (2015) The role of viral, host, and secondary bacterial factors in influenza pathogenesis. Am J Pathol 185(6):1528–1536. https://doi.org/10.1016/j.ajpath.2014.08.030
Kortright KE, Chan BK, Koff JL, Turner PE (2019) Phage therapy: a renewed approach to combat antibiotic-resistant bacteria. Cell Host Microbe 25(2):219–232. https://doi.org/10.1016/j.chom.2019.01.014
Kraemer SA, Ramachandran A, Perron GG (2019) Antibiotic pollution in the environment: from microbial ecology to public policy. Microorganisms 7(6):180. https://doi.org/10.3390/microorganisms7060180
Lagier J-C, Khelaifia S, Alou MT, Ndongo S, Dione N, Hugon P, Caputo A, Cadoret F, Traore SI, Dubourg G (2016) Culture of previously uncultured members of the human gut microbiota by culturomics. Nat Microbiol 1(12):1–8. https://doi.org/10.1038/nmicrobiol.2016.203
Levin BR, Baquero F, Ankomah PP, McCall IC (2017) Phagocytes, antibiotics, and self-limiting bacterial infections. Trends Microbiol 25(11):878–892. https://doi.org/10.1016/j.tim.2017.07.005
Lipsitch M, Bergstrom CT, Levin BR (2000) The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions. Proc Natl Acad Sci 97(4):1938–1943. https://doi.org/10.1073/pnas.97.4.1938
Low M, Almog R, Balicer RD, Liberman N, Raz R, Peretz A, Nitzan O (2018) Infectious disease burden and antibiotic prescribing in primary care in Israel. Ann Clin Microbiol Antimicrob 17(1):1–8. https://doi.org/10.1186/s12941-018-0278-5
Maillard JY (2018) Resistance of bacteria to biocides. Microbiology spectrum 6(2):6–2
Mariathasan S, Tan M-W (2017) Antibody–antibiotic conjugates: a novel therapeutic platform against bacterial infections. Trends Mol Med 23(2):135–149. https://doi.org/10.1016/j.molmed.2016.12.008
Masters PA, O’Bryan TA, Zurlo J, Miller DQ, Joshi N (2003) Trimethoprim-sulfamethoxazole revisited. Arch Intern Med 163(4):402–410. https://doi.org/10.1001/archinte.163.4.402
McCarthy SD, Horgan E, Ali A, Masterson C, Laffey JG, MacLoughlin R, O’Toole D (2020) Nebulized mesenchymal stem cell derived conditioned medium retains antibacterial properties against clinical pathogen isolates. J Aerosol Med Pulm Drug Deliv 33(3):140–152. https://doi.org/10.1089/jamp.2019.1542
Mebis J, Goossens H, Bruyneel P, Sion J, Meeus I, Van Droogenbroeck J, Schroyens W, Berneman Z (1998) Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients. Leukemia 12(10):1627–1629. https://doi.org/10.1038/sj.leu.2401158
Michael CA, Gillings MR, Blaskovich MAT, Franks AE (2021) The Antimicrobial Resistance Crisis: An Inadvertent, Unfortunate but Nevertheless Informative Experiment in Evolutionary Biology. Front Ecol Evol 9:1–9. https://doi.org/10.3389/fevo.2021.692674
Minakshi P, Ghosh M, Brar B, Kumar R, Lambe UP, Ranjan K, Manoj J, Prasad G (2019) Nano-antimicrobials: A new paradigm for combating mycobacterial resistance. Curr Pharm Des 25(13):1554–1579. https://doi.org/10.2174/1381612825666190620094041
Mir MA (2015) Develo** costimulatory molecules for immunotherapy of diseases. Academic Press. https://doi.org/10.1016/C2014-0-02898-5
Mir MA (2022) Human Pathogenic Microbes: Diseases and Concerns. Elsevier. https://doi.org/10.1016/C2021-0-02174-X
Mir MA, Bhat BA, Sheikh BA, Rather GA, Mehraj S, Mir WR (2021) Nanomedicine in Human Health Therapeutics and Drug Delivery: Nanobiotechnology and Nanobiomedicine. In applications of Nanomaterials in Agriculture, Food Science, and Medicine. IGI Global, pp 229–251
Mir MA, Hamdani SS, Qadri H (2022a) Significance of immunotherapy for human bacterial diseases and antibacterial drug discovery. Human Pathogen Microbes:129–161. https://doi.org/10.1016/B978-0-323-96127-1.00004-8
Mir MA, Nabi B, Ahlawat S, Kumawat M, Aisha S (2022b) Combating human bacterial infections. Human Pathogen Microbes:71–102. https://doi.org/10.1016/B978-0-323-96127-1.00008-5
Mughini-Gras L, Dorado-García A, van Duijkeren E, van den Bunt G, Dierikx CM, Bonten MJ, Bootsma MC, Schmitt H, Hald T, Evers EG (2019) Attributable sources of community-acquired carriage of Escherichia coli containing β-lactam antibiotic resistance genes: a population-based modelling study. Lancet Planet Health 3(8):e357–e369. https://doi.org/10.1016/S2542-5196(19)30130-5
Mühlen S, Dersch P (2015) Anti-virulence strategies to target bacterial infections How to overcome the antibiotic crisis. Springer, pp 147–183
Nasiruddin M, Neyaz M, Das S (2017) Nanotechnology-based approach in tuberculosis treatment. Tuberculosis Res Treat 2017. https://doi.org/10.1155/2017/4920209
Nemeth J, Oesch G, Kuster SP (2015) Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis. J Antimicrob Chemother 70(2):382–395. https://doi.org/10.1093/jac/dku379
Nguyen AQ, Vu HP, Nguyen LN, Wang Q, Djordjevic SP, Donner E, Yin H, Nghiem LD (2021) Monitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challenges. Sci Total Environ 783:146964. https://doi.org/10.1016/j.scitotenv.2021.146964
Obeid MA, Al Qaraghuli MM, Alsaadi M, Alzahrani AR, Niwasabutra K, Ferro VA (2017) Delivering natural products and biotherapeutics to improve drug efficacy. Ther Deliv 8(11):947–956. https://doi.org/10.4155/tde-2017-0060
Perbandt M, Werner N, Prester A, Rohde H, Aepfelbacher M, Hinrichs W, Betzel C (2022) Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors. Sci Rep 12(1):1–12. https://doi.org/10.1038/s41598-022-09392-6
Pérez-Cobas AE, Artacho A, Knecht H, Ferrús ML, Friedrichs A, Ott SJ, Moya A, Latorre A, Gosalbes MJ (2013) Differential effects of antibiotic therapy on the structure and function of human gut microbiota. PLoS ONE 8(11):e80201. https://doi.org/10.1371/journal.pone.0080201
J Peterson S Garges M Giovanni P McInnes L Wang JA Schloss V Bonazzi JE McEwen KA Wetterstrand C Deal 2009 lunsford RD Wellington CR, Belachew t, Wright m, Giblin c, David h, Mills m, Salomon r, Mullins c, Akolkar b, Begg l, Davis c, Grandison l, Humble m, Khalsa j, Little AR, Peavy h, Pontzer c, Portnoy m, Sayre MH, Starke-Reed p, Zakhari s, Read j, Watson b, Guyer m, NIH HMP Working Group the NIH Human Microbiome Project Genome Research 19 2317 2323. https://doi.org/10.1101/gr.096651.109
Poole K (2012) Bacterial stress responses as determinants of antimicrobial resistance. J Antimicrob Chemother 67(9):2069–2089. https://doi.org/10.1093/jac/dks196
Pursey E, Sünderhauf D, Gaze WH, Westra ER, van Houte S (2018) CRISPR-Cas antimicrobials: Challenges and future prospects. PLoS Pathog 14(6):e1006990. https://doi.org/10.1371/journal.ppat.1006990
Puvača N, de Llanos FR (2021) Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals. Antibiotics 10(1):69. https://doi.org/10.3390/antibiotics10010069
Qadri H, Haseeb A, Mir M (2021) Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes. Curr Drug Targets 22:1–13. https://doi.org/10.2174/1389450121666201228123212
Qasim M, Lim D-J, Park H, Na D (2014) Nanotechnology for diagnosis and treatment of infectious diseases. J Nanosci Nanotechnol 14(10):7374–7387. https://doi.org/10.1166/jnn.2014.9578
Ragheb MN, Thomason MK, Hsu C, Nugent P, Gage J, Samadpour AN, Kariisa A, Merrikh CN, Miller SI, Sherman DR (2019) Inhibiting the evolution of antibiotic resistance. Mol Cell 73(1):157-165e5. https://doi.org/10.1016/j.molcel.2018.10.015
Regoes RR, Wiuff C, Zappala RM, Garner KN, Baquero F, Levin BR (2004) Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimens. Antimicrob Agents Chemother 48(10):3670–3676. https://doi.org/10.1128/AAC.48.10.3670-3676.2004
Ren Z, Zheng X, Yang H, Zhang Q, Liu X, Zhang X, Yang S, Xu F, Yang J (2020) Human umbilical-cord mesenchymal stem cells inhibit bacterial growth and alleviate antibiotic resistance in neonatal imipenem-resistant Pseudomonas aeruginosa infection. Innate Immun 26(3):215–221. https://doi.org/10.1177/1753425919883932
Rolain J-M (2013) Food and human gut as reservoirs of transferable antibiotic resistance encoding genes. Front Microbiol 4:173. https://doi.org/10.3389/fmicb.2013.00173
Ronda C, Chen SP, Cabral V, Yaung SJ, Wang HH (2019) Metagenomic engineering of the mammalian gut microbiome in situ. Nat Methods 16(2):167–170. https://doi.org/10.1038/s41592-018-0301-y
Ruppé E, Ghozlane A, Tap J, Pons N, Alvarez A-S, Maziers N, Cuesta T, Hernando-Amado S, Clares I, Martínez JL (2019) Prediction of the intestinal resistome by a three-dimensional structure-based method. Nat Microbiol 4(1):112–123. https://doi.org/10.1038/s41564-018-0292-6
Saeki EK, Kobayashi RKT, Nakazato G (2020) Quorum sensing system: Target to control the spread of bacterial infections. Microb Pathog 142:104068. https://doi.org/10.1016/j.micpath.2020.104068
Saraiva MMS, Silva NMV, Ferreira VA, Moreira Filho ALB, Givisiez PEN, Freitas Neto OC, Berchieri Júnior A, Gebreyes WA, de Oliveira CJB (2022) Residual concentrations of antimicrobial growth promoters in poultry litter favour plasmid conjugation among Escherichia coli Lett Appl Microbiol. https://doi.org/10.1111/lam.13671
Saylor C, Dadachova E, Casadevall A (2009) Monoclonal antibody-based therapies for microbial diseases. Vaccine 27:G38–G46. https://doi.org/10.1016/j.vaccine.2009.09.105
Shabbir MAB, Shabbir MZ, Wu Q, Mahmood S, Sajid A, Maan MK, Ahmed S, Naveed U, Hao H, Yuan Z (2019) CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens. Ann Clin Microbiol Antimicrob 18(1):1–9. https://doi.org/10.1186/s12941-019-0317-x
Sheikh BA, Bhat BA, Alshehri B, Mir RA, Mir WR, Parry ZA, Mir MA (2021) Nano-Drug Delivery Systems: Possible End to the Rising Threats of Tuberculosis. J Biomed Nanotechnol 17(12):2298–2318. https://doi.org/10.1166/jbn.2021.3201
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, Mir MA (2020) Development of new therapeutics to meet the current challenge of drug resistant tuberculosis. Curr Pharm Biotechnol
Sheikh BA, Bhat BA, Ahmad Z, Mir MA (2022) Metabolite fingerprinting of phytoconstituents from Fritillaria cirrhosa D. Don and molecular docking analysis of bioactive peonidin with microbial drug target proteins. Sci Rep 12(1):1–15
Sommer MOA, Dantas G, Church GM (2009) Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325(5944):1128–1131. https://doi.org/10.1126/science.1176950
Sommer MO, Munck C, Toft-Kehler RV, Andersson DI (2017) Prediction of antibiotic resistance: time for a new preclinical paradigm? Nat Rev Microbiol 15(11):689–696. https://doi.org/10.1038/nrmicro.2017.75
Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony R (2016) Compounds that select against the tetracycline-resistance efflux pump. Nat Chem Biol 12(11):902–904. https://doi.org/10.1038/nchembio.2176
Tenover FC (2006) Mechanisms of antimicrobial resistance in bacteria. Am J Med 119(6):S3–S10. https://doi.org/10.1016/j.amjmed.2006.03.011
Tooke CL, Hinchliffe P, Bragginton EC, Colenso CK, Hirvonen VHA, Takebayashi Y, Spencer J (2019) β-Lactamases and β-Lactamase Inhibitors in the 21st Century. J Mol Biol 431(18):3472–3500. https://doi.org/10.1016/j.jmb.2019.04.002
Tyers M, Wright GD (2019) Drug combinations: a strategy to extend the life of antibiotics in the 21st century. Nat Rev Microbiol 17(3):141–155. https://doi.org/10.1038/s41579-018-0141-x
Van Duijkeren E, Schink A-K, Roberts MC, Wang Y, Schwarz S (2018) Mechanisms of bacterial resistance to antimicrobial agents. Microbiol Spect 6(2):6–2. https://doi.org/10.1128/microbiolspec.ARBA-0019-2017
Velez R, Sloand E (2016) Combating antibiotic resistance, mitigating future threats and ongoing initiatives. J Clin Nurs 25:1886–1889. https://doi.org/10.1111/jocn.13246
Von Wintersdorff CJ, Penders J, Van Niekerk JM, Mills ND, Majumder S, Van Alphen LB, Savelkoul PH, Wolffs PF (2016) Dissemination of antimicrobial resistance in microbial ecosystems through horizontal gene transfer. Front Microbiol 7:173. https://doi.org/10.3389/fmicb.2016.00173
Wahid R, Fresnay S, Levine MM, Sztein MB (2016) Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a. Clin Immunol 173:87–95. https://doi.org/10.1016/j.clim.2016.09.006
Walvekar P, Gannimani R, Govender T (2019) Combination drug therapy via nanocarriers against infectious diseases. Eur J Pharm Sci 127:121–141. https://doi.org/10.1016/j.ejps.2018.10.017
Weber D, Cottini SR, Locher P, Wenger U, Stehberger PA, Fasshauer M, Schuepbach RA, Béchir M (2013) Association of intraoperative transfusion of blood products with mortality in lung transplant recipients. Perioperat Med 2(1):1–5. https://doi.org/10.1186/2047-0525-2-20
Wright GD (2016) Antibiotic adjuvants: rescuing antibiotics from resistance. Trends Microbiol 24(11):862–871. https://doi.org/10.1016/j.tim.2016.06.009
Yosef I, Manor M, Kiro R, Qimron U (2015) Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria. Proc Natl Acad Sci 112(23):7267–7272. https://doi.org/10.1073/pnas.1500107112
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The study was financially supported by grants to MAM by the Science and Engineering Research Board, Department of Science and Technology (SERB-DST) Govt. of India, New Delhi, vide Project Grant No: TAR/001213/2018.
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Conceptualization and Design — Dr. Manzoor A Mir and Bashir A Sheikh. Writing — Bashir A Sheikh, Basharat A Bhat. Preparation of figures and tables — Bashir A Sheikh, Basharat A Bhat. Editing Manuscript — Manzoor A Mir. Funding acquisition — Dr. Manzoor A Mir.
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Sheikh, B.A., Bhat, B.A. & Mir, M.A. Antimicrobial resistance: new insights and therapeutic implications. Appl Microbiol Biotechnol 106, 6427–6440 (2022). https://doi.org/10.1007/s00253-022-12175-8
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DOI: https://doi.org/10.1007/s00253-022-12175-8