Collection
Long non-coding RNAs
Emerging evidence indicates that long non-coding RNAs (lncRNAs) – a highly diverse class of transcripts that do not encode proteins – can perform crucial biological roles. While lncRNAs were initially dismissed as “transcriptional noise,” it is now becoming clear that they can carry out a wide array of molecular functions, including regulating neighboring genes in cis and/or affecting downstream targets in trans. However, large-scale human genomic studies have primarily focused on protein-coding regions of the genome, and the potential contributions of lncRNAs to human genetic disorders remain largely unexplored. Thus, this collection brings together articles that detail our current understanding of lncRNAs and highlight important future directions for this rapidly-evolving field.
Editors
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Dr. Rebecca E. Andersen
Division of Genetics and Genomics, Boston Children’s Hospital
Dr. Andersen is a postdoctoral research fellow in the laboratory of Dr. Christopher Walsh at Boston Children’s Hospital. She received her PhD in Developmental and Stem Cell Biology from the University of California, San Francisco. Her primary research focus involves identifying long non-coding RNAs (lncRNAs) that regulate brain development and determining how the disruption of these lncRNAs can play a role in neurodevelopmental conditions such as autism spectrum disorder.
Articles (9 in this collection)
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Integrative regulation of hLMR1 by dietary and genetic factors in nonalcoholic fatty liver disease and hyperlipidemia
Authors (first, second and last of 4)
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Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis
Authors
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N6-methyladenosine modified lncRNAs signature for stratification of biochemical recurrence in prostate cancer
Authors (first, second and last of 14)
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Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets
Authors (first, second and last of 4)
