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Biomaterial-Based Delivery Systems for Chemotherapeutics

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Targeted Cancer Therapy in Biomedical Engineering

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

The fields of understanding the molecular basis, cell genetics, biochemical sciences, materials sciences, and technology all have significant contributions to make towards the research and fabrication of biomaterials. These materials have undergone modification in order to have interaction with biological systems in a therapeutic or diagnostic manner. In the environment where they are placed, they have a synergistic effect. Although it is a centuries-old science, it is currently evolving as a cutting-edge research platform with applications in a wide range of medical sectors, with cancer being the most intensively explored. The overview of these biomaterials-related studies, which covers the application of biomaterials as therapeutics such as immunisations and surface modulators to increase the activity of antigen-specific T cells in immunotherapy for malignancies, is included in the study. In cases of recurrent cancers, tumours that are inadequately immunogenic and tumours that are immunologically resistant, the application has been demonstrated to be reliable. Biomaterials have been used to treat skin cancer and triple-negative breast cancer successfully. Patients with malignancies that lack immunogenicity respond poorly to immunotherapy treatments clinically. When taken at high concentrations, several treatments also have a chance of causing systemic toxicity, and the possibility of autoimmunity is practically always present. In order to address the drawbacks of immunotherapies, biomaterials can be used as cancer detection tools, delivery vehicles to change the pharmacokinetic properties, oral bioavailability, and regulate discharge of therapeutic drugs targeting the immune system, vaccines, and targeted nanoparticle drug delivery systems (active/passive targeting). We will examine the applications of natural, synthetic, and latest design biomaterials in cancer research in this chapter of the book.

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Abbreviations

AC:

Adamantane carboxylic acid

ACT:

Adoptive cell therapy

ALT:

Alanine aminotransferase

AMT:

Absorption mediated transcytosis

APC:

Antigen presenting cells

ApoA1:

Apolipoprotein A1

ASGPR:

Asialoglycoprotein receptor

AST:

Aspartate aminotransferase

AuNP:

Gold nanoparticles

BBB:

Blood brain barrier

BC:

Bacterial cellulose

C–Co–NPs:

Cobalt nanoparticles coated with graphitic shells

–CD:

Beta-cyclodextrin

CDPs:

Cyclic dipeptides

CDT:

Chemo dynamic therapy

CNS:

Central nervous system

CpG:

5′-C-phosphate-G-3

CTX:

Cabazitaxel

Cur:

Curcumin

DEB:

Drug eluting beads

DNA:

Deoxyribonucleic acid

DOX:

Doxorubicin

EGFR:

Epidermal growth factor receptor

FF:

Diphenylalanine

FIONs:

Ferrimagnetic iron oxide nanocubes

GBM:

Glioblastoma

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

HAV:

His-Ala-Val

HCC:

Hepatocellular cancer

HDL:

High density lipoprotein

HFIP:

Hexafluoroisopropanol

HIV:

Human immunodeficiency virus

IAP:

Inhibitor of apoptosis

ICG:

Indocyanine green

ICMVs:

Inter bilayer-crosslinked multilamellar vesicles

IL:

6 Interleukin 6

IONPs:

Iron oxide nanoparticles

LDDSs:

Local drug delivery systems

Lf:

Lactoferrin

LFC:

Lipid formulation classification

MAbs:

Monoclonal antibodies

MC-38:

Murine colon adenocarcinoma cells

MCTs:

Multicellular tumour spheroids

MDA-MB231:

M.D. Anderson—Metastatic Breast 231

MDR:

Multidrug resistance

MNP:

Magnetic nanoparticles

NapFF:

Naphthalene-diphenylalanine

NC:

Nanocrystal

NCA:

N Carboxyanhydride

NDI:

Naphthalene diimide

NHS:

N hydroxy succinimide

NIR:

Near Infrared

NPs:

Nanoparticles

OLISA:

Organelle co-localization-induced supramolecular self-assembly

OvCa:

Ovarian cancer

PBS:

Phosphate buffered saline

PDI:

Perylene diimide

PDT:

Photodynamic therapy

PEI:

Polyethylene imine

pRNA:

Package RNA

PTT:

Photothermal therapy

PTX:

Paclitaxel

PVA:

Poly vinyl alcohol

QDs:

Quantum dots

RF:

Radiofrequency

RNA:

Ribonucleic acid

ROS:

Reactive oxygen species

SDT:

Sonodynamic therapy

siRNA:

Small interfering RNA

SLN:

Solid liquid Nanoparticles

SOD:

Superoxide dismutase

SWNTs’:

Single walled nanotubes

TCA:

Tricarboxylic acid

TME:

Tumor microenvironment

TNF:

Tumor necrosis factor

TRAIL:

Tumour necrosis factor-related apoptosis inducing ligand

WC:

Watson-Crick

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Authors and Affiliations

  1. GOVT of NCT of Delhi, DIPSAR, Delhi Pharmaceutical Sciences and Research University (DPSRU), M.B. Road, PuspVihar, Sector-3, New Delhi, 110017, India

    Dalapathi Gugulothu, Dimple Dhawan, Alisha Sachdeva,  Deepali & Meenakshi Kanwar Chauhan

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  1. Dalapathi Gugulothu
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  2. Dimple Dhawan
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  3. Alisha Sachdeva
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  4. Deepali
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  5. Meenakshi Kanwar Chauhan
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Correspondence to Dalapathi Gugulothu or Meenakshi Kanwar Chauhan .

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  1. Department of Pharmacy, School of Medical and Allied Science, Galgotias University, Greater Noida, India

    Rishabha Malviya

  2. Department of Pharmacy, School of Medical and Allied Science, Galgotias University, Greater Noida,, India

    Sonali Sundram

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Gugulothu, D., Dhawan, D., Sachdeva, A., Deepali, Chauhan, M.K. (2023). Biomaterial-Based Delivery Systems for Chemotherapeutics. In: Malviya, R., Sundram, S. (eds) Targeted Cancer Therapy in Biomedical Engineering. Biological and Medical Physics, Biomedical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-19-9786-0_4

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