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Pancreatic Lipase (PL) Inhibitors from Medicinal Plants and Their Potential Applications in the Management of Obesity

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Natural Products as Enzyme Inhibitors

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Abstract

Obesity is increasingly recognized as a global issue, and its prevalence is rising at an alarming rate around the globe. Obese people are more likely to develop a variety of metabolic illnesses, and metabolic syndrome is frequently related to obesity. Obesity is more common as lipid homeostasis becomes disrupted as a result of genetic, environmental, and lifestyle factors. One of the investigated targets for the treatment of obesity is pancreatic lipase (PL) suppression. Orlistat is the only clinically approved drug as a lipase inhibitor and is currently available for long-term obesity treatment. However, various side effects are associated with the long-term usage of Orlistat in obesity management. Hence, it is important to find comparatively safe and effective treatment methods for obesity. Due to the high structural diversity and wide range of biological activities, natural products are the major area of focus for researchers to find new and safe PL inhibitors from natural sources. The present chapter discusses the PL inhibitory activity of different phytoconstituents of medicinal plants and highlights their PL inhibitory potential.

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Authors and Affiliations

  1. Department of Microbiology and Biotechnology, R. C. Patel Arts, Commerce and Science College, Shirpur, India

    Samadhan Patil, Mohini Patil & Ravindra H. Patil

  2. School of Life Sciences, KBC North Maharashtra University, Jalgaon, Maharashtra, India

    Vijay L. Maheshwari

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  1. Samadhan Patil
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  2. Mohini Patil
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  3. Vijay L. Maheshwari
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  4. Ravindra H. Patil
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Editors and Affiliations

  1. School of Life Sciences, KBC North Maharashtra University, Jalagon, Maharashtra, India

    Vijay L. Maheshwari

  2. Department of Microbiology and Biotechnology, R. C. Patel Arts, Commerce and Science College, Shirpur, India

    Ravindra H. Patil

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Patil, S., Patil, M., Maheshwari, V.L., Patil, R.H. (2022). Pancreatic Lipase (PL) Inhibitors from Medicinal Plants and Their Potential Applications in the Management of Obesity. In: Maheshwari, V.L., Patil, R.H. (eds) Natural Products as Enzyme Inhibitors. Springer, Singapore. https://doi.org/10.1007/978-981-19-0932-0_7

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