Abstract
The mRNA transcripts of voltage-gated calcium channels (VGCCs) are subjected to extensive alternative splicing giving rise to a plethora of channel variants with potentially altered biophysical properties to affect physiological functions. Notably, the discovery of A-to-I RNA editing within the IQ domain of Cav1.3 channel further expands on the post-transcriptional modification processes of VGCCs. Here, we highlight the functional influence alternative splicing and RNA editing has on fine-tuning the activity of High Voltage-Activated (HVA) calcium channels. We will discuss the limitations of employing heterologous expression systems and feature the extensive use of transgenic mouse models in the field, and suggest certain novel approaches that can be applied to further address the physiological consequences of these post-transcriptional modifications of HVA calcium channels.
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Huang, H., Hu, Z., Yeow, S.Q.Z., Soong, T.W. (2022). Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels. In: Zamponi, G.W., Weiss, N. (eds) Voltage-Gated Calcium Channels . Springer, Cham. https://doi.org/10.1007/978-3-031-08881-0_3
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