Qualitative Features of Delay Differential Equations

  • Chapter
  • First Online:
Delay Differential Equations and Applications to Biology

Part of the book series: Forum for Interdisciplinary Mathematics ((FFIM))

  • 1488 Accesses

Abstract

Ordinary and partial differential equations have long played an important role in bioscience, and they are considered to continue to serve as indispensable tools in future investigations as well. However, they frequently provide only a first approximation of the systems under consideration. More realistic models need to include some of the past states of these systems as well; that is, a real system needs to be modeled using differential equations with time-delays (or time-lags). Delay models formulated in mathematical biology include several types of functional differential equations, such as delay differential equations (DDEs), neutral delay differential equations (NDDEs), integro-differential equations, and retarded partial differential equations (RPDEs). Recently, stochastic delay differential equations (SDDEs) have attracted significant attention from researchers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (Canada)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (Canada)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (Canada)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (Canada)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    There are multiple variations of these equations, including forms with differing limits of integration.

References

  1. Balasubramaniam, P., Prakash, M., Rihan, F.A., Lakshmanan, S.: Hopf bifurcation and stability of periodic solutions for delay differential model of HIV infection of CD4 \(^+\) T-cells. Abstr. Appl. Anal. no. ID 982978, 1–18 (2014)

    Google Scholar 

  2. Bocharov, G.A., Rihan, F.A.: Numerical modelling in biosciences using delay differential equations. J. Comput. Appl. Math. 125, 183–199 (2000)

    Article  MathSciNet  Google Scholar 

  3. Metz, J.A.J., Diekmann, O.: The Dynamics of Physiologically Structured Populations. Lecture Notes in Biomathematics, vol. 68. Springer, NY (1986)

    Google Scholar 

  4. Rihan, F.A.: Numerical treatment of delay differential equations in bioscience. PhD. Thesis, University of Manchester, UK (2000)

    Google Scholar 

  5. Rihan, F.A., Abdelrahman, D., Al-Maskari, F., Ibrahim, F.: A delay differential model for tumour-immune response and control with chemo-immunotherapy. Comput. Math. Methods Med. 2014, 15 (2014)

    Article  Google Scholar 

  6. Rihan, F.A., Abdelrahman, D.H., Lakshmanan, S.: A time delay model of tumour- immune system interactions: global dynamics, parameter estimation, sensitivity analysis. Appl. Math. Comput. 232, 606–623 (2014)

    MathSciNet  MATH  Google Scholar 

  7. Rihan, F.A., Azamov, A.A., AlSakaji, H.J.: An inverse problem for delay differential equations: parameter estimation, nonlinearity, sensitivity. Appl. Math. Inform. Sci. 12(1), 63–74 (2018)

    Article  MathSciNet  Google Scholar 

  8. Rihan, F.A., Lakshmanan, S., Maurer, H.: Optimal control of tumour-immune model with time-delay and immuno-chemotherapy. Appl. Math. Comput. 353(7), 147–165 (2019)

    MathSciNet  MATH  Google Scholar 

  9. Rihan, F.A., Rihan, B.F.: Numerical modelling of biological systems with memory using delay differential equations. Appl. Math. Inf. Sci. 9(3), 1615–1658 (2015)

    MathSciNet  Google Scholar 

  10. Rihan, F.A., Kuang, Y., Bocharov, G.: Delay differential equations: Theory, applications and new trends. Editorial: Discrete and Continuous Dynamical Systems - Series S, vol. 13 (2018)

    Google Scholar 

  11. Rihan, F.A., Tunc, C., Saker, S.H., Lakshmanan, S., Rakkiyappan, R.: Applications of delay differential equations in biological systems. Editorial: Complexity, vol. 2018 (2018)

    Google Scholar 

  12. Cooke, K., Grossman, Z.: Discrete delays, distributed delays and stability switches. J. Math. Anal. Appl. 86, 592–624 (1982)

    Article  MathSciNet  Google Scholar 

  13. Mackey, M.C., Glass, L.: Oscillations and chaos in physiological control systems. Science 197, 287–289 (1977)

    Article  Google Scholar 

  14. Mackey, M.C., Milton, J.C.: Feedback, delays, and the origin of blood cell dynamics. Comm. Theor. Biol. 1, 299–327 (1990)

    Google Scholar 

  15. Smith, H.L., Waltman, P.: The theory of the chemostat. Cambridge University Press, Cambridge (1994)

    MATH  Google Scholar 

  16. Bertta, E., Bischi, G., Solimano, F.: Stability in chemostat equations with delayed nutrient recycling. J. Math. Biol. 28, 99–111 (1990)

    MathSciNet  MATH  Google Scholar 

  17. Caperon, R.P.: Time lag in population growth response of isochrysis galbana to variable nitrate environment. Ecology 50, 188–192 (1969)

    Article  Google Scholar 

  18. MacDonald, N.: Biological delay system: Linear stability theory. Cambridge University Press, Cambridge (1989)

    MATH  Google Scholar 

  19. Lorenz, E.N.: Deterministic non-periodic flow. J. Atmos. Sci. 20, 130–141

    Google Scholar 

  20. May, R.: Stability and Complexity in Model Ecosystems. Princeton University Press, Princeton, New Jersey (1974)

    Google Scholar 

  21. Bellman, R., Cooke, K.L.: Differential-Difference Equations. Academic Press, New York (1963)

    MATH  Google Scholar 

  22. Elsgolt’s, L.E., Norkin, S.B.: Introduction to the theory and application of differential equations with deviating arguments

    Google Scholar 

  23. Kolmanovskii, V.B., Myshkis, A.: Applied Theory of Functional Differential Equations (1992)

    Google Scholar 

  24. Kolmanovskii, V.B., Nosov, V.R.: Stability of Functional Differential Equations. Academic Press, NY (1986)

    Google Scholar 

  25. Hale, J.: Theory of Functional Differential Equations. Springer, New York (1997)

    Google Scholar 

  26. Hale, J.K., Verduyn Lunel, S.M.: Introduction to Functional Differential Equations. Springer, NY (1993)

    Book  Google Scholar 

  27. Diekmann, O., van Gils, S., Verduyn Lunel, S., Walter, H.-O.: Delay Equation, Functional-, Complex-, and Nonlinear Analysis. Springer, Berlin (1995)

    MATH  Google Scholar 

  28. Kuang, Y.: Delay Differential Equations with Applications in Population Dynamics. Academic Press (1993)

    Google Scholar 

  29. Banks, R.B.: Growth and Diffusion Phenomena. Mathematical Frameworks and Applications. Texts in Applied Mathematics, vol. 14. Springer, Berlin (1994)

    MATH  Google Scholar 

  30. Gopalsamy, K.: Stability and Oscillations in Delay Differential Equations of Population Dynamics. Kluwer, Dordrecht (1992)

    Book  Google Scholar 

  31. Györi, I., Ladas, G.: Oscillation Theory of Delay Equations with Applications. Oxford Mathematical Monographs. Clarendon Press, Oxford

    Google Scholar 

  32. Cushing, J.M.: Integro-Differential Equations and Delay Models in Population Dynamics. Lecture Notes in Biomathematics. Springer, Berlin (1977)

    Google Scholar 

  33. Driver, R.D.: Ordinary and Delay Differential Equations. Applied Mathematics Series 20. Springer (1977)

    Google Scholar 

  34. Halanay, A.: Differential Equations, Stability, Oscillations, Time Lags. Academic Press, New York (1966)

    MATH  Google Scholar 

  35. MacDonald, N.: Time-Lags in Biological Models. Lecture Notes in Biomathematics, vol. 27. Springer, Berlin (1978)

    Google Scholar 

  36. Waltman, P.: Deterministic Threshold Models in the Theory of Epidemics. Lecture Notes in Biomathematics, vol. 1. Springer, Berlin (1974)

    Google Scholar 

  37. Hutchinson, G.E.: Circular casual systems in ecology. Anal. New York Acad. Sci. 50, 221–246 (1948)

    Google Scholar 

  38. Fowler, A.C.: An asymptotic analysis of the delayed logistic equation when the delay is large. IMA J. Appl. Math. 28(1), 41–47

    Google Scholar 

  39. Jones, G.S.: The existence of periodic solutions of \(f^{\prime } (x)=- \alpha f(x--1)\{1+f(x)\}\). J. Math. Anal. Appl. 5, 435–450 (1962)

    Google Scholar 

  40. Morris, H.C.: A perturbative approach to periodic solutions of delay-differential equations. J. Inst. Math. Applics. 18, 15–24 (1976)

    Article  MathSciNet  Google Scholar 

  41. Volterra, V.: Variations and fluctuations in the numbers of co-existing animal species. In: Scudo, F.M., Ziegler, J.R. (eds.) The Golden Age of Theoretical Ecology: 1923–1940. Lecture Notes in Biomathematics, vol. 22. Springer, Berlin (1979)

    Google Scholar 

  42. Barwell, V.K.: Special stability problems for functional equations 130–135 (1975)

    Google Scholar 

  43. Bellen, A., Jaciewicz, Z., Zennaro, M.: Stability analysis of one-step methods for neutral delay-differential equations. Numer. Math. 52, 605–619 (1988)

    Article  MathSciNet  Google Scholar 

  44. Torelli, L.: Stability of numerical methods for delay differential equations. J. Comput. Appl. Math. 25, 15–26 (1989)

    Article  MathSciNet  Google Scholar 

  45. Krasovskii, N.: Stability of Motion. Stanford University Press (1959)

    Google Scholar 

  46. Lyapunov, A.M.: The general problem of the stability of motion. Int. J. Control 55(3), 531–534 (1992)

    Article  MathSciNet  Google Scholar 

  47. Razumikhin, B.: On the stability of systems with a delay. Prikl. Math. Mech. (in Russian) 20

    Google Scholar 

  48. Boyd, S., El Ghaoui, L., Feron, E., Balakrishnan, V.: Linear matrix inequality in systems and control theory, vol. 15. SIAM, Studies in Applied Mathematics, Philadelphia (1994)

    Google Scholar 

  49. Gu, K., Kharitonov, V., Chen, J.: Stability of Time-delay Systems. Birkhauser Boston, USA (2003)

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fathalla A. Rihan .

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Rihan, F.A. (2021). Qualitative Features of Delay Differential Equations. In: Delay Differential Equations and Applications to Biology. Forum for Interdisciplinary Mathematics. Springer, Singapore. https://doi.org/10.1007/978-981-16-0626-7_1

Download citation

Publish with us

Policies and ethics

Navigation