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Role of SNP in CRP and Biology of Cancer

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Clinical Significance of C-reactive Protein

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Abstract

C-reactive protein (CRP) has gained significant traction in the medical world due to the discovery of its role in identifying and categorizing cancer. Researchers have worked with CRP in reference to detecting cardiovascular disease and inflammatory infections in the past, and this expansion into cancer has shown that CRPs often play a significant role in the risk, prognosis, and diagnosis of cancer. Single nucleotide polymorphisms (SNPs) in these CRPs have also been seen to have an active role in tumorogenesis and studying certain SNPs has shown increased or decreased risk for certain types of cancer. This chapter includes different SNPs of CRPs and their relationship to diseases ranging from coronary heart disease to breast cancer. While the data for certain SNPs from different experiments can conflict to whether or not it increases the risk of tumorigenesis, it also has shown consistent results for other cases. This method of analysis helps us build a foundation for a novel type of cancer diagnosis, one that can even predict the chance of certain diseases in an individual long before the symptoms may start to manifest.

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Abbreviations

AD:

Alzheimer’s disease

AMRD:

Age-related macular degeneration

APP:

Acute phase protein

C/EBP:

CCAAT-enhancer-binding protein

CRP:

C-reactive protein

CVD:

Cardiovascular disease

hs-CRP:

High-sensitivity CRP

IL:

Interleukin

LDL:

Low-density lipoprotein

mCRP:

Monomeric C-reactive

NF-kB :

Nuclear factor kappa

NO:

Nitric oxide

pCRP:

Pentametric isoform

PD:

Parkinson’s disease

PRR:

Pattern recognition receptor

S. pneumoniae :

Streptococcus pneumoniae

SAP:

Serum amyloid P-competent

SLE :

Systemic lupus erythematosus

SNP:

Single nucleotide polymorphism

STAT3 :

Signal transducer and activator of transcription 3

T2D:

Type 2 diabetes

TNF:

Tumor necrosis factor

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Authors and Affiliations

  1. University of Illinois Urbana Champaign, Urbana, IL, USA

    Rishav Dasgupta

  2. School of Biological Sciences, NISER, Bhubaneswar, Orissa, India

    Shyamasree Ghosh

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  1. Rishav Dasgupta
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Editors and Affiliations

  1. Department of Zoology, Behala College, Kolkata, West Bengal, India

    Waliza Ansar

  2. School of Biological Sciences, NISER Bhubaneswar, India, Orissa, India

    Shyamasree Ghosh

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Dasgupta, R., Ghosh, S. (2020). Role of SNP in CRP and Biology of Cancer. In: Ansar, W., Ghosh, S. (eds) Clinical Significance of C-reactive Protein. Springer, Singapore. https://doi.org/10.1007/978-981-15-6787-2_6

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