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Association of − 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population

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Abstract

Objective

CRP gene polymorphism is common in inflammatory diseases, but such association has not been reported in periodontitis. Our objective was to interrogate SNPs of crp in chronic periodontitis in a case–control manner.

Methods

DNAs were extracted from mouthwash samples of 116 volunteers using salting-out method. Selected 12 5′UTR SNPs of crp were genotyped using ARMS–PCR.

Results

TC genotype of − 757T > C polymorphism (rs3093059) showed protective association (OR— 0.29, 95%CI—0.12–0.68, and p—0.004), and wild type − 757TT showed susceptible association with a p value of 0.008 (OR—3.09, 95%CI—1.33–7.15).

Conclusion

The observation of protective and susceptible association of crp − 757T > C polymorphism may be useful for better management and prophylaxis of periodontitis.

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Acknowledgements

The authors acknowledge support from DBT-BUILDER programme (Ref.: BT/PR12153/INF/22/200/2014), Government of India.

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Authors and Affiliations

  1. Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India

    Sreekanth M. Selvaraj, Sinthuja Gurumoorthy & Adaikkalam Vellaichamy

  2. Department of Periodontology and Oral Implantology, Sree Balaji Dental College and Hospital, Chennai, India

    Judith J. Christina & Bagavad Gita Jayaraman

Authors
  1. Sreekanth M. Selvaraj
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  2. Judith J. Christina
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  4. Bagavad Gita Jayaraman
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  5. Adaikkalam Vellaichamy
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Corresponding author

Correspondence to Adaikkalam Vellaichamy.

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The authors declare no conflict of interest.

Ethical approval

Ethical clearance for the study was obtained from the Institutional Ethical Committee of Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, India—600100 (Ethics Committee Registration No: ECR/761/Inst/TN/2015).

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Informed consent was obtained from all individual participants.

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Responsible Editor: John Di Battista.

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Selvaraj, S.M., Christina, J.J., Gurumoorthy, S. et al. Association of − 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population. Inflamm. Res. 68, 347–349 (2019). https://doi.org/10.1007/s00011-019-01230-2

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  • DOI: https://doi.org/10.1007/s00011-019-01230-2

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