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Acute Retinal Necrosis (ARN)

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Albert and Jakobiec's Principles and Practice of Ophthalmology

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Abstract

Initially described in Japan in 1971 by Urayama and colleagues and termed Kirisawa’s uveitis, acute retinal necrosis (ARN) is a sudden onset unilateral or bilateral panuveitis that presents with iritis, vitreous inflammation, retinal periarteritis, optic neuropathy, and confluent peripheral retinal infiltrates [1–8]. The syndrome is now recognized to be predominantly the consequence of acute infection of the retina by alpha class Herpesvirus hominis [9, 10]. Consensus among members of the American Uveitis Society is that the term acute retinal necrosis be applied only to those cases that conform to the clinical syndrome characterized by peripheral retinal necrosis with discrete borders, rapid progression with circumferential spread in untreated eyes, occlusive vasculopathy with arteriolar involvement, and prominent inflammation in the vitreous and anterior chamber. Optic neuropathy or atrophy, scleritis, and pain occur in some patients but are not part of the AUS diagnostic criteria [2, 11].

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Authors and Affiliations

  1. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA

    Janet L. Davis

  2. Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, USA

    Mark S. Blumenkranz

Authors
  1. Janet L. Davis
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  2. Mark S. Blumenkranz
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Correspondence to Janet L. Davis .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Oregon Health & Science University Department of Ophthalmology, Portland, OR, USA

    Daniel Albert

  2. Massachusetts Eye and Ear, Boston, MA, USA

    Joan Miller

  3. Department of Ophthalmology, University of Illinois at Chicago Department of Ophthalmology, Chicago, IL, USA

    Dimitri Azar

  4. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

    Lucy H. Young

Section Editor information

  1. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Lucia Sobrin

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Davis, J.L., Blumenkranz, M.S. (2020). Acute Retinal Necrosis (ARN). In: Albert, D., Miller, J., Azar, D., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-90495-5_7-1

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  • DOI: https://doi.org/10.1007/978-3-319-90495-5_7-1

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  • Print ISBN: 978-3-319-90495-5

  • Online ISBN: 978-3-319-90495-5

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