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Use of Plant Secondary Metabolites as Nutraceuticals for Treatment and Management of Cancer: Approaches and Challenges

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Anticancer plants: Properties and Application

Abstract

Nowadays cancer has become a common and life-threatening disease, claiming millions of lives and adding many more millions of new cases every year globally. Due to increasing incidences of cancer, a new trend is emerging globally due to accessibility of information on the internet; a lot of cancer patients’ claimed to be “cancer survivor” by use of dietary supplements or nutraceuticals. Nutraceuticals are rich source of nutrients or part of a food that has a medical or health benefit, including the prevention and treatment of diseases. In this chapter, we will discuss the most important nutraceuticals as a source of anticancer agents, such as green tea, chili, pepper, saffron, turmeric, soy, black pepper, fenugreek, cloves, and ginger. These agents are the source of phytomolecules, such as curcumin, crocin, crocetin, capsaicin, diosgenin, isoflavones, resveratrol, epigallocatechin gallate, piperine, eugenol, and gingerol. It has been reported that these phytomolecules are able to prevent, reverse, or delay the carcinogenic process. Over the decades, attention over these nutraceuticals has been increased due to their promising effects on tumor cells. These nutraceuticals exhibit anticancer properties by induction of apoptosis, DNA damage, causing G2/M arrest, inhibition of proliferation, migration and invasion of cancer cells, and sensitizing cancer cells to chemotherapy and radiotherapy. The aim of this chapter is to focus on the sources of nutraceutical compounds and their importance in the management of cancer. Moreover, the mechanism of action is also highlighted.

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The author declares that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia

    Zahid H. Siddiqui, Zahid K. Abbas & Mohammad Nasir Khan

  2. Department of Zoology, Zakir Husain Delhi College, University of Delhi, New Delhi, India

    B. Hareramdas

  3. Division of Bioscience, Institute of Pesticide Formulation Technology, Sector 20, Udyog Vihar, NH-8, Gurgaon 122016, Haryana, India

    Talat Parween

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  1. Zahid H. Siddiqui
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  3. Zahid K. Abbas
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  4. Talat Parween
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  5. Mohammad Nasir Khan
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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Siddiqui, Z.H., Hareramdas, B., Abbas, Z.K., Parween, T., Khan, M.N. (2018). Use of Plant Secondary Metabolites as Nutraceuticals for Treatment and Management of Cancer: Approaches and Challenges. In: Akhtar, M., Swamy, M. (eds) Anticancer plants: Properties and Application. Springer, Singapore. https://doi.org/10.1007/978-981-10-8548-2_17

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