Abstract
Divasidum is a cardiac glycoside compound found in the seeds of Apocynaceae plant Strophanthus divaricatus. In China, divasidum has been developed into injection for the treatment of heart failure. The current clinical application of the divasidum preparation is divasidum injection, which is a mixture of divasidum and divostroside. The cardiotonic action of divasidum is similar to strophanthidin. Another study shows that divasidum has a diuretic effect and sedative effect, and it is similar to strophanthin K.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
“Chinese Flora” (1977 edition);63:152.
Kun S. Pharmacology and clinical application of divasidum. Tian** Medical Journal. 1962;(07): 396-401.
Jiang M, Li Z. Comparison of the effects of divasidum and strophanthin K on the heart failure caused by metabolic inhibitors. Acta Phys Sin. 1958;(04).
Qiu Y, et al. Effects of divaricoside (Div) on [Ca2+] of guinea pig ventricular myocytes in different extra cellular solution. Chin J Pharmacol Toxicol. 2007;21(5):381–4.
Zheng S. The diuretic and sedative action of divasid a gardiac glycoside preparation from Yang. Chio-Ou (Strophanthus divari.catus (Lour.)Hook,et arn.). Acta Pharm Sin. 1959;7(5):161–5.
Karkare S, et al. Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest. J Nat Prod. 2007;70:1766–70.
Li Y et al. A preliminary observation on the clinical efficacy of divasidum preparation in the treatment of 55 cases of heart failure. J Wuhan Med Coll. 1958;(2):117–22.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
About this chapter
Cite this chapter
Hu, K., Du, LD., Lu, Y. (2018). Divasidum. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_11
Download citation
DOI: https://doi.org/10.1007/978-981-10-8022-7_11
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8021-0
Online ISBN: 978-981-10-8022-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)