SpringerLink
Log in

Overview of Modern Research on Danshen

  • Chapter
  • First Online:
Dan Shen (Salvia miltiorrhiza) in Medicine

Abstract

Danshen (Salvia miltiorrhiza) is one of the most widely and earliest used herbal drugs in traditional Chinese medicine. A comprehensive knowledge about its clinical therapeutic effects and indications has been acquired over long-term clinical application. It is also one of the main Chinese herbal drugs that have been studied with modern medical technology. Thanks to the joint efforts of chemists, pharmacologists, and medical researchers we now have almost a thorough knowledge and understanding of Danshen regarding its biological, chemical, and pharmacological properties and clinical therapeutic effects. Besides these fundamental achievements, many clinical preparations with Danshen as the principal active component have been developed, which play an important role in the prevention and treatment of diseases. In this chapter, the current state of research on Danshen is reviewed, in which much data are drawn from the findings in our own laboratory.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 117.69
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 159.99
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
EUR 192.59
Price includes VAT (Germany)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Guo J, et al. Study and clinical application of Danshen. Bei**g: The Medicine Science and Technology Press of China; 1992.

    Google Scholar 

  2. Xu R, et al. Biology and application of Danshen. Bei**g: Science Press; 1990.

    Google Scholar 

  3. Institute of Materia Medica, Chinese Academy of Medical Sciences. Danshen–modern study on Chinese herbal medicine, vol. 2. Bei**g: Combination Press of Bei**g, Medical University and Peking Union Medical College; 1996. p. 472.

    Google Scholar 

  4. Lin H, et al. Chin Pharm J. 1993;45:615.

    CAS  Google Scholar 

  5. Choi JS, Kang HS, Jung HA, et al. Fitoterapia. 2001;72(1):30.

    Article  PubMed  CAS  Google Scholar 

  6. Lin HC, Chang WL. Phytochem. 2000;53(8):951.

    Article  CAS  Google Scholar 

  7. Lin HC, Ding HY, Chang WL. J Nat Prod. 2001;64(5):648.

    Article  PubMed  CAS  Google Scholar 

  8. Ai CB, Li LN. J Nat Prod. 1988;51:145.

    Article  CAS  Google Scholar 

  9. Du G, Zhang J. Basic and Clinical Medicine, 2000, 20(5):394.

    Google Scholar 

  10. Tian G, Zhang Y, Zhang T, et al. J Chromatogr A. 2000;904(1):107.

    Article  PubMed  CAS  Google Scholar 

  11. Pan X, Niu G, Liu H. J Chromatogr A. 2001;922(1–2):37l.

    Google Scholar 

  12. Li HB, Chen F. J Chromatogr A. 2001;925(1–2):109.

    Article  PubMed  CAS  Google Scholar 

  13. Li YC, Zeng JQ, Liu LM, et al. Chromatogr. 2002;20(1):40.

    CAS  Google Scholar 

  14. Zhang QW, Zhang Y, Li JP, et al. China J Chin Materia Medica. 2001;26(12):848.

    CAS  Google Scholar 

  15. Chen B, Zhu M, **ng WX, et al. Acta Pharma Sin. 2001;36(1):55.

    CAS  Google Scholar 

  16. Goren AC, Topcu G, Oksuz S, et al. Nat Prod Lett. 2002;16(1):47.

    Article  PubMed  CAS  Google Scholar 

  17. Lee DS, Lee SH, Noh JG, et al. Biotechnol Biochem. 1999;63(12):2236.

    Article  CAS  Google Scholar 

  18. Maki T, Kawahara Y, Tanonaka K, et al. Planta Med. 2002;68(12):1103.

    Article  PubMed  CAS  Google Scholar 

  19. Takahashi K, Ouyang X, Komatsu K, et al. Biochem Pharmacol. 2002;64(4):745.

    Article  PubMed  CAS  Google Scholar 

  20. Niu XL, Ichimori K, Yang X, et al. Free Radic Res. 2000;33(3):305.

    Article  PubMed  CAS  Google Scholar 

  21. Ko JS, Ryu SY, Kim YS, et al. Arch Pharm Res. 2002;25(4):446.

    Article  PubMed  CAS  Google Scholar 

  22. Park JW, Lee SH, Yang MK, et al. Arch Pharm Res. 2008;31(1):47.

    Article  PubMed  CAS  Google Scholar 

  23. Kang BY, Chung SW, Kim SH, et al. Immunopharmacol. 2000;49(3):355.

    Article  CAS  Google Scholar 

  24. Yagi A, Takeo S. Yakugaku Zasshi. 2003;123(7):517.

    Article  PubMed  CAS  Google Scholar 

  25. Kim SY, Moon TC, Chang HW, et al. Phytother Res. 2002;16(7):616.

    Article  PubMed  CAS  Google Scholar 

  26. Ryu SY, Oak MH, Kim KM. Planta Med. 1999;65(7):654.

    Article  PubMed  CAS  Google Scholar 

  27. Sung HJ, Choi SM, Yoon Y, et al. Exp Mol Med. 1999;31(4):174.

    Article  PubMed  CAS  Google Scholar 

  28. Yoon Y, Kim YO, Jeon WK, et al. J Ethnopharmacol. 1999.;68(1–3):121.

    Google Scholar 

  29. Kim JY, Kim KM, Nan JX, et al. Pharmacol Toxicol. 2003;92(4):195.

    Article  PubMed  CAS  Google Scholar 

  30. Wang YL, et al. Chin J Pharmacol Toxicol. 1994;8:19.

    CAS  Google Scholar 

  31. Lam BY, Lo AC, Sun X, et al. Phytomedicine. 2003;10(4):286.

    Article  PubMed  CAS  Google Scholar 

  32. Ueng YF, Kuo YH, Peng HC, et al. Xenobiotica. 2003;33(6):603.

    Article  PubMed  CAS  Google Scholar 

  33. Sun X, et al. Chin Tradit Herbal Med. 1991;22:20.

    CAS  Google Scholar 

  34. Zhang X, et al. Chin J Pharmacol Toxicol. 1991;5:27.

    CAS  Google Scholar 

  35. Petersen M, Simmonds MS. Phytochem. 2003;62(2):121.

    Article  CAS  Google Scholar 

  36. Huang DS, Zhang JT. Acta Pharm Sin. 1992;27:96.

    CAS  Google Scholar 

  37. Du GH, et al. Chin J Pathophysiol. 1998;14(7):862.

    Google Scholar 

  38. Xu WG, Xu LN. Acta Pharm Sin. 1994;29:412.

    Google Scholar 

  39. Du GH, et al. Acta Pharm Sin. 1995;30:731.

    CAS  Google Scholar 

  40. Lee GT, Ha H, Jung M, et al. J Am Soc Nephrol. 2003;14(3):709.

    Article  PubMed  CAS  Google Scholar 

  41. Liu YL, Liu GT. Acta Pharm Sin. 2002;37(2):81.

    CAS  Google Scholar 

  42. Durairajan SS, Yuall Q, **e L, et al. Neurochem Int. 2008;52(4–5):741.

    Article  PubMed  CAS  Google Scholar 

  43. Du GH, et al. Chin Med J. 1997;110:65.

    PubMed  CAS  Google Scholar 

  44. Du GH, Qiu Y, Zhang JT. J Asia Nat Prod Res (JANPR). 2000;2:145.

    Article  CAS  Google Scholar 

  45. Tang MK, Ren DC, Zhang JT, et al. Phytomedicine. 2002;9(5):405.

    Article  PubMed  CAS  Google Scholar 

  46. Du GH, et al. Acta Pharma Sin. 1995;30:184.

    CAS  Google Scholar 

  47. Du GH, Zhang JT. Shandong Med J. 1994;34:8.

    Google Scholar 

  48. Ren DC, Du GH, Zhang JT. Chin Pharmacol Bull. 2002;18:275.

    CAS  Google Scholar 

  49. Zhang JT, Du GH, Tang MK, et al. Anti-senile-dementia actions of salvianolic acid B. Symposiums of Annual Conference of Chinese Academy of Medical Sciences and Peking Union Medical College. Press of Peking Union Medical College; 2002, p. 238.

    Google Scholar 

  50. Ren DC, Du GH, Zhang JT. Chin J Pharmacol Toxical. 2003;17(5):333.

    CAS  Google Scholar 

  51. Ren DC, Du GH, Zhang JT. Jpn J Pharmaco. 2002;90:276.

    Article  CAS  Google Scholar 

  52. Ren DC, Du GH, Zhang JT. Chin Med J. 2003;116(4):630.

    PubMed  CAS  Google Scholar 

  53. Yokozawa T, et al. Nippon **zo Gakkai shi. 1993;35:337.

    PubMed  CAS  Google Scholar 

  54. Yokozawa T, et al. Chem Pharm Bull. 1991;39:732.

    Article  PubMed  CAS  Google Scholar 

  55. Liu P, Hu Y, Liu C, et al. Liver. 2001;21(6):384.

    Article  PubMed  CAS  Google Scholar 

  56. Jung M, Lee HC, Ahn CW, et al. Chem Pharm Bull. 2002;50(8):115.

    Article  Google Scholar 

  57. Du GH, et al. Acta Pharma Sin. 1995;30:561.

    CAS  Google Scholar 

  58. Yang XF, Wang NP, Zeng FD. China J Chin Materia Medica. 2002;27(5):325.

    CAS  Google Scholar 

  59. Chan TY. Ann Pharmacother 2001;35(4):501.

    Google Scholar 

  60. **** Q, Peillng H, Yawei L, et al. J Pharm Pharmacol. 2003;55(8):1163.

    Article  PubMed  CAS  Google Scholar 

  61. Qiao LX, et al. Chin Med Pharmacol. 1992;6:40.

    Google Scholar 

  62. Li ZH, et al. Chin J Pathophysiol. 1993;9:17.

    Google Scholar 

  63. Bi HC, Zuo Z, Chen X, et al. Xenobiotica. 2008;38(2):185.

    Article  PubMed  CAS  Google Scholar 

  64. FugkBerman A. Prev Cardiol. 2000;3(1):24.

    Article  Google Scholar 

  65. Sugiyama A, Zhu BM, Takahara A, et al. Circ J. 2002;66(2):182.

    Article  PubMed  Google Scholar 

  66. Shi X, **a Z, Fang J. Chin J Integr Tradit W Med. 2000;20(12):896.

    Google Scholar 

  67. Wang SP, Zang WJ, Kong SS, et al. Eur J Pharmacol. 2008;579(1–3):283.

    Article  PubMed  CAS  Google Scholar 

  68. Shi W, Fu S, Du N. Chin J Integr Tradit W Med. 2000;20(4):269.

    CAS  Google Scholar 

  69. Zhang WH, Wang JS, Zhou Y, et al. World J Gastroenterol. 2003;9(9):2040.

    PubMed  CAS  Google Scholar 

  70. Ye HG, Song YF, et al. Chin J Digestion. 1991;11:87.

    Google Scholar 

  71. Yu ZF, Jiang JX, et al. J Yunnan Coll Tradit Chin Med. 1992;15:23.

    Google Scholar 

  72. Huang LB, Guisheng X. J of Gannan Med Coll. 1990;10:215.

    Google Scholar 

  73. Yu ZF, et al. J Yunnan Coll Tradit Chin Med. 1991;14:41.

    Google Scholar 

  74. Deng HJ, et al. China J Chin Materia Medica. 1992;17:233.

    CAS  Google Scholar 

  75. Qi XG, et al. Chin J Integr Tradit W Med. 1991;11:102.

    CAS  Google Scholar 

  76. Zeng MD, et al. J Shanghai Second Med University. 1991;11:204.

    Google Scholar 

  77. Lu YS. Hubei J Tradit Chin Med. 1990;4:14.

    Google Scholar 

  78. Zhang BZ, et al. China J Tradit Chin Med Pharm. 1991;6:26.

    Google Scholar 

  79. Yokozawa T, et al. Nephron. 1991;57:78.

    Article  PubMed  CAS  Google Scholar 

  80. Chen FM, et al. Chin J Nephrol. 1989;5:66.

    CAS  Google Scholar 

  81. Zheng SS, et al. J Integr Tradit Chin W Med. 1989;9:158.

    CAS  Google Scholar 

  82. Zheng XK, et al. J Integr Tradit Chin W Med. 1991;11:733.

    CAS  Google Scholar 

  83. Du HW, et al. J Integr Tradit Chin W Med. 1990;10:230.

    CAS  Google Scholar 

  84. YoN Hu. J **an Med University. 1991;12:139.

    Google Scholar 

  85. Fang ZY, I. in R, Yuan BX, et al. Life Sci. 2007;81(17–18):1339–1345.

    Google Scholar 

  86. Fang ZY, Lin R, Yuan BX, et al. J Ethnopharmacol. 2008;115(2):217–222.

    Google Scholar 

  87. Yang WD, et al. Chin Pharmacol Bull. 1990;6:118.

    Google Scholar 

  88. Liu JR, Chen GF, Shih NH, Kuo PC. Phytomedicine. 2008;15(1–2):23–30.

    Article  PubMed  Google Scholar 

  89. Qi SP, et al. Chin Sci Bull. 1989;7:547.

    Google Scholar 

  90. Guo ZX, et al. Chin Tradit Patent Med. 1993;15:27.

    CAS  Google Scholar 

  91. Wang GZ, Ru X, Ding LH, et al. World J Gastroenterol. 1998;4(2):169.

    PubMed  Google Scholar 

  92. Yang X, Lu Y, **e D. Bull Hunan Med University. 1999;24(5):465.

    CAS  Google Scholar 

  93. Zhang LH, Yao CB, Li HQ. World J Gastroenterol. 2001;7(5):672.

    PubMed  CAS  Google Scholar 

  94. Wang XF, Zhao MQ. J First Military Med University. 2003;23(9):969.

    Google Scholar 

  95. Wang F. J Tradit Chin Med. 2002;22(1):3.

    PubMed  Google Scholar 

  96. Yi LQ, Wang XW. C J Integr Tradit W Med. 2002;22(7):543.

    Google Scholar 

  97. Bao HY, Yu HL, Wang L. C J Integr Tradit W Med. 2002;22(1):28.

    Google Scholar 

  98. Yu W, Shen F, Ma Z. C J Integr Tradit W Med. 2000;20(2):94.

    CAS  Google Scholar 

  99. Abd-Elazem IS, Chen HS, Bates RB, et al. Antiviral Res. 2002;55(1):91.

    Article  PubMed  CAS  Google Scholar 

  100. **e XQ, et al. C J Integr Tradit W Med. 1993;13:527.

    Google Scholar 

  101. Yao GH, et al. C J Integr Tradit W Med. 1993;13:369.

    Google Scholar 

  102. Wang XP, Yang RM. Fur Neurol. 2003;50(3):153.

    CAS  Google Scholar 

  103. Cao EH, Liu XQ, Wang JJ, et al. Free Radic Biol Med. 1996;20(6):801.

    Article  PubMed  CAS  Google Scholar 

  104. Chen YH, Du GH, Zhang JT. Acta Pharmacol Sin. 2000;21:463.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Bei**g, China

    Guanhua Du & Juntian Zhang

Authors
  1. Guanhua Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Juntian Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Guanhua Du or Guanhua Du .

Editor information

Editors and Affiliations

  1. Tian**, China

    **jun Yan

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Du, G., Zhang, J. (2015). Overview of Modern Research on Danshen. In: Yan, X. (eds) Dan Shen (Salvia miltiorrhiza) in Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9463-3_1

Download citation

Publish with us

Policies and ethics

Search

Navigation