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Aspects of Nondisjunction

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Mutations in Man

Abstract

Aneuploidy is a significant cause of pregnancy wastage, perinatal death, malformation and mental retardation in man (see Chap. Sperling, p. 128ff.). Much information is available on the incidence of aneuploidy at birth and at various gestational stages after implantation, in addition to the association of several trisomies with maternal age which has been known for many years (Ford 1981; Sankaranarayanan 1982, for review). Many studies with mammals have convincingly shown that physical and chemical factors may cause aneuploidy in exposed germ cells (Hansmann 1983). However, 25 years after the first cytogenetical description of trisomy in man (Léjeune et al. 1959; Jacobs and Baikie 1959; Ford et al. 1959) we can still only speculate as to the mechanisms involved in chromosomal nonsegregation during meiosis.

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Authors and Affiliations

  1. Institut für Humangenetik, Universität Göttingen, Nikolausberger Weg 5a, 3400, Göttingen, Germany

    I. Hansmann

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  1. I. Hansmann
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Editors and Affiliations

  1. Institut für Genetik, Freie Universität Berlin, Arnimallee 5-7, 1000, Berlin 33, Germany

    Günter Obe

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© 1984 Springer-Verlag Berlin Heidelberg

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Hansmann, I. (1984). Aspects of Nondisjunction. In: Obe, G. (eds) Mutations in Man. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69530-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-69530-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69532-2

  • Online ISBN: 978-3-642-69530-8

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