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Microvasculature and Perfusion in Normal Tissues and Tumors

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Thermoradiotherapy and Thermochemotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The tissue temperature during heating is dependent on the influx of energy and efflux of heat, mainly through the convective heat transfer between the tissue and circulating blood. It follows that the temperature in tissues with poor blood circulation will rise higher than that in tissues with good blood circulation. It has been demonstrated that a variance in temperature as small as 0.5°-1.0°C in the therapeutic range, i.e., 42°-45°C, can cause a significant difference in cell killing or tissue damage (Dewey et al. 1977; Fajardo 1984; Field et al. 1977). Indications are that such a small difference in temperature can easily be caused by a small change in blood flow (Jain 1980; Song et al. 1980a-c; Song 1982a,b). It is known that the anatomical characteristics of blood vessels and blood flow in different tissues or tumors are markedly different. Furthermore, the changes in blood vessels and blood flow induced by heat are profoundly different in different tissues or tumors (Dewhirst 1987; Dudar and Jain 1984; Jain and Ward-Hartley 1984;

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  1. Radiation Biology Section, Department of Therapeutic Radiology, University of Minnesota, Box 494 UMHC, Minneapolis, MN, 55455, USA

    C. W. Song PhD, I. B. Choi MD, B. S. Nah MD, S. K. Sahu PhD & J. L. Osborn BS

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  1. C. W. Song PhD
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  2. I. B. Choi MD
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  3. B. S. Nah MD
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  4. S. K. Sahu PhD
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  5. J. L. Osborn BS
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Editors and Affiliations

  1. Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    M. Heinrich Seegenschmiedt

  2. Radiation Oncology Physics Division, Stanford University Medical Center, SUMC Room S-044, Stanford, CA, 94305, USA

    Peter Fessenden PhD (Professor Emeritus, Radiation Oncology) (Professor Emeritus, Radiation Oncology)

  3. Department of Clinical Oncology, Hammersmith Hospital, Ducane Road, London, W12 OHS, UK

    Clare C. Vernon MA, FRCR

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© 1995 Springer-Verlag Berlin Heidelberg

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Song, C.W., Choi, I.B., Nah, B.S., Sahu, S.K., Osborn, J.L. (1995). Microvasculature and Perfusion in Normal Tissues and Tumors. In: Seegenschmiedt, M.H., Fessenden, P., Vernon, C.C. (eds) Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57858-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-57858-8_7

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