Prophylaxen

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Zusammenfassung

Die Pneumonieprophylaxe bei beatmeten Patienten zur Vermeidung einer Ventilator-assoziierten Pneumonie (VAP) ist auf Grund einer deutlich erhöhten Morbidität und Letalität von elementarer Bedeutung. Eine Auswertung der Medical Information Mart for Intensive Care III (MIMIC III) Datenbank ergab nach entsprechender Adjustierung eine Erhöhung des Risikos bzgl. der 90d und 180d Mortalität bei Patienten mit einer VAP gegenüber Patienten ohne eine VAP entsprechend bei dem 1,465fachen (OR = 1,465, 95 % Konfidenz Intervall (KI) 1,188–1,807, p < 0,001) und dem 1,635fachen (OR = 1,635, 95 % KI: 1,333–2,005, p < 0,001) (Luo et al. 2021).

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Literatur

  • Alhazzani W, Lim W, Jaeschke RZ et al (2013a) Heparin thromboprophylaxis in medicalsurgical critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care Med 41(9):2088–2098. http://www.ncbi.nlm.nih.gov/pubmed/23782973

    Article  CAS  Google Scholar 

  • Alhazzani W, Alenezi F, Jaeschke RZ, Moayyedi P, Cook DJ (2013b) Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 41:693–705. https://doi.org/10.1097/CCM.0b013e3182758734

    Article  CAS  Google Scholar 

  • Alhazzani W, Alshamsi F, Belley-Cote E, Heels-Ansdell D, Brignardello-Petersen R, Alquraini M et al (2018) Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials. Intensive care med 44(1):1–11. https://doi.org/10.1007/s00134-017-5005-8

  • Angeloni G, Alberti S, Romagnoli E, Banzato A, Formichi M, Cucchini U, Pengo V (2011) Low molecular weight heparin (parnaparin) for cardioembolic events prevention in patients with atrial fibrillation undergoing elective electrical cardioversion: a prospective cohort study. Intern Emerg med 6(2):117–123. https://doi.org/10.1007/s11739-010-0479-1

  • Almeida Medeiros AB de, Fernandes MIDCD, de Sá Tinôco JD, Cossi MS, de Oliveira Lopes MV, de Carvalho Lira ALB (2018) Predictors of pressure ulcer risk in adult intensive care patients: a retrospective case-control study. Intensive Crit Care Nurs 45:6–10

    Google Scholar 

  • Amaral MC, Favas C, Alves JD, Riso N, Riscado MV (2010) Stress-related mucosal disease: incidence of bleeding and the role of omeprazole in its prophylaxis. Eur J Intern Med 21:386–388. https://doi.org/10.1016/j.ejim.2010.06.010

    Article  Google Scholar 

  • Anstey MH, Litton E, Palmer RN, Neppalli S, Tan BJ, Hawkins DJ, Krishnamurthy RB, Jacques A, Sonawane RV, Chapman AR, Norman R (2019) Clinical and economic benefits of de-escalating stress ulcer prophylaxis therapy in the intensive care unit: a quality improvement study. Anaesth Intensive Care 47:503–509. https://doi.org/10.1177/0310057X19860972

    Article  Google Scholar 

  • Attia J, Ray JG, Cook DJ et al (2001) Deep vein thrombosis and its prevention in critically ill adults. Arch Intern Med 161(10):1268–1279

    Article  CAS  Google Scholar 

  • Banerjee A, Girard TD, Pandharipande P (2011) The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unit. Curr Opin Anaesthesiol 24(2):195–201

    Article  Google Scholar 

  • Barletta JF, El-Ibiary SY, Davis LE, Nguyen B, Raney CR (2013) Proton pump inhibitors and the risk for hospital-acquired Clostridium difficile infection. Mayo Clin Proc 88:1085–1090. https://doi.org/10.1016/j.mayocp.2013.07.004

    Article  CAS  Google Scholar 

  • Bateman BT, Bykov K, Choudhry NK, Schneeweiss S, Gagne JJ, Polinski JM, Franklin JM, Doherty M, Fischer MA, Rassen JA (2013) Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study. BMJ 19:f5416. https://doi.org/10.1136/bmj.f5416

    Article  Google Scholar 

  • Batra P, Soni KD, Mathur P (2020) Efficacy of probiotics in the prevention of VAP in critically ill ICU patients: an updated systematic review and meta-analysis of randomized control trials. J Intensive Care 8:81. https://doi.org/10.1186/s40560-020-00487-8

    Article  Google Scholar 

  • Beusekom I van,, Bakhshi-Raiez F, de Keizer N, Dongelmans D, van der Schaaf M (2016) Reported burden on informal caregivers of ICU survivors: a literature review. Crit Care 20(1):16

    Google Scholar 

  • Borkgren-Okonek MJ, Hart RW, Pantano JE, Rantis PC, Guske PJ, Kane JM et al (2008) Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity. Surg Obes Relat Dis: Official Journal of the American Society for Bariatric Surgery 4(5):625–631. https://doi.org/10.1016/j.soard.2007.11.010

  • Bowton DL, Hite RD, Martin RS, Sherertz R (2013) The impact of hospital-wide use of a tapered-cuff endotracheal tube on the incidence of ventilator-associated pneumonia. Respir Care 58:1582–1587. https://doi.org/10.4187/respcare.02278

    Article  Google Scholar 

  • Boyko Y, Toft P, Ørding H, Lauridsen JT, Nikolic M, Jennum P (2019) Atypical sleep in critically ill patients on mechanical ventilation is associated with increased mortality. Sleep Breath 23:379–388

    Article  Google Scholar 

  • Brunkhorst FM, Weigand MA, Pletz M, Gastmeier P, Lemmen SW, Meier-Hellmann A, Ragaller M, Weyland A, Marx G, Bucher M, Gerlach H, Salzberger B, Grabein B, Welte T, Werdan K, Kluge S, Bone HG, Putensen C, Rossaint R, Quintel M, Spies C, Weiß B, John S, Oppert M, Jörres A, Brenner T, Elke G, Gründling M, Mayer K, Weimann A, Felbinger TW, Axer H, Deutsche Sepsis Gesellschaft e. V (2020) S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge: Langfassung [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare: long version]. Med Klin Intensivmed Notfmed 115:37–109. https://doi.org/10.1007/s00063-020-00685-0

    Article  CAS  Google Scholar 

  • Brunton (1991) Agents for control of gastric acidity and treatment peptic ulcers. In: GoodmanGilman A, Rall TW, Nies AS, Taylor P (Hrsg) Goodman & Gilman’s the pharmacological basis of therapeutics. McGraw-Hill, New York, S 897–913

    Google Scholar 

  • Bundesamt für Arzneimittel und Medizinprodukte (2022). https://www.bfarm.de/SharedDocs/Risikoinformationen/Pharmakovigilanz/DE/RV_STP/m-r/ranitidin.html. Zugegriffen am 01.02.2022

  • Burry L, Mehta S, Perreault MM, Luxenberg JS, Siddiqi N, Hutton B, Fergusson DA, Bell C, Rose L (2018) Antipsychotics for treatment of delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev 6:CD005594

    Google Scholar 

  • Caroff DA, Li L, Muscedere J, Klompas M (2016) Subglottic secretion drainage and objective outcomes: a systematic review and meta-analysis. Crit Care Med 44:830–840. https://doi.org/10.1097/CCM.0000000000001414

    Article  Google Scholar 

  • Carrasco G, Baeza N, Cabré L, Portillo E, Gimeno G, Manzanedo D, Calizaya M (2016) Dexmedetomidine for the treatment of hyperactive delirium refractory to haloperidol in nonintubated icu patients: a nonrandomized controlled trial. Crit Care Med 44(7):1295–1306

    Article  CAS  Google Scholar 

  • Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J (1999) Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27:2812–2817. https://doi.org/10.1097/00003246-199912000-00034

    Article  CAS  Google Scholar 

  • Cook D, Attia J, Weaver B et al (2000) Venous thromboembolic disease: an observational study in medical-surgical intensive care unit patients. J Crit Care 15(4):127–132. http://www.ncbi.nlm.nih.gov/pubmed/11138871

    Article  CAS  Google Scholar 

  • Cook D, Meade M, Guyatt G et al (2011) Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med 364(14):1305–1314. https://doi.org/10.1056/NEJMoa1014475

    Article  CAS  Google Scholar 

  • Cook DJ, Fuller HD, Guyatt GH, Marshall JC, Leasa D, Hall R, Winton TL, Rutledge F, Todd TJ, Roy P et al (1994) Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 10:377–381. https://doi.org/10.1056/NEJM199402103300601

    Article  Google Scholar 

  • Cox J (2011) Predictors of pressure ulcer in adult critical care patients. Am J Crit Care 20(5):364–374

    Article  Google Scholar 

  • Cox J, Roche S, Murphy V (2018) Pressure injury risk factors in critical care patients: a descriptive analysis. Adv Skin Wound Care 31(7):328–334

    Article  Google Scholar 

  • Damas P, Legrain C, Lambermont B, Dardenne N, Guntz J, Kisoka G, Demaret P, Rousseau AF, Jadot L, Piret S, Noirot D, Bertrand A, Donneau AF, Misset B (2022) Prevention of ventilator-associated pneumonia by noble metal coating of endotracheal tubes: a multi-center, randomized, double-blind study. Ann Intensive Care 12:1. https://doi.org/10.1186/s13613-021-00961-y

    Article  CAS  Google Scholar 

  • Defloor T, Grypdonck MF (2005) Pressure ulcers: validation of two risk assessment scales. J Clin Nurs 14(3):378–382

    Article  Google Scholar 

  • Demoule A, Carreira S, Lavault S, Pallanca O, Morawiec E, Mayaux J, Similowski T (2017) Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized study. Crit Care 21(1):1–9

    Article  Google Scholar 

  • Dennis CM, Lee R, Woodard EK, Szalaj JJ, Walker CA (2010) Benefits of quiet time for neuro-intensive care patients. J Neurosci Nurs 42(4):217–224

    Article  Google Scholar 

  • Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJ, Pandharipande PP, Alhazzani W (2018) Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 46:e825–e873

    Article  Google Scholar 

  • Dörffler-Melly J, de Jonge E, Pont AC et al (2002) Bioavailability of subcutaneous lowmolecular-weight heparin to patients on vasopressors. Lancet 359(9309):849–850. http://www.ncbi.nlm.nih.gov/pubmed/11897286

    Article  Google Scholar 

  • Douketis J, Cook D, Meade M, Guyatt G, Geerts W, Skrobik Y et al (2008) Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study. Arch Intern Med 168(16):1805–1812. https://doi.org/10.1001/archinte.168.16.1805

  • Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M (1999) Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 354:1851–1858. https://doi.org/10.1016/S0140-6736(98)12251-1

    Article  CAS  Google Scholar 

  • Duplaga BA, Rivers CW, Nutescu E (2001) Dosing and monitoring of low-molecular-weight heparins in special populations. Pharmacotherapy 21(2):218–234. https://doi.org/10.1592/phco.21.2.218.34112

  • Dziegielewski C, Skead C, Canturk T, Webber C, Fernando SM, Thompson LH, Kyeremanteng K (2021) Delirium and associated length of stay and costs in critically ill patients. Crit Care Res Pract 2021:6612187

    Google Scholar 

  • Eijk MM van, Van Marum RJ, Klijn IA, De Wit N, Kesecioglu J, Slooter AJ (2009) Comparison of delirium assessment tools in a mixed intensive care unit. Crit Care Med 37:1881–1885

    Google Scholar 

  • Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Dittus RS (2004) Delirium as a predictor of mortality in mechanically ventilated patients. Crit Care Med 32(11):1753–1763

    Google Scholar 

  • Finkenstedt A, Berger MM, Joannidis M (2020) Stress ulcer prophylaxis: is mortality a useful endpoint? Intensive Care Med 46:2058–2060. https://doi.org/10.1007/s00134-020-06250-9

    Article  Google Scholar 

  • Freeman S, Yorke J, Dar P (2021) Critically ill patients’ experience of agitation: a qualitative meta-synthesis. Nurs Crit Care 27:91–105

    Article  Google Scholar 

  • Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ (2001) Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA 285(22):2864–2870. https://doi.org/10.1001/jama.285.22.2864

  • Gastmeier P, Kampf G, Wischnewski N, Hauer T, Schulgen G, Schumacher M, Daschner F, Rüden H (1998) Prevalence of nosocomial infections in representative German hospitals. J Hosp Infect 38:37–49. https://doi.org/10.1016/s0195-6701(98)90173-6

    Article  CAS  Google Scholar 

  • Gastmeier P, Behnke M, Reichardt C, Geffers C (2011) Qualitätsmanagement zur Infektionsprävention im Krankenhaus. Die Bedeutung der Surveillance [Quality management for preventing healthcare-acquired infections. The importance of surveillance]. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 54:207–212. German. https://doi.org/10.1007/s00103-010-1200-2

    Article  CAS  Google Scholar 

  • Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, Colwell CW (2008) Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133(6 Suppl):381S–453S. https://doi.org/10.1378/chest.08-0656

  • Geffers C, Gastmeier P (2011) Nosocomial infections and multidrug-resistant organisms in Germany: epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int 108:87–93. https://doi.org/10.3238/arztebl.2011.0087

    Article  Google Scholar 

  • Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA, Samama CM (2012) Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e227S–e277S. https://doi.org/10.1378/chest.11-2297

  • Granholm A, Krag M, Marker S, Alhazzani W, Perner A, Møller MH (2021) Predictors of gastrointestinal bleeding in adult ICU patients in the SUP-ICU trial. Acta Anaesthesiol Scand 65:792–800. https://doi.org/10.1111/aas.13805

    Article  Google Scholar 

  • Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L, PROSEVA Study Group (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368:2159–2168. https://doi.org/10.1056/NEJMoa1214103

    Article  CAS  Google Scholar 

  • Haas S, Encke A, Kopp I (2016) German S3 practice guidelines on prevention of venous thromboembolism – new and established evidence. Dtsch Med Wochenschr 141(7):453–456. https://doi.org/10.1055/s-0042-100484

    Article  Google Scholar 

  • Halling CMB, Møller MH, Marker S, Krag M, Kjellberg J, Perner A, Gyrd-Hansen D (2022) The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial. Intensive Care Med. https://doi.org/10.1007/s00134-022-06631-2

  • Hammerstingl C, Omran H (2009) Bridging of oral anticoagulation with low-molecular-weight heparin: experience in 373 patients with renal insufficiency undergoing invasive procedures. Thrombosis and haemostasis 101(6):1085–1090

    Google Scholar 

  • Hasan SS, Radford S, Kow CS, Zaidi ST (2020) Venous thromboembolism in critically ill COVID-19 patients receiving prophylactic or therapeutic anticoagulationb: a systematic review and metra-analysis. J Thromb Thrombolysis 50:814–821. https://doi.org/10.1007/s11239-020-02235-z

    Article  CAS  Google Scholar 

  • Herling SF, Greve IE, Vasilevskis EE, Egerod I, Bekker Mortensen C, Møller AM, Svenningsen H, Thomsen T (2018) Interventions for preventing intensive care unit delirium in adults. Cochrane Database Syst Rev 11:CD009783

    Google Scholar 

  • Holt KM, Hollander D (1986) Acute gastric mucosal injury: pathogenesis and therapy. Annu Rev Med 37:107–124. https://doi.org/10.1146/annurev.me.37.020186.000543

    Article  CAS  Google Scholar 

  • Honarmand K, Rafay H, Le J, Mohan S, Rochwerg B, Devlin JW, Bosma KJ (2020) A systematic review of risk factors for sleep disruption in critically ill adults. Crit Care Med 48(7):1066–1074

    Google Scholar 

  • Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi YM, Heels-Ansdell D, Thabane L, Lamarche D, Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English S, Rochwerg B, Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox ME, Goffi A, Stelfox HT, Niven D, Muscedere J, Lamontagne F, D‘Aragon F, St-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari NK, Marquis F, Archambault P, Khwaja K, Kristof A, Kutsogiannis J, Zarychanski R, Paunovic B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Cartin-Ceba R, Taylor R, Cook D (2021) Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Effect of probiotics on incident ventilator-associated pneumonia in critically ill patients: a randomized clinical trial. JAMA 326:1024–1033. https://doi.org/10.1001/jama.2021.13355

    Article  CAS  Google Scholar 

  • Kahn SR, Lim W, Dunn AS, Cushman M, Dentali F, Akl EA et al (2012) Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e195S–e226S. https://doi.org/10.1378/chest.11-2296

  • Kamdar BB, Simons KS, Spronk PE (2020) Can ICUs create more sleep by creating less noise? Intensive Care Med 46(3):498–500

    Article  Google Scholar 

  • Kirchheiner J, Glatt S, Fuhr U, Klotz U, Meineke I, Seufferlein T, Brockmöller J (2009) Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. Eur J Clin Pharmacol 65:19–31. https://doi.org/10.1007/s00228-008-0576-5

    Article  CAS  Google Scholar 

  • Klamroth R, Gottstein S, Essers E, Landgraf H (2010) Bridging with enoxaparin using a half-therapeutic dose regimen: safety and efficacy. VASA. Zeitschrift fur Gefasskrankheiten 39(3):243–248. https://doi.org/10.1024/0301-1526/a000036

  • Klotz U (2005) Pharmakologie der Protonenpumpenhemmer [Pharmacology of proton pump inhibitors]. Pharm Unserer Zeit 34:200–204. https://doi.org/10.1002/pauz.200500119

    Article  CAS  Google Scholar 

  • Klouwenberg PM, Zaal IJ, Spitoni C, Ong DS, Van Der Kooi AW, Bonten MJ, Cremer OL (2014) The attributable mortality of delirium in critically ill patients: prospective cohort study. BMJ 349:g6652

    Article  Google Scholar 

  • Kluge S, Janssens U, Welte T et al (2021) S3-Leitlinie – Empfehlungen zur stationären Therapie von Patienten mit Covid-19. Stand 05.10.2021. AWMF-Register-Nr. 113/001. https://www.awmf.org/leitlinien/aktuelle-leitlinien.html

  • Kollef MH (2011) Prevention of nosocomial pneumonia in the intensive care unit: beyond the use of bundles. Surg Infect 12:211–220. https://doi.org/10.1089/sur.2010.060

    Article  Google Scholar 

  • Kotfis K, Marra A, Ely EW (2018) ICU delirium – a diagnostic and therapeutic challenge in the intensive care unit. Anaesthesiol Intensive Ther 50(2):160

    Article  Google Scholar 

  • Kottner J, Balzer K (2010) Do pressure ulcer risk assessment scales improve clinical practice? J Multidiscip Healthc 3:103–111

    Article  Google Scholar 

  • Kottner J, Balzer K, Dassen T, Heinze S (2009) Pressure ulcers: a critical review of definitions and classifications. Ostomy Wound Manage 55(9):22–2913

    Google Scholar 

  • Krag M, Perner A, Wetterslev J, Wise MP, Hylander Møller M (2014) Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 40:11–22. https://doi.org/10.1007/s00134-013-3125-3

    Article  CAS  Google Scholar 

  • Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjær JM, Palmqvist DF, Bäcklund M, Laake JH, Bådstøløkken PM, Grönlund J, Breum O, Walli A, Winding R, Iversen S, Jarnvig IL, White JO, Brand B, Madsen MB, Quist L, Thornberg KJ, Møller A, Wiis J, Granholm A, Anthon CT, Meyhoff TS, Hjortrup PB, Aagaard SR, Andreasen JB, Sørensen CA, Haure P, Hauge J, Hollinger A, Scheuzger J, Tuchscherer D, Vuilliomenet T, Takala J, Jakob SM, Vang ML, Pælestik KB, Andersen KLD, van der Horst ICC, Dieperink W, Fjølner J, Kjer CKW, Sølling C, Sølling CG, Karttunen J, Morgan MPG, Sjøbø B, Engstrøm J, Agerholm-Larsen B, Møller MH, SUP-ICU Trial Group (2018) Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU. N Engl J Med 379:2199–2208. https://doi.org/10.1056/NEJMoa1714919

    Article  CAS  Google Scholar 

  • Kruse MW, Lee JJ (2004) Retrospective evaluation of a pharmacokinetic program for adjusting enoxaparin in renal impairment. Am heart J 148(4):582–589. https://doi.org/10.1016/j.ahj.2004.04.015

  • Lang JK, Paykel MS, Haines K, Hodgson CL (2020) Clinical practice guidelines for early mobilization in the ICU: a systematic review. Crit Care Med 48(11):e1121–e1128

    Article  Google Scholar 

  • Lentine KL, Flavin KE, Gould MK (2005) Variability in the use of thromboprophylaxis and outcomes in critically ill medical patients. Am J Med 118(12):1373–1380. http://www.ncbi.nlm.nih.gov/pubmed/16378781

    Article  Google Scholar 

  • Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK (2008) One-year health care costs associated with delirium in the elderly population. Arch Intern Med 168:27–32

    Article  Google Scholar 

  • Limpus A, Chaboyer W, McDonald E et al (2006) Mechanical thromboprophylaxis in critically ill patients: a systematic review and meta-analysis. Am J Crit Care 15(4):402–412. http://www.ncbi.nlm.nih.gov/pubmed/16823018

    Article  Google Scholar 

  • Luo W, **ng R, Wang C (2021) The effect of ventilator-associated pneumonia on the prognosis of intensive care unit patients within 90 days and 180 days. BMC Infect Dis 21:684. https://doi.org/10.1186/s12879-021-06383-2

    Article  Google Scholar 

  • Mahmoodpoor A, Peyrovi-far A, Hamishehkar H, Bakhtyiari Z, Mirinezhad MM, Hamidi M, Golzari SE (2013) Comparison of prophylactic effects of polyurethane cylindrical or tapered cuff and polyvinyl chloride cuff endotracheal tubes on ventilator-associated pneumonia. Acta Med Iran 51:461–466

    Google Scholar 

  • Marker S, Perner A, Wetterslev J, Krag M, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Møller MH, SUP-ICU Investigators (2019) Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial. Intensive Care Med 45:609–618. https://doi.org/10.1007/s00134-019-05589-y

    Article  CAS  Google Scholar 

  • Marra A, Ely EW, Pandharipande P, Patel MB (2017) The ABCDEF bundle in critical care. Crit Care Clin 33(2):225–243

    Article  Google Scholar 

  • Marsh PD (2010) Controlling the oral biofilm with antimicrobials. J Dent 38(Suppl 1):S11–S15. https://doi.org/10.1016/S0300-5712(10)70005-1

    Article  CAS  Google Scholar 

  • McInnes E, Jammali-Blasi A, Bell-Syer SE, Dumville JC, Middleton V, Cullum N (2011) Support surfaces for pressure ulcer prevention. Cochrane Database Syst Rev 4:CD001735

    Google Scholar 

  • Morandi A, Piva S, Ely EW, Myatra SN, Salluh JI, Amare D, Latronico N (2017) Worldwide ABCDEF (Assessing pain, both spontaneous awakening and breathing trials, choice of drugs, delirium monitoring/management, early exercise/mobility, and family empowerment) survey. Crit Care Med 45(11):e1111

    Article  Google Scholar 

  • Morandi A, Pozzi C, Milisen K, Hobbele H, Bottomley JM, Lanzoni A, Bellelli G (2019) An interdisciplinary statement of scientific societies for the advancement of delirium care across Europe (EDA, EANS, EUGMS, COTEC, IPTOP/WCPT). BMC Geriatr 19(1):1–11

    Article  Google Scholar 

  • Morris RJ, Woodcock JP (2010) Intermittent pneumatic compression or graduated compression stockings for deep vein thrombosis prophylaxis? A systematic review of direct clinical comparisons. Ann Surg 251(3):393–396. https://doi.org/10.1097/SLA.0b013e3181b5d61c

  • Müller A, Weiß B, Spies CD (2015) Analgesie, Sedierung und Delirmanagement–Die neue S3-Leitlinie „Analgesie, Sedierung und Delirmanagement in der Intensivmedizin AINS-Anästhesiologie“. Intensivmedizin Notfallmedizin Schmerztherapie 50(11/12):698–703. (z. Z. in Überarbeitung)

    Google Scholar 

  • Muscedere J, Dodek P, Keenan S, Fowler R, Cook D, Heyland D, VAP Guidelines Committee and the Canadian Critical Care Trials Group (2008) Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care 23:126–137. https://doi.org/10.1016/j.jcrc.2007.11.014

    Article  Google Scholar 

  • National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel and Pan Pacific Pressure Injury Alliance (2014) Prevention and treatment of pressure ulcers: quick reference guide (Hrsg. E Haesler). Cambridge Media, Osborne Park

    Google Scholar 

  • Nieuwenhoven CA van, Vandenbroucke-Grauls C, van Tiel FH, Joore HC, van Schijndel RJ, van der Tweel I, Ramsay G, Bonten MJ (2006) Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 34:396–402. https://doi.org/10.1097/01.ccm.0000198529.76602.5e

  • Nopp S, Moik F, Jilma B et al (2020) Risk of venous thromboembolism in patients with Covid-19: a systematic review and meta-analysis. Res Pract Thromb Haemost 4(7):1178–1191. https://doi.org/10.1002/rth2.12429

    Article  CAS  Google Scholar 

  • Nylund CM, Goudie A, Garza JM, Crouch G, Denson LA (2013) Venous thrombotic events in hospitalized children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 56(5):485–491. https://doi.org/10.1097/MPG.0b013e3182801e43

  • Ortega DG, Papathanassoglou E, Norris CM (2020) The lived experience of delirium in intensive care unit patients: a meta-ethnography. Aust Crit Care 33(2):193–202

    Article  Google Scholar 

  • Pancorbo-Hidalgo PL, Garcia-Fernandez FP, Lopez-Medina IM, Alvarez-Nieto C (2006) Risk assessment scales for pressure ulcer prevention: a systematic review. J Adv Nurs 54(1):94–100

    Article  Google Scholar 

  • Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Ely EW (2006) Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104(1):21–26

    Article  CAS  Google Scholar 

  • Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Ely EW (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369:1306–1316

    Article  CAS  Google Scholar 

  • Pisani MA, D’Ambrosio C (2020) Sleep and delirium in adults who are critically ill: a contemporary review. Chest 157(4):977–984

    Article  Google Scholar 

  • Pozuelo-Carrascosa DP, Cobo-Cuenca AI, Carmona-Torres JM, Laredo-Aguilera JA, Santacruz-Salas E, Fernandez-Rodriguez R (2022) Body position for preventing ventilator-associated pneumonia for critically ill patients: a systematic review and network meta-analysis. J Intensive Care 10:9. https://doi.org/10.1186/s40560-022-00600-z

    Article  Google Scholar 

  • Priglinger U, le Karth G, Geppert A et al (2003) Prophylactic anticoagulation with enoxaparin: is the subcutaneous route appropriate in the critically ill? Crit Care Med 31(5):1405–1409. http://www.ncbi.nlm.nih.gov/pubmed/12771610

    Article  CAS  Google Scholar 

  • Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Australian and New Zealand Intensive Care Society Clinical Trials Group (2016) Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial. JAMA 315(14):1460–1468

    Article  CAS  Google Scholar 

  • Rello J, Soñora R, Jubert P, Artigas A, Rué M, Vallés J (1996) Pneumonia in intubated patients: role of respiratory airway care. Am J Respir Crit Care Med 154:111–115. https://doi.org/10.1164/ajrccm.154.1.8680665

    Article  CAS  Google Scholar 

  • Rocha AT, Vasconcellos AG de, Da Luz Neto ER, Araújo, DMA, Alves ES, Lopes AA (2006) Risk of venous thromboembolism and efficacy of thromboprophylaxis in hospitalized obese medical patients and in obese patients undergoing bariatric surgery. Obes Surg 16(12):1645–1655. https://doi.org/10.1381/096089206779319383

  • Rompaey B van, Elseviers MM, Schuurmans MJ, Shortridge-Baggett LM, Truijen S, Bossaert L (2009) Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care 13(3):1–12

    Google Scholar 

  • Rompaey B van, Elseviers MM, Van Drom W, Fromont V, Jorens PG (2012) The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Crit Care 16(3):1–11

    Google Scholar 

  • Rondina MT, Wheeler M, Rodgers GM, Draper L, Pendleton RC (2010) Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-Ill patients. Thromb Res 125(3):220–223. https://doi.org/10.1016/j.thromres.2009.02.003

  • Rosa RG, Tonietto TF, da Silva DB, Gutierres FA, Ascoli AM, Madeira LC, Teixeira C (2017) Effectiveness and safety of an extended ICU visitation model for delirium prevention: a before and after study. Crit Care Med 45(10):1660–1667

    Article  Google Scholar 

  • Rouzé A, Nseir S (2013) Continuous control of tracheal cuff pressure for the prevention of ventilator-associated pneumonia in critically ill patients: where is the evidence? Curr Opin Crit Care 19:440–447. https://doi.org/10.1097/MCC.0b013e3283636b71

    Article  Google Scholar 

  • Ryan D, O’Regan N, Caoimh R, Clare J, O’Connor M, Leonard M, Timmons S (2013) Delirium in an adult acute hospital population: predictors, prevalence and detection. BMJ Open 3(1):e001772

    Article  Google Scholar 

  • Saito M, Maruyama K, Mihara T, Hoshijima H, Hirabayashi G, Andoh T (2021) Comparison of polyurethane tracheal tube cuffs and conventional polyvinyl chloride tube cuff for prevention of ventilator-associated pneumonia: a systematic review with meta-analysis. Medicine (Baltimore) 100:e24906. https://doi.org/10.1097/MD.0000000000024906

    Article  Google Scholar 

  • Salluh JI, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, Stevens RD (2015) Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ 350:h2538

    Article  Google Scholar 

  • Scannapieco FA, Stewart EM, Mylotte JM (1992) Colonization of dental plaque by respiratory pathogens in medical intensive care patients. Crit Care Med 20:740–745. https://doi.org/10.1097/00003246-199206000-00007

    Article  CAS  Google Scholar 

  • Scholten DJ, Hoedema RM, Scholten SE (2002) A comparison of two different prophylactic dose regimens of low molecular weight heparin in bariatric surgery. Obes Surg 12(1):19–24. https://doi.org/10.1381/096089202321144522

  • Schwahn-Schreiber C, Breu FX, Rabe E, Buschmann I, Döller W, Lulay GR et al (2018) S1-Leitlinie Intermittierende Pneumatische Kompression (IPK, AIK). Der Hautarzt 69(8):662–673. https://doi.org/10.1007/s00105-018-4219-1

  • Shankar KN, Hirschman KB, Hanlon AL, Naylor MD (2014) Burden in caregivers of cognitively impaired elderly adults at time of hospitalization: a cross-sectional analysis. J Am Geriatr Soc 62:276–284

    Article  Google Scholar 

  • Sherman RA, Hwang ER, Walker JA, Eisinger RP (1983) Reduction in serum phosphorus due to sucralfate. Am J Gastroenterol 78:210–211

    CAS  Google Scholar 

  • Simons KS, Van den Boogaard M, Jager CP (2019) Impact of intensive care unit light and noise exposure on critically ill patients. Neth J Crit Care 27(4):145–149

    Google Scholar 

  • Smet AM de, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS, van der Hoeven JG, Pickkers P, Bogaers-Hofman D, van der Meer NJ, Bernards AT, Kuijper EJ, Joore JC, Leverstein-van Hall MA, Bindels AJ, Jansz AR, Wesselink RM, de Jongh BM, Dennesen PJ, van Asselt GJ, te Velde LF, Frenay IH, Kaasjager K, Bosch FH, van Iterson M, Thijsen SF, Kluge GH, Pauw W, de Vries JW, Kaan JA, Arends JP, Aarts LP, Sturm PD, Harinck HI, Voss A, Uijtendaal EV, Blok HE, Thieme Groen ES, Pouw ME, Kalkman CJ, Bonten MJ (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20–31. https://doi.org/10.1056/NEJMoa0800394

  • Song H, Hu W, Zhou X, Tao J, Zhang S, Su X, Wu W (2022) Clinical benefits from administering probiotics to mechanical ventilated patients in intensive care unit: a PRISMA-guided meta-analysis. Front Nutr 8:798827. https://doi.org/10.3389/fnut.2021.798827

    Article  Google Scholar 

  • Starlinger M, Schiessel R (1988) Bicarbonate (HCO3) delivery to the gastroduodenal mucosa by the blood: its importance for mucosal integrity. Gut 29:647–654. https://doi.org/10.1136/gut.29.5.647

    Article  CAS  Google Scholar 

  • Susen S, Tacquard CA, Godon A et al (2020) Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring. Crit Care 24:364–371. https://doi.org/10.1186/s13054-020-03000-7

    Article  Google Scholar 

  • Tacquard C, Mansour A, Godon A et al (2021) Impact of high-dose prophylactic anticoagulation in critically ill patients with COVID-19 pneumoinia. Chest 159(6):2417–2427. https://doi.org/10.1016/j.chest.2021.01.017

    Article  CAS  Google Scholar 

  • Tampi R, Tampi DJ, Ghori AK (2016) Acetylcholinesterase inhibitors for delirium in older adults. Am J Alzheimers Dis Other Dement 31(4):305–310

    Article  Google Scholar 

  • Tarnawski AS, Ahluwalia A, Jones MK (2012) The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem 19:4–15. https://doi.org/10.2174/092986712803414079

    Article  CAS  Google Scholar 

  • Teodorczuk A, MacLullich A (2018) New waves of delirium understanding. Int J Geriatr Psychiatry 33:1417–1419

    Article  Google Scholar 

  • Tomova-Simitchieva T, Akdeniz M, Blume-Peytavi U, Lahmann N, Kottner J (2019) Die Epidemiologie des Dekubitus in Deutschland: eine systematische Übersicht. Das Gesundheitswesen 81(6):505–512

    Article  Google Scholar 

  • Trompeo AC, Vidi Y, Locane MD, Braghiroli A, Mascia L, Bosma K, Ranieri VM (2011) Sleep disturbances in the critically ill patients: role of delirium and sedative agents. Minerva Anesthesiol 77:604–612

    CAS  Google Scholar 

  • Vanderwee K, Grypdonck MHF, De Bacquer D, Defloor T (2007) Effectiveness of turning with unequal time intervals on the incidence of pressure lesions. J Adv Nurs 57(1):59–68

    Article  CAS  Google Scholar 

  • Vasilevskis EE, Ely EW, Speroff T, Pun BT, Boehm L, Dittus RS (2010) Reducing Iatrogenic risks. ICU-acquired delirium and weakness – crossing the quality chasm. Chest 138(5):1224–1233

    Article  Google Scholar 

  • Wang Y, Ye Z, Ge L, Siemieniuk RAC, Wang X, Wang Y, Hou L, Ma Z, Agoritsas T, Vandvik PO, Perner A, Møller MH, Guyatt GH, Liu L (2020) Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis. BMJ 368:l6744. https://doi.org/10.1136/bmj.l6744

    Article  Google Scholar 

  • Wen Z, Zhang H, Ding J, Wang Z, Shen M (2017) Continuous versus intermittent subglottic secretion drainage to prevent ventilator-associated pneumonia: a systematic review. Crit Care Nurse 37:e10–e17. https://doi.org/10.4037/ccn2017940

    Article  Google Scholar 

  • Wen Z, Wei L, Chen J, **e A, Li M, Bian L (2019) Is continuous better than intermittent control of tracheal cuff pressure? A meta-analysis. Nurs Crit Care 24:76–82. https://doi.org/10.1111/nicc.12393

    Article  Google Scholar 

  • Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, Van Gool WA (2010) Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA 304:443–451

    Article  CAS  Google Scholar 

  • Xu P, Yi Q, Wang C, Zeng L, Olsen KM, Zhao R, Jiang M, Xu T, Zhang L (2021) Pharmacist-led intervention on the inappropriate use of stress ulcer prophylaxis pharmacotherapy in intensive care units: a systematic review. Front Pharmacol 25:741724. https://doi.org/10.3389/fphar.2021.741724

    Article  Google Scholar 

  • Young T (2004) The 30° tilt position vs the 90° lateral and supine positions in reducing the incidence of non-blanching erythema in a hospital inpatient population: a randomized controlled trial. J Tissue Viabil 14(3):89–96

    Article  Google Scholar 

  • Yu A, Wu S, Zhang Z, Dening T, Zhao S, Pinner G, Yang D (2018) Cholinesterase inhibitors for the treatment of delirium in non-ICU settings. Cochrane Database Syst Rev 6:CD012494

    Google Scholar 

  • Zhao T, Wu X, Zhang Q, Li C, Worthington HV, Hua F (2020) Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev 12:CD008367. https://doi.org/10.1002/14651858.CD008367.pub4

    Article  Google Scholar 

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Bingold, T.M., Hoffmann, M., Krotsetis, S., Muhl, E. (2023). Prophylaxen. In: Marx, G., Muhl, E., Zacharowski, K., Zeuzem, S. (eds) Die Intensivmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54675-4_43-2

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    Prophylaxen
    Published:
    12 February 2023

    DOI: https://doi.org/10.1007/978-3-642-54675-4_43-2

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    Prophylaxen in der Intensivmedizin
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    14 September 2015

    DOI: https://doi.org/10.1007/978-3-642-54675-4_43-1

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