Abstract
In hemophilia A, determination of factor VIII activity is used to classify the extent of impaired hemostasis and to estimate bleeding risks of patients. In contrast, the now established assays of thrombin generation (TGA) (1, 2) are not based on a single clotting factor, but are reflecting the action of the total clotting mechanism. Especially in hemophilic patients, TGA offers the possibility to monitor the treatment with haemostatic agents.
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References
Hemker HC, Al Dieri R, Beguin S: Thrombin generation assays: accruing clinical relevance.: Curr Opin Hematol (2004) 11: 170–175
Varadi K, Turecek PL, Schwarz HP: Thrombin generation assay and other universal tests for monitoring haemophilia therapy. Haemophilia (2004) 10(Suppl. 2): 17–21
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© 2008 Springer-Verlag Berlin Heidelberg
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Wenzel, F., Brackmann, H.H., Oldenburg, J. (2008). Dynamic of Thrombin Generation in Patients with Severe Hemophilia A. In: Scharrer, I., Schramm, W. (eds) 37th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73535-9_26
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DOI: https://doi.org/10.1007/978-3-540-73535-9_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-73534-2
Online ISBN: 978-3-540-73535-9
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