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Stem Cells Commitment on Graphene-Based Scaffolds

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Graphene-based Materials in Health and Environment

Part of the book series: Carbon Nanostructures ((CARBON))

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Abstract

In the last years, a rapid development in production, and functionalization of graphene give rise to several products that have shown great potentials in many fields, such as nanoelectronics, energy technology, sensors, and catalysis. In this context we should not forget the biomedical application of graphene that became a new area with outstanding potential. The first study on graphene for biomedical applications has been performed by Dai in 2008 that reported the use of graphene oxide as an efficient nanocarrier for drug delivery. This pioneristic study opened the doors for the use of graphene in widespread biomedical applications such as drug/gene delivery, biological sensing and imaging, antibacterial materials, but also as biocompatible scaffold for cell culture and tissue engineering. The application of graphene-based scaffolds for tissue engineering applications is confirmed by the many exciting and intriguing literature reports over the last few years, that clearly confirm that graphene and its related substrates are excellent platforms for adhesion, proliferation, and differentiation of various cells such as human Mesenchymal stem cells, human neuronal stem cells, and induced pluripotent stem cells. Since most of the papers on this fields are related to in vitro studies, several future in vivo investigations need to be conducted in order to lead to its utilization as implantable tissue engineering material.

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Authors and Affiliations

  1. Nanomedicine Lab, Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, University of Manchester, Manchester, M13 9PT, UK

    Maurizio Buggio

  2. Research and Development in Biomedicine, Stem Cells Unit, Tecnologica Research Institute, Crotone, Italy

    Marco Tatullo

  3. Department of Neurosciences, University of Padova, Padua, Italy

    Stefano Sivolella

  4. Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131, Padua, Italy

    Chiara Gardin, Letizia Ferroni & Barbara Zavan

  5. Department of Oral Rehabilitation, the Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Eitan Mijiritsky

  6. Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio”, Via dei Vestini 31, 66100, Chieti, Italy

    Adriano Piattelli

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  1. Maurizio Buggio
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  2. Marco Tatullo
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  3. Stefano Sivolella
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  4. Chiara Gardin
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  5. Letizia Ferroni
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  6. Eitan Mijiritsky
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  7. Adriano Piattelli
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  8. Barbara Zavan
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Correspondence to Barbara Zavan .

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  1. Nanoengineering Research Division, Department of Mechanical Engineering, Centre for Mechanical Technology and Automation, University of Aveiro, Aveiro, Portugal

    Gil Gonçalves

  2. Nanoengineering Research Division, Department of Mechanical Engineering, Centre for Mechanical Technology and Automation, University of Aveiro, Aveiro, Portugal

    Paula Marques

  3. Nanoengineering Research Division, Department of Mechanical Engineering, Centre for Mechanical Technology and Automation, University of Aveiro, Aveiro, Portugal

    Mercedes Vila

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Buggio, M. et al. (2016). Stem Cells Commitment on Graphene-Based Scaffolds. In: Gonçalves , G., Marques, P., Vila, M. (eds) Graphene-based Materials in Health and Environment. Carbon Nanostructures. Springer, Cham. https://doi.org/10.1007/978-3-319-45639-3_4

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