Abstract
Despite advancements in cancer treatment, the efficacy of current clinical therapies is still limited. Ferroptosis, an iron-dependent form of regulated cell death induced by excessive lipid peroxidation, has emerged as a potential avenue for the treatment of drug-resistant cancer cells. However, the resistance to ferroptosis still poses a challenge to the effectiveness of current ferroptosis-based cancer therapies. This chapter reviews the strategies and challenges associated with the use of iron oxide nanoparticles and gene therapy for cancer ferroptosis treatment. Based on this review, a novel safety combination therapy of iron oxide nanoparticles and gene therapy is proposed as a potential solution for overcoming ferroptosis resistance. Finally, the superiority and future research trends of combinatorial ferroptosis therapy are highlighted.
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Luo, T., Wang, J. (2023). Cancer Treatment with Ferroptosis by a Combination of Iron Nanoparticles and Gene Therapy. In: Tang, D. (eds) Ferroptosis in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-39171-2_21
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