Quantitative Fluorescent Detection of Ions

  • Chapter
  • First Online:
Introduction to Fluorescence Sensing

Abstract

This Chapter covers the basic knowledge and recent developments on quantitative detection of small ionic species. The broad diversity of approaches exists regarding selection and operation of recognition units. Meantime, three major principles in fluorescence reporting dominate in ion sensing. They are the ionization behavior of coupled to fluorophore charged groups, the modulation of photophysical processes in fluorophore (such as electron, proton, charge and energy transfers) and chemodosimetry (chemical transformations in fluorophore changing its fluorescence). The possibilities for obtaining the wavelength-ratiometric reporting signal in these cases are highlighted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
GBP 19.95
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
GBP 111.50
Price includes VAT (United Kingdom)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
GBP 139.99
Price includes VAT (United Kingdom)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
GBP 139.99
Price includes VAT (United Kingdom)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adotey EK, Torkmahalleh MA, Balanay MP (2020) Zinc metal–organic framework with 3-pyridinecarboxaldehyde and trimesic acid as co-ligands for selective detection of Cr (VI) ions in aqueous solution. Methods Appl Fluoresc 8:045007

    Article  CAS  PubMed  Google Scholar 

  • Ando Y, Hiruta Y, Citterio D, Suzuki K (2009) A highly Li+-selective glass optode based on fluorescence ratiometry. Analyst 134:2314–2319

    Article  CAS  PubMed  Google Scholar 

  • Aragay G, Pons J, Merkoçi A (2011) Recent trends in macro-, micro-, and nanomaterial-based tools and strategies for heavy-metal detection. Chem Rev 111:3433–3458

    Article  CAS  PubMed  Google Scholar 

  • Ashton TD, Jolliffe KA, Pfeffer FM (2015) Luminescent probes for the bioimaging of small anionic species in vitro and in vivo. Chem Soc Rev 44:4547–4595

    Article  CAS  PubMed  Google Scholar 

  • Au-Yeung HY, New EJ, Chang CJ (2012) A selective reaction-based fluorescent probe for detecting cobalt in living cells. Chem Commun 48:5268–5270

    Article  CAS  Google Scholar 

  • Bergamini G, Marchi E, Ceroni P (2010) Luminescent dendrimers as ligands and sensors of metal ions. In Advanced fluorescence reporters in chemistry and biology II, pp 253–284. Springer

    Google Scholar 

  • Bigdeli A, Ghasemi F, AbbasiMoayed S, Shahrajabian M, FahimiKashani N, Jafarinejad S, Nejad MAF, HormoziNezhad MR (2019) Ratiometric fluorescent nanoprobes for visual detection: Design principles and recent advances-A review. Anal Chim Acta 1079:30–58

    Article  CAS  PubMed  Google Scholar 

  • Borisov SM, Wolfbeis OS (2008) Optical biosensors. Chem Rev 108:423–461

    Article  CAS  PubMed  Google Scholar 

  • Bozdemir OA, Sozmen F, Buyukcakir O, Guliyev R, Cakmak Y, Akkaya EU (2010) Reaction-based sensing of fluoride ions using built-in triggers for intramolecular charge transfer and photoinduced electron transfer. Org Lett 12:1400–1403

    Article  CAS  PubMed  Google Scholar 

  • Bu D, Song H, Li Z, Wei L, Zhang H, Yu M (2020) Carbon-dot-based ratiometric fluorescent probe of intracellular zinc ion and persulfate ion with low dark toxicity. Luminescence 35:1319–1327

    Article  CAS  PubMed  Google Scholar 

  • Bunzli JCG, Piguet C (2005) Taking advantage of luminescent lanthanide ions. Chem Soc Rev 34:1048–1077

    Article  CAS  PubMed  Google Scholar 

  • Busschaert N, Caltagirone C, Van Rossom W, Gale PA (2015) Applications of supramolecular anion recognition. Chem Rev 115:8038–8155

    Article  CAS  PubMed  Google Scholar 

  • Chen C-L, Chen Y-T, Demchenko AP, Chou P-T (2018) Amino proton donors in excited-state intramolecular proton-transfer reactions. Nat Rev Chem 2:131–143

    Article  CAS  Google Scholar 

  • Chen G, Guo Z, Zeng G, Tang L (2015) Fluorescent and colorimetric sensors for environmental mercury detection. Analyst 140:5400–5443

    Article  CAS  PubMed  Google Scholar 

  • Chen L, Liu D, Peng J, Du Q, He H (2020) Ratiometric fluorescence sensing of metal-organic frameworks: Tactics and perspectives. Coord Chem Rev 404:213113

    Article  CAS  Google Scholar 

  • Chen L, Park SJ, Wu D, Kim HM, Yoon J (2019) A two-photon fluorescent probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues. Chem Commun 55:1766–1769

    Article  CAS  Google Scholar 

  • Cheng D, Liu X, **e Y, Lv H, Wang Z, Yang H, Han A, Yang X, Zang L (2017) A ratiometric fluorescent sensor for Cd2+ based on internal charge transfer. Sensors 17:2517

    Article  PubMed  PubMed Central  Google Scholar 

  • Csernoch L, Bernengo JC, Szentesi P, Jacquemond V (1998) Measurements of intracellular Mg2+ concentration in mouse skeletal muscle fibers with the fluorescent indicator mag-indo-1. Biophys J 75:957–967

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Davenport LD, Knutson JR, Brand L (1986) Excited-state proton transfer of equilenin and dihydro equilenin: inreractions with bilayer vesicles. Biochemistry 25:1186–1195

    Article  CAS  PubMed  Google Scholar 

  • Demchenko AP (2010) The concept of λ-ratiometry in fluorescence sensing and imaging. J Fluoresc 20:1099–1128

    Article  PubMed  Google Scholar 

  • Demchenko AP (2014) Practical aspects of wavelength ratiometry in the studies of intermolecular interactions. J Mol Struct 1077:51–67

    Google Scholar 

  • Demchenko AP (2023a) Tutorial Dual emission and its λ-ratiometric detection in analytical fluorimetry. Pt. I. Basic mechanisms of generating the reporter signal. Methods Appl Fluoresc 11:101095

    Google Scholar 

  • Demchenko AP (2023b) Tutorial Dual emission and its λ-ratiometric detection in analytical fluorimetry. Pt. II. Exploration in sensing and imaging. Methods Appl Fluoresc 11:101096

    Google Scholar 

  • Demchenko AP, Tang K-C, Chou P-T (2013) Excited-state proton coupled charge transfer modulated by molecular structure and media polarization. Chem Soc Rev 42:1379–1408

    Article  CAS  PubMed  Google Scholar 

  • Despa S, Vecer J, Steels P, Ameloot M (2000) Fluorescence lifetime microscopy of the Na+ indicator Sodium Green in HeLa cells. Anal Biochem 281:159–175

    Article  CAS  PubMed  Google Scholar 

  • Dhiman S, Ahmad M, Singla N, Kumar G, Singh P, Luxami V, Kaur N, Kumar S (2020) Chemodosimeters for optical detection of fluoride anion. Coord Chem Rev 405:213138

    Article  CAS  Google Scholar 

  • Dutta M, Das D (2012) Recent developments in fluorescent sensors for trace-level determination of toxic-metal ions. TrAC, Trends Anal Chem 32:113–132

    Article  CAS  Google Scholar 

  • Falcone E, Okafor M, Vitale N, Raibaut L, Sour A, Faller P (2021) Extracellular Cu2+ pools and their detection: From current knowledge to next-generation probes. Coord Chem Rev 433:213727

    Article  CAS  Google Scholar 

  • Gale PA, Caltagirone C (2015) Anion sensing by small molecules and molecular ensembles. Chem Soc Rev 44:4212–4227

    Article  CAS  PubMed  Google Scholar 

  • Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440–3450

    Article  CAS  PubMed  Google Scholar 

  • Guo Z, Kim G-H, Yoon J, Shin I (2014) Synthesis of a highly Zn 2+-selective cyanine-based probe and its use for tracing endogenous zinc ions in cells and organisms. Nature Protocols 9: 1245–1254

    Google Scholar 

  • Gupta A, Kumar N (2016) A review of mechanisms for fluorescent ‘“turn-on”’probes to detect Al 3+ ions. RSC Adv 6:106413–106434

    Article  CAS  Google Scholar 

  • Han J, Burgess K (2010) Fluorescent indicators for intracellular pH. Chem Rev 110:2709–2728

    Article  CAS  PubMed  Google Scholar 

  • Han J, Zhang J, Gao M, Hao H, Xu X (2019) Recent advances in chromo-fluorogenic probes for fluoride detection. Dyes Pigm 162:412–439

    Article  CAS  Google Scholar 

  • Han Y, Yang W, Luo X, He X, Zhao H, Tang W, Yue T, Li Z (2020) Carbon dots based ratiometric fluorescent sensing platform for food safety. Crit Rev Food Sci Nutr: 1–17

    Google Scholar 

  • Hanson GT, McAnaney TB, Park ES, Rendell ME, Yarbrough DK, Chu S, ** L, Boxer SG, Montrose MH, Remington SJ (2002) Green fluorescent protein variants as ratiometric dual emission pH sensors 1 structural characterization and preliminary application. Biochemistry 41:15477–15488

    Article  CAS  PubMed  Google Scholar 

  • Haugland R (2003) Molecular probes product information and catalogue. Eugene, OR: Molecular Probes

    Google Scholar 

  • Henary MM, Wu Y, Cody J, Sumalekshmy S, Li J, Mandal S, Fahrni CJ (2007) Excited-state intramolecular proton transfer in 2-(2 ‘-arylsulfonamidophenyl) benzimidazole derivatives: The effect of donor and acceptor substituents. J Org Chem 72:4784–4797

    Article  CAS  PubMed  Google Scholar 

  • Hong K-I, Park S-H, Lee SM, Shin I, Jang W-D (2019) A pH-sensitive excited state intramolecular proton transfer fluorescent probe for imaging mitochondria and Helicobacter pylori. Sens Actuators, B Chem 286:148–153

    Article  CAS  Google Scholar 

  • Hsieh CC, Ho ML, Chou PT (2010) Organic dyes with excited-state transformations (electron, charge, and proton transfers). In Advanced fluorescence reporters in chemistry and biology I, pp 225–266. Springer

    Google Scholar 

  • Hu R, Feng J, Hu D, Wang S, Li S, Li Y, Yang G (2010) A rapid aqueous fluoride ion sensor with dual output modes. Angew Chem Int Ed 49:4915–4918

    Article  CAS  Google Scholar 

  • Huang CC, Chang HT (2006) Selective gold-nanoparticle-based “turn-on” fluorescent sensors for detection of mercury(II) in aqueous solution. Anal Chem 78:8332–8338

    Article  CAS  PubMed  Google Scholar 

  • Huang Q, Zhang Q, Wang E, Zhou Y, Qiao H, Pang L, Yu F (2016) A new “off–on” fluorescent probe for Al3+ in aqueous solution based on rhodamine B and its application to bioimaging. Spectrochim Acta Part A Mol Biomol Spectrosc 152:70–76

    Article  CAS  Google Scholar 

  • Huang X, Song J, Yung BC, Huang X, **ong Y, Chen X (2018) Ratiometric optical nanoprobes enable accurate molecular detection and imaging. Chem Soc Rev 47:2873–2920

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hwang GW, Jeon J, Neupane LN, Lee K-H (2018) Sensitive ratiometric detection of Al (III) ions in a 100% aqueous buffered solution using a fluorescent probe based on a peptide receptor. New J Chem 42:1437–1445

    Article  CAS  Google Scholar 

  • Jayaraman S, Biwersi J, Verkman A (1999) Synthesis and characterization of dual-wavelength Cl−-sensitive fluorescent indicators for ratio imaging. Am J Physiol Cell Physiol 276:C747–C757

    Article  CAS  Google Scholar 

  • Jiao Y, Liu X, Zhou L, He H, Zhou P, Duan C (2017) A schiff-base dual emission ratiometric fluorescent chemosensor for Hg2+ ions and its application in cellular imaging. Sens Actuators, B Chem 247:950–956

    Article  CAS  Google Scholar 

  • ** H-G, Zong W, Yuan L, Zhang X-B (2018) Nanoscale zeolitic imidazole framework-90: selective, sensitive and dual-excitation ratiometric fluorescent detection of hazardous Cr (VI) anions in aqueous media. New J Chem 42:12549–12556

    Article  CAS  Google Scholar 

  • Kamenica M, Kothur RR, Willows A, Patel BA, Cragg PJ (2017) Lithium ion sensors. Sensors 17:2430

    Article  PubMed  PubMed Central  Google Scholar 

  • Kang J, Huo F, Zhang Y, Chao J, Glass TE, Yin C (2019) A novel near-infrared ratiometric fluorescent probe for cyanide and its bioimaging applications. Spectrochim Acta Part A Mol Biomol Spectrosc 209:95–99

    Article  CAS  Google Scholar 

  • Kim HJ, Lim CS, Lee HW, Lee HS, Um YJ, Kumar H, Han I, Kim HM (2017) A ratiometric two-photon probe for Ca2+ in live tissues and its application to spinal cord injury model. Biomaterials 141:251–259

    Article  CAS  PubMed  Google Scholar 

  • Klymchenko AS, Demchenko AP (2002) Electrochromic modulation of excited-state intramolecular proton transfer: the new principle in design of fluorescence sensors. J Am Chem Soc 124:12372–12379

    Article  CAS  PubMed  Google Scholar 

  • Klymchenko AS, Demchenko AP (2004) 3-Hydroxychromone dyes exhibiting excited-state intramolecular proton transfer in water with efficient two-band fluorescence. New J Chem 28:687–692

    Article  CAS  Google Scholar 

  • Konishi K, Hiratani T (2006) Turn-on and selective luminescence sensing of copper ions by a water-soluble Cd10S16 molecular cluster. Angew Chem Int Ed Engl 45:5191–5194

    Article  CAS  PubMed  Google Scholar 

  • Kubik S (2017) Anion recognition in aqueous media by cyclopeptides and other synthetic receptors. Acc Chem Res 50:2870–2878

    Article  CAS  PubMed  Google Scholar 

  • Kumar P, Kim K-H, Bansal V, Lazarides T, Kumar N (2017) Progress in the sensing techniques for heavy metal ions using nanomaterials. J Ind Eng Chem 54:30–43

    Article  CAS  Google Scholar 

  • Lakowicz JR (2007) Principles of fluorescence spectroscopy, 3-d ed. Springer Science & Business Media

    Google Scholar 

  • Laws WR, Brand L (1979) Analysis of two-state excited-state reactions. The fluorescence decay of 2-naphthol. J Phys Chem 83:795–802

    Google Scholar 

  • Li CY, Zhang XB, Han ZX, Akermark B, Sun L, Shen GL, Yu RQ (2006) A wide pH range optical sensing system based on a sol-gel encapsulated amino-functionalized corrole. Analyst 131:388–393

    Article  CAS  PubMed  Google Scholar 

  • Li H, Zhu H, Sun M, Yan Y, Zhang K, Huang D, Wang S (2015) Manipulating the surface chemistry of quantum dots for sensitive ratiometric fluorescence detection of sulfur dioxide. Langmuir 31:8667–8671

    Article  CAS  PubMed  Google Scholar 

  • Li P, Zhang S, Fan N, **ao H, Zhang W, Zhang W, Wang H, Tang B (2014) Quantitative fluorescence ratio imaging of intralysosomal chloride ions with single excitation/dual maximum emission. Chem Eur J 20: 11760–11767

    Google Scholar 

  • Lin B, Fan L, Ying Z, Ge J, Wang X, Zhang T, Dong C, Shuang S, Wong MS (2020) The ratiometric fluorescent probe with high quantum yield for quantitative imaging of intracellular pH. Talanta 208:120279

    Article  CAS  PubMed  Google Scholar 

  • Liu M, Yu X, Li M, Liao N, Bi A, Jiang Y, Liu S, Gong Z, Zeng W (2018a) Fluorescent probes for the detection of magnesium ions (Mg 2+): from design to application. RSC Adv 8:12573–12587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu S, Wang Y-M, Han J (2017) Fluorescent chemosensors for copper (II) ion: Structure, mechanism and application. J Photochem Photobiol, C 32:78–103

    Article  Google Scholar 

  • Liu S, Zhang L, Zhou P, Yang Y, Wu W (2018b) Distinctive fluoride fluorescent probes with ratiometric characteristics combinate desilylation, hydrogen bond and ESIPT process: Spectral and mechanistic studies. Sens Actuators, B Chem 255:401–407

    Article  CAS  Google Scholar 

  • Liu X, Liu X, Shen Y, Gu B (2020) A Simple Water-Soluble ESIPT Fluorescent Probe for Fluoride Ion with Large Stokes Shift in Living Cells. ACS Omega 5:21684–21688

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Z, He W, Guo Z (2013) Metal coordination in photoluminescent sensing. Chem Soc Rev 42:1568–1600

    Article  PubMed  Google Scholar 

  • Long L, Han Y, Yuan X, Cao S, Liu W, Chen Q, Wang K, Han Z (2020) A novel ratiometric near-infrared fluorescent probe for monitoring cyanide in food samples. Food Chem 331:127359

    Article  CAS  PubMed  Google Scholar 

  • Lv P, Cao Y, Liu Z, Wang R, Ye B, Li G (2020) Dual luminescent lanthanide coordination polymers for ratiometric sensing and efficient removal of Hg 2+. Anal Methods 12:91–96

    Article  CAS  Google Scholar 

  • Mahapatra AK, Mondal S, Manna SK, Maiti K, Maji R, Ali SS, Mandal D, Uddin MR, Mandal S (2016) Reaction-based sensing of fluoride ions using desilylation method for triggering excited-state intramolecular proton transfer. Supramol Chem 28:693–706

    Article  CAS  Google Scholar 

  • Maity D, Kumar V, Govindaraju T (2012) Reactive probes for ratiometric detection of Co2+ and Cu+ based on excited-state intramolecular proton transfer mechanism. Org Lett 14:6008–6011

    Article  CAS  PubMed  Google Scholar 

  • Maravall M, Mainen Z, Sabatini B, Svoboda K (2000) Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophysical J 78: 2655–2667

    Google Scholar 

  • MartínezMáñez R, Sancenón F (2005) New advances in fluorogenic anion chemosensors. J Fluoresc 15:267–285

    Article  PubMed  Google Scholar 

  • McAnaney TB, Shi X, Abbyad P, Jung H, Remington SJ, Boxer SG (2005) Green fluorescent protein variants as ratiometric dual emission pH sensors 3 temperature dependence of proton transfer. Biochemistry 44:8701–8711

    Article  CAS  PubMed  Google Scholar 

  • Mordon S, Devoisselle JM, Soulie S (1995) Fluorescence spectroscopy of pH in vivo using a dual-emission fluorophore (C-SNAFL-1). J Photochem Photobiol B 28:19–23

    Article  CAS  PubMed  Google Scholar 

  • Mukherjee S, Ganguly S, Samanta D, Das D (2019) Sustainable green route to synthesize functional nano-MOFs as selective sensing probes for CrVI oxoanions and as specific sequestering agents for Cr2O72–. ACS Sustain Chem Eng 8:1195–1206

    Article  Google Scholar 

  • Müller BJ, Borisov SM, Klimant I (2016) Red-to NIR-Emitting, BODIPY-Based, K+-Selective Fluoroionophores and Sensing Materials. Adv Func Mater 26:7697–7707

    Article  Google Scholar 

  • Neupane LN, Mehta PK, Oh S, Park S-H, Lee K-H (2018) Ratiometric red-emission fluorescence detection of Al 3+ in pure aqueous solution and live cells by a fluorescent peptidyl probe using aggregation-induced emission. Analyst 143:5285–5294

    Article  CAS  PubMed  Google Scholar 

  • Ngororabanga JMV, Tshentu ZR, Mama N (2019) A highly selective and sensitive ESIPT-based coumarin–triazole polymer for the ratiometric detection of Hg 2+. New J Chem 43:12168–12177

    Article  CAS  Google Scholar 

  • Niu CG, Gui XQ, Zeng GM, Yuan XZ (2005) A ratiometric fluorescence sensor with broad dynamic range based on two pH-sensitive fluorophores. Analyst 130:1551–1556

    Article  CAS  PubMed  Google Scholar 

  • Niu W, Wei Z, Jia J, Shuang S, Dong C, Yun K (2018) A ratiometric emission NIR-fluorescent probe for sensing and imaging pH changes in live cells. Dyes Pigm 152:155–160

    Article  CAS  Google Scholar 

  • O’Neil EJ, Smith BD (2006) Anion recognition using dimetallic coordination complexes. Coord Chem Rev 250:3068–3080

    Article  Google Scholar 

  • Okamoto S, Eltis LD (2011) The biological occurrence and trafficking of cobalt. Metallomics 3:963–970

    Article  CAS  PubMed  Google Scholar 

  • OrregoHernández J, Nuñez-Dallos N, Portilla J (2016) Recognition of Mg2+ by a New Fluorescent “turn-on” Chemosensor Based on Pyridyl-hydrazono-coumarin. Talanta 152:432–437

    Article  PubMed  Google Scholar 

  • Pal R, Parker D (2007) A single component ratiometric pH probe with long wavelength excitation of europium emission. Chem Commun:474–476

    Google Scholar 

  • Pamei M, Puzari A (2019) Luminescent transition metal–organic frameworks: An emerging sensor for detecting biologically essential metal ions. Nano-Struct Nano-Objects 19:100364

    Article  CAS  Google Scholar 

  • Park J, Yu H, Park S-H, Lee K-H (2020a) Selective ratiometric red-emission detection of In 3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent. Analyst 145:4031–4040

    Article  CAS  PubMed  Google Scholar 

  • Park S-H, Kwon N, Lee J-H, Yoon J, Shin I (2020b) Synthetic ratiometric fluorescent probes for detection of ions. Chem Soc Rev 49:143–179

    Article  CAS  PubMed  Google Scholar 

  • Parr ZS, Nielsen CB (2020) Conjugated molecules for colourimetric and fluorimetric sensing of sodium and potassium. Mater Chem Front 4:2370–2377

    Article  CAS  Google Scholar 

  • Peng X, Wu Y, Fan J, Tian M, Han K (2005) Colorimetric and ratiometric fluorescence sensing of fluoride: tuning selectivity in proton transfer. J Org Chem 70:10524–10531

    Article  CAS  PubMed  Google Scholar 

  • Razavi SAA, Morsali A (2020) Metal ion detection using luminescent-MOFs: Principles, strategies and roadmap. Coord Chem Rev 415:213299

    Article  CAS  Google Scholar 

  • Renuga D, Udhayakumari D, Suganya S, Velmathi S (2012) Novel thiophene based colorimetric and fluorescent receptor for selective recognition of fluoride ions. Tetrahedron Lett 53:5068–5070

    Article  CAS  Google Scholar 

  • Rorabacher DB (2004) Electron transfer by copper centers. Chem Rev 104:651–698

    Article  CAS  PubMed  Google Scholar 

  • Roshal A, Grigorovich A, Doroshenko A, Pivovarenko V, Demchenko A (1998) Flavonols and crown-flavonols as metal cation chelators: the different nature of Ba2+ and Mg2+ complexes. J Phys Chem A 102:5907–5914

    Article  CAS  Google Scholar 

  • Roshal A, Grigorovich A, Doroshenko A, Pivovarenko V, Demchenko A (1999) Flavonols as metal-ion chelators: complex formation with Mg2+ and Ba2+ cations in the excited state. J Photochem Photobiol, A 127:89–100

    Article  CAS  Google Scholar 

  • Saleem M, Rafiq M, Hanif M (2017) Organic material based fluorescent sensor for Hg 2+: a brief review on recent development. J Fluoresc 27:31–58

    Article  CAS  PubMed  Google Scholar 

  • Saleem M, Rafiq M, Hanif M, Shaheen MA, Seo S-Y (2018) A brief review on fluorescent copper sensor based on conjugated organic dyes. J Fluoresc 28:97–165

    Article  PubMed  Google Scholar 

  • Santra M, Roy B, Ahn KH (2011) A “reactive” ratiometric fluorescent probe for mercury species. Org Lett 13:3422–3425

    Article  CAS  PubMed  Google Scholar 

  • Schwarze T, Riemer J, Müller H, John L, Holdt HJ, Wessig P (2019) Na+ selective fluorescent tools based on fluorescence intensity enhancements, lifetime changes, and on a ratiometric response. Chemistry (weinheim an Der Bergstrasse, Germany) 25:12412

    CAS  PubMed  Google Scholar 

  • Sedgwick AC, Wu L, Han H-H, Bull SD, He X-P, James TD, Sessler JL, Tang BZ, Tian H, Yoon J (2018) Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents. Chem Soc Rev 47:8842–8880

    Article  CAS  PubMed  Google Scholar 

  • Shamsipur M, Barati A, Nematifar Z (2019) Fluorescent pH nanosensors: design strategies and applications. J Photochem Photobiol, C 39:76–141

    Article  CAS  Google Scholar 

  • Shanmugapriya J, Singaravadivel S, Sivaraman G, Chellappa D (2018) Anthracene-based highly selective and sensitive fluorescent “turn-on” chemodosimeter for Hg2+. ACS Omega 3:12341

    Article  PubMed  PubMed Central  Google Scholar 

  • Singh N, Kaur N, Mulrooney RC, Callan JF (2008) A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer. Tetrahedron Lett 49:6690–6692

    Article  CAS  Google Scholar 

  • Sinn S, Biedermann F, Vishe M, Aliprandi A, Besnard C, Lacour J, De Cola L (2016) A ratiometric luminescent switch based on platinum complexes tethered to a Crown-Ether Scaffold. ChemPhysChem 17:1829–1834

    Article  CAS  PubMed  Google Scholar 

  • Steinegger A, Wolfbeis OS, Borisov SM (2020) Optical sensing and imaging of pH values: spectroscopies, materials, and applications. Chem Rev 120:12357–12489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun T, Gao Y, Du Y, Zhou L, Chen X (2020) Recent advances in develo** lanthanide metal–organic frameworks for ratiometric fluorescent sensing. Front Chem 8:624592

    Google Scholar 

  • Sun X, Wang Y, Deng X, Zhang J, Zhang Z (2016) A colorimetric and ratiometric fluorescent probe for the selective detection of cyanide anions in aqueous media and living cells. RSC Adv 6:10266–10271

    Article  CAS  Google Scholar 

  • Suzuki Y, Yokoyama K (2015) Development of functional fluorescent molecular probes for the detection of biological substances. Biosensors 5:337–363

    Article  PubMed  PubMed Central  Google Scholar 

  • Szmacinski H, Lakowicz JR (1997) Sodium green as a potential probe for intracellular sodium imaging based on fluorescence lifetime. Anal Biochem 250:131–138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Szumna A, Jurczak J (2001) A new macrocyclic polylactam-type neutral receptor for anions—structural aspects of anion recognition. Eur J Org Chem 2001:4031–4039

    Article  Google Scholar 

  • Taki M, Ogasawara H, Osaki H, Fukazawa A, Sato Y, Ogasawara K, Higashiyama T, Yamaguchi S (2015) A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions. Chem Commun 51:11880–11883

    Article  CAS  Google Scholar 

  • Tantama M, Hung YP, Yellen G (2011) Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor. J Am Chem Soc 133:10034–10037

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tian Z-N, Wu D-Q, Sun X-J, Liu T-T, **ng Z-Y (2019) A benzothiazole-based fluorescent probe for ratiometric detection of Al3+ and its application in water samples and cell imaging. Int J Mol Sci 20:5993

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Udhayakumari D, Velmathi S, Sung Y-M, Wu S-P (2014) Highly fluorescent probe for copper (II) ion based on commercially available compounds and live cell imaging. Sens Actuators, B Chem 198:285–293

    Article  CAS  Google Scholar 

  • Valeur B, Berberan-Santos MN (2012) Molecular fluorescence: principles and applications, 2nd edn. Wiley-VCH, Weinheim, Germany

    Google Scholar 

  • Valuk VR, Duportail G, Pivovarenko VG (2005) A wide-range fluorescent pH-indicator based on 3-hydroxyflavone structure. J Photochem Photobiol Chem 175:226–231

    Article  CAS  Google Scholar 

  • Villemin E, Raccurt O (2021) Optical lithium sensors. Coord Chem Rev 435:213801

    Article  CAS  Google Scholar 

  • Wang L, Bing Q, Li J, Wang G (2018) A new “ON-OFF” fluorescent and colorimetric chemosensor based on 1, 3, 4-oxadiazole derivative for the detection of Cu2+ ions. J Photochem Photobiol, A 360:86–94

    Article  Google Scholar 

  • Wang Z, Detomasi TC, Chang CJ (2021) A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chem Sci 12.5:1720–1729

    Google Scholar 

  • Warrier SB, Kharkar PS (2018) A coumarin based chemosensor for selective determination of Cu (II) ions based on fluorescence quenching. J Lumin 199:407–415

    Article  CAS  Google Scholar 

  • Wencel D, Abel T, McDonagh C (2014) Optical chemical pH sensors. Anal Chem 86:15–29

    Article  CAS  PubMed  Google Scholar 

  • Whitaker JE, Haugland RP, Prendergast FG (1991) Spectral and photophysical studies of benzo[c]xanthene dyes: dual emission pH sensors. Anal Biochem 194:330–344

    Article  CAS  PubMed  Google Scholar 

  • Wu X, Wang H, Yang S, Tian H, Liu Y, Sun B (2019) Highly sensitive ratiometric fluorescent paper sensors for the detection of fluoride ions. ACS Omega 4:4918–4926

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu X, Zhang Z, Liu H, Pu S (2020) A highly selective multi-responsive fluorescence sensor for Zn 2+ based on a diarylethene with a 4, 6-dimethylpyrimidine unit. RSC Adv 10:15547–15553

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • **a S, Shen J, Wang J, Wang H, Fang M, Zhou H, Tanasova M (2018) Ratiometric fluorescent and colorimetric BODIPY-based sensor for zinc ions in solution and living cells. Sens Actuators, B Chem 258:1279–1286

    Article  CAS  Google Scholar 

  • Xu Z, Chen X, Kim HN, Yoon J (2010) Sensors for the optical detection of cyanide ion. Chem Soc Rev 39:127–137

    Article  CAS  PubMed  Google Scholar 

  • Xu Z, Qian X, Cui J (2005) Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu (II)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore. Org Lett 7:3029–3032

    Article  CAS  PubMed  Google Scholar 

  • Yang R, Li K, Wang K, Zhao F, Li N, Liu F (2003) Porphyrin assembly on β-cyclodextrin for selective sensing and detection of a zinc ion based on the dual emission fluorescence ratio. Anal Chem 75:612–621

    Article  CAS  PubMed  Google Scholar 

  • Yang Y, Zhao Q, Feng W, Li F (2013) Luminescent chemodosimeters for bioimaging. Chem Rev 113:192–270

    Article  CAS  PubMed  Google Scholar 

  • Yang Z-R, Wang M-M, Wang X-S, Yin X-B (2017) Boric-acid-functional lanthanide metal–organic frameworks for selective ratiometric fluorescence detection of fluoride ions. Anal Chem 89:1930–1936

    Article  CAS  PubMed  Google Scholar 

  • Yao S, Schafer-Hales KJ, Belfield KD (2007) A new water-soluble near-neutral ratiometric fluorescent pH indicator. Org Lett 9:5645–5648

    Article  CAS  PubMed  Google Scholar 

  • Yao ZQ, Li GY, Xu J, Hu TL, Bu XH (2018) A water‐stable luminescent znii metal‐organic framework as chemosensor for high‐efficiency detection of CrVI‐anions (Cr2O72−and CrO42−) in aqueous solution. Chem Eur J 24: 3192–3198

    Google Scholar 

  • Yu Y, Sheng W, Liu C, Gao N, Tian B, Zhu H, Jia P, Li Z, Zhang X, Wang K (2021) A simple sensitive ratiometric fluorescent probe for the detection of mercury ions in living cells and zebrafish. Spectrochim Acta Part A Mol Biomol Spectrosc 249:119279

    Article  CAS  Google Scholar 

  • Zajac M, Chakraborty K, Saha S, Mahadevan V, Infield DT, Accardi A, Qiu Z, Krishnan Y (2020) What biologists want from their chloride reporters–a conversation between chemists and biologists. J Cell Sci 133

    Google Scholar 

  • Zhang J, Cheng F, Li J, Zhu J-J, Lu Y (2016a) Fluorescent nanoprobes for sensing and imaging of metal ions: Recent advances and future perspectives. Nano Today 11:309–329

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang W-J, Fan L, Li Z-B, Ou T, Zhai H-J, Yang J, Dong C, Shuang S-M (2016b) Thiazole-based ratiometric fluorescence pH probe with large Stokes shift for intracellular imaging. Sens Actuators, B Chem 233:566–573

    Article  CAS  Google Scholar 

  • Zhao J, Yang D, Yang X-J, Wu B (2019a) Anion coordination chemistry: From recognition to supramolecular assembly. Coord Chem Rev 378:415–444

    Article  CAS  Google Scholar 

  • Zhao Y, Wang X, Mi J, Jiang Y, Wang C (2019b) Metal Nanoclusters-Based Ratiometric Fluorescent Probes from Design to Sensing Applications. Part Part Syst Charact 36:1900298

    Article  CAS  Google Scholar 

  • Zhou W, Saran R, Liu J (2017) Metal sensing by DNA. Chem Rev 117:8272–8325

    Article  CAS  PubMed  Google Scholar 

  • Zhou Y, Zhang JF, Yoon J (2014) Fluorescence and colorimetric chemosensors for fluoride-ion detection. Chem Rev 114:5511–5571

    Article  CAS  PubMed  Google Scholar 

  • Zhu M, Yuan M, Liu X, Xu J, Lv J, Huang C, Liu H, Li Y, Wang S, Zhu D (2008) Visible near-infrared chemosensor for mercury ion. Org Lett 10:1481–1484

    Article  CAS  PubMed  Google Scholar 

  • Zhu Q, Li L, Mu L, Zeng X, Redshaw C, Wei G (2016) A ratiometric Al3+ ion probe based on the coumarin-quinoline FRET system. J Photochem Photobiol A 328:217–224

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Demchenko, A.P. (2023). Quantitative Fluorescent Detection of Ions. In: Introduction to Fluorescence Sensing. Springer, Cham. https://doi.org/10.1007/978-3-031-19089-6_9

Download citation

Publish with us

Policies and ethics

Navigation