Environmental Deterioration Due to Existing and Emerging Persistent Organic Pollutants: An Overview

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Organic Pollutants

Abstract

Due to increase in industrialization and rapid civilization, excessive numbers of chemicals are being discharged into the atmosphere. Persistent organic pollutants (POPs) are worldwide concern due to their widespread occurrence, enhanced persistence, distant transference, greater biomagnification and bioaccumulation which could affect the human health and other organisms in the ecosystems. Organic pollutants accumulating in aquatic sediments can adversely affect the benthic organisms, and the same can be thrown back into the ecosystem during resuspension and/or through the food chain from benthic to pelagic organisms and so on. This chapter summarizes the recent findings on the impact of existing and emerging POPs on ecosystem and various organisms including human. In recent years, some of the emerging contaminants including polybrominated diphenyl ethers (PBDEs) and perfluorooctane sulfonate (PFOS) are classified under POPs, and these contaminants have been widely reported in environment. Though the concentrations of emerging POPs in the environment are presently very low, it has been estimated that they would dramatically increase owing to social and economic development. The impact of these pollutants on humans varies from skin rashes to cancer. Congenital disorders and metabolic diseases due to POPs could have significant health impacts for future generations as well. This chapter also addresses studies looking at the relations between the exposure and consequences of POPs to human health emphasizing the impact of these pollutants with reference to their gender-specific effects. This chapter also reviews a wide array of methods which can be used as markers to identify the effect of persistent pollutants on different organisms. Biomagnification and bioaccumulation were used as a tool for revealing the impact on the aquatic systems. Overall, studies in this field relating to POPs are not abundant, and hence extensive studies need to be conducted to increase our understanding on the health and ecological consequences of these contaminants in order to devise strategies for not only preventing exposure but also for ecological remediation.

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References

  • Abdullahi, I., Leonard, H., Cherian, S., Mutch, R., Glasson, E., Klerk, N., et al. (2017). The risk of neurodevelopmental disabilities in children of immigrant and refugee parents: Current knowledge and directions for future research. Review Journal of Autism and Developmental Disorders, 5, 29.

    Article  Google Scholar 

  • Ahmed, O. M., El-Gareib, A. W., El-bakry, A. M., Abd El-Tawab, S. M., & Ahmed, R. G. (2008). Thyroid hormones states and brain development interactions. International Journal of Developmental Neuroscience, 26, 147–209.

    Article  CAS  Google Scholar 

  • Aljerf, L., & Al Masri, N. (2018). Persistence and bioaccumulation of persistent organic pollutants (pops) in the soil and aquatic ecosystems: Syrian frontiers in ecology and environment. Sustainability in Environment, 3, 358–386.

    Article  Google Scholar 

  • Allen, J. G., Gale, S., Zoeller, R. T., Spengler, J. D., Birnbaum, L., & McNeely, E. (2016). Pbde flame retardants, thyroid disease, and menopausal status in U.S. Women. Environmental Health, 15, 60.

    Article  Google Scholar 

  • Alonso-Magdalena, P., Quesada, I., & Nadal, A. (2011). Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nature Reviews Endocrinology, 7, 346–353.

    Article  CAS  Google Scholar 

  • An, J., Chen, C., Wang, X., Zhong, Y., Zhang, X., Yu, Y., et al. (2014). Oligomeric proanthocyanidins alleviate hexabromocyclododecane-induced cytotoxicity in hepg2 cells through regulation on ROS formation and mitochondrial pathway. Toxicology In Vitro, 28, 319–326.

    Article  CAS  Google Scholar 

  • Ao, J., Yuan, T., **a, H., Ma, Y., Shen, Z., Shi, R., et al. (2019). Characteristic and human exposure risk assessment of per- and polyfluoroalkyl substances: A study based on indoor dust and drinking water in China. Environmental Pollution, 254, 112873.

    Article  CAS  Google Scholar 

  • Arkoosh, M., Casillas, E., Clemons, E., Kagley, A., Olson, R., Reno, P., et al. (1998). Effect of pollution on fish diseases: Potential impacts on salmonid populations. Journal of Aquatic Animal Health, 10, 182–190.

    Article  Google Scholar 

  • Ashraf, M. A. (2017). Persistent organic pollutants (pops): A global issue, a global challenge. Springer.

    Google Scholar 

  • ATSDR. (2000). Toxicological profile for endosulfan. Atlanta: Agency of Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/tp41.html

    Google Scholar 

  • Baccarelli, A., Mocarelli, P., Patterson, D. G., Bonzini, M., Pesatori, A. C., Caporaso, N., et al. (2002). Immunologic effects of dioxin: New results from seveso and comparison with other studies. Environmental Health Perspectives, 110, 1169–1173.

    Article  CAS  Google Scholar 

  • Baccarelli, A., Pesatori, A. C., Masten, S. A., Patterson, D. G., Needham, L. L., Mocarelli, P., et al. (2004). Aryl-hydrocarbon receptor-dependent pathway and toxic effects of tcdd in humans: A population-based study in seveso, Italy. Toxicology Letters, 149, 287–293.

    Article  CAS  Google Scholar 

  • Baccarelli, A., Hirt, C., Pesatori, A. C., Consonni, D., Patterson, D. G., Jr., Bertazzi, P. A., et al. (2006). T(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from seveso, Italy. Carcinogenesis, 27, 2001–2007.

    Article  CAS  Google Scholar 

  • Baccarelli, A., Giacomini, S. M., Corbetta, C., Landi, M. T., Bonzini, M., Consonni, D., et al. (2008). Neonatal thyroid function in seveso 25 years after maternal exposure to dioxin. PLoS Medicine, 5, e161.

    Article  Google Scholar 

  • Bach, C. C., Bech, B. H., Brix, N., Nohr, E. A., Bonde, J. P. E., & Henriksen, T. B. (2015). Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review. Critical Reviews in Toxicology, 45, 53–67.

    Article  CAS  Google Scholar 

  • Basu, N. (2012). Piscivorous mammalian wildlife as sentinels of methylmercury exposure and neurotoxicity in humans. In S. Ceccatelli & M. Aschner (Eds.), Methylmercury and neurotoxicity (pp. 357–370). Boston: Springer US.

    Chapter  Google Scholar 

  • Basu, N. (2015). Applications and implications of neurochemical biomarkers in environmental toxicology. Environmental Toxicology and Chemistry, 34, 22–29.

    Article  CAS  Google Scholar 

  • Bergman, Å., Heindel, J. J., Jobling, S., Kidd, K., & Zoeller, T. R. (2013). State of the science of endocrine disrupting chemicals – 2012. United Nations Environment Programme/World Health Organization. http://apps.who.int/iris/bitstream/10665/78102/1/WHO_HSE_PHE_IHE_2013.1_eng.pdf/

    Google Scholar 

  • Beszterda, M., & Franski, R. (2018). Endocrine disruptor compounds in environment: As a danger for children health. Pediatric Endocrinology, Diabetes & Metabolism, 24, 88–95.

    Article  Google Scholar 

  • Betts, K. (2013). Exposure to tdcpp appears widespread. Environmental Health Perspectives, 121, 150.

    Article  Google Scholar 

  • Bonde, J., Flachs, E., Rimborg, S., Glazer, C., Giwercman, A., Ch, R.-H., et al. (2016). The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: A systematic review and meta-analysis. Human Reproduction Update, 23, 104.

    Article  Google Scholar 

  • Boucher, B. A., Ennis, J. K., Tsirlin, D., & Harris, S. A. (2018). A global database of polybrominated diphenyl ether flame retardant congeners in foods and supplements. Journal of Food Composition and Analysis, 69, 171–188.

    Article  CAS  Google Scholar 

  • Bourgeon, S., Riemer, A. K., Tartu, S., Aars, J., Polder, A., Jenssen, B. M., et al. (2017). Potentiation of ecological factors on the disruption of thyroid hormones by organo-halogenated contaminants in female polar bears (ursus maritimus) from the barents sea. Environmental Research, 158, 94–104.

    Article  CAS  Google Scholar 

  • Buccini, J. (2003). The development of a global treaty on persistent organic pollutants (pops). In H. Fiedler (Ed.), Persistent organic pollutants (pp. 13–30). Berlin, Heidelberg: Springer Berlin Heidelberg.

    Chapter  Google Scholar 

  • Burns, J. S., Lee, M. M., Williams, P. L., Korrick, S. A., Sergeyev, O., Lam, T., et al. (2016). Associations of peripubertal serum dioxin and polychlorinated biphenyl concentrations with pubertal timing among russian boys. Environmental Health Perspectives, 124, 1801–1807.

    Article  Google Scholar 

  • Calvert, G. M., Sweeney, M. H., Deddens, J., & Wall, D. K. (1999). Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Occupational and Environmental Medicine, 56, 270.

    Article  CAS  Google Scholar 

  • Cameron, H. L., & Foster, W. G. (2009). Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in her2/neu transgenic mice. PLoS One, 4, e4303.

    Article  Google Scholar 

  • Cano-Sancho, G., Ploteau, S., Matta, K., Adoamnei, E., Louis, G. B., Mendiola, J., et al. (2019). Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta-analysis. Environment International, 123, 209–223.

    Article  CAS  Google Scholar 

  • Casati, L., Sendra, R., Colciago, A., Negri-Cesi, P., Berdasco, M., Esteller, M., et al. (2012). Polychlorinated biphenyls affect histone modification pattern in early development of rats: A role for androgen receptor-dependent modulation? Epigenomics, 4, 101–112.

    Article  CAS  Google Scholar 

  • Caudle, W., Richardson, J., Delea, K., Guillot, T., Wang, M., Pennell, K., et al. (2006). Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to parkinson's disease-associated dopamine toxicity. Toxicological Sciences: an Official Journal of the Society of Toxicology, 92, 490–499.

    Article  CAS  Google Scholar 

  • Chang, J.-W., Chen, H.-L., Su, H.-J., Liao, P.-C., Guo, H.-R., & Lee, C.-C. (2011). Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance. Journal of Hazardous Materials, 185, 749–755.

    Article  CAS  Google Scholar 

  • Chen, C., Wang, T., Khim, J. S., Luo, W., Jiao, W., Lu, Y., et al. (2011). Perfluorinated compounds in water and sediment from coastal regions of the northern bohai sea, China. Chemistry and Ecology, 27, 165–176.

    Article  CAS  Google Scholar 

  • Chen, S.-J., Feng, A.-H., He, M.-J., Chen, M.-Y., Luo, X.-J., & Mai, B.-X. (2012). Current levels and composition profiles of pbdes and alternative flame retardants in surface sediments from the pearl river delta, southern China: Comparison with historical data. The Science of the Total Environment, 444C, 205–211.

    Google Scholar 

  • Chen, N., Li, J., Li, D., Yang, Y., & He, D. (2014a). Chronic exposure to perfluorooctane sulfonate induces behavior defects and neurotoxicity through oxidative damages, in vivo and in vitro. PLoS One, 9, e113453.

    Article  Google Scholar 

  • Chen, Z.-J., Liu, H.-Y., Cheng, Z., Man, Y.-B., Zhang, K.-S., Wei, W., et al. (2014b). Polybrominated diphenyl ethers (pbdes) in human samples of mother–newborn pairs in South China and their placental transfer characteristics. Environment International, 73, 77–84.

    Article  CAS  Google Scholar 

  • Chen, J., Hu, Y., Cai, A., Cheng, T., Wu, Z., Liu, H., et al. (2018). The mesopore-elimination treatment and silanol-groups recovery for macroporous silica microspheres and its application as an efficient support for polystyrene hydrogenation. Catalysis Communications, 111, 75–79.

    Article  CAS  Google Scholar 

  • Ciesielski, T. M., Hansen, I. T., Bytingsvik, J., Hansen, M., Lie, E., Aars, J., et al. (2017). Relationships between pops, biometrics and circulating steroids in male polar bears (ursus maritimus) from svalbard. Environmental Pollution, 230, 598–608.

    Article  CAS  Google Scholar 

  • Corsini, E., Luebke, R. W., Germolec, D. R., & DeWitt, J. C. (2014). Perfluorinated compounds: Emerging pops with potential immunotoxicity. Toxicology Letters, 230, 263–270.

    Article  CAS  Google Scholar 

  • Costa, L. G., & Giordano, G. (2007). Developmental neurotoxicity of polybrominated diphenyl ether (pbde) flame retardants. Neurotoxicology, 28, 1047–1067.

    Article  CAS  Google Scholar 

  • Covaci, A., Harrad, S., Abdallah, M. A. E., Ali, N., Law, R. J., Herzke, D., et al. (2011). Novel brominated flame retardants: A review of their analysis, environmental fate and behaviour. Environment International, 37, 532–556.

    Article  CAS  Google Scholar 

  • Dai, Q., Xu, X., Eskenazi, B., Asante, K. A., Chen, A., Fobil, J., et al. (2020). Severe dioxin-like compound (dlc) contamination in e-waste recycling areas: An under-recognized threat to local health. Environment International, 139, 105731.

    Article  CAS  Google Scholar 

  • Darnerud, P. O. (2008). Brominated flame retardants as possible endocrine disrupters. International Journal of Andrology, 31, 152–160.

    Article  CAS  Google Scholar 

  • de Boer, J., Ballesteros-Gómez, A., Leslie, H. A., Brandsma, S. H., & Leonards, P. E. G. (2016). Flame retardants: Dust – and not food – might be the risk. Chemosphere, 150, 461–464.

    Article  Google Scholar 

  • Deng, J., Liu, C., Yu, L., & Zhou, B. (2010). Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction. Toxicology and Applied Pharmacology, 243, 87–95.

    Article  CAS  Google Scholar 

  • Desaulniers, D., **ao, G.-H., Lian, H., Feng, Y.-L., Zhu, J., Nakai, J., et al. (2009). Effects of mixtures of polychlorinated biphenyls, methylmercury, and organochlorine pesticides on hepatic DNA methylation in prepubertal female Sprague-dawley rats. International Journal of Toxicology, 28, 294–307.

    Article  CAS  Google Scholar 

  • Desforges, J.-P. W., Sonne, C., Levin, M., Siebert, U., De Guise, S., & Dietz, R. (2016). Immunotoxic effects of environmental pollutants in marine mammals. Environment International, 86, 126–139.

    Article  CAS  Google Scholar 

  • Deshpande, A. D., Dickhut, R. M., Dockum, B. W., Brill, R. W., & Farrington, C. (2016). Polychlorinated biphenyls and organochlorine pesticides as intrinsic tracer tags of foraging grounds of bluefin tuna in the Northwest Atlantic Ocean. Marine Pollution Bulletin, 105, 265–276.

    Article  CAS  Google Scholar 

  • Devi, N. L. (2020). Persistent organic pollutants (pops): Environmental risks, toxicological effects, and bioremediation for environmental safety and challenges for future research. In G. Saxena & R. N. Bharagava (Eds.), Bioremediation of industrial waste for environmental safety: Volume i: Industrial waste and its management (pp. 53–76). Singapore: Springer Singapore.

    Chapter  Google Scholar 

  • Dietert, R. R. (2014). Chapter 18 - transgenerational epigenetics of endocrine-disrupting chemicals. In T. Tollefsbol (Ed.), Transgenerational epigenetics (pp. 239–254). Oxford: Academic Press.

    Chapter  Google Scholar 

  • Domingo, J. L., Jogsten, I. E., Eriksson, U., Martorell, I., Perelló, G., Nadal, M., et al. (2012). Human dietary exposure to perfluoroalkyl substances in catalonia, Spain. Temporal trend. Food Chemistry, 135, 1575–1582.

    Article  CAS  Google Scholar 

  • Drottar, K. R., MacGregor, J. A., & Krueger, H. O. (2001). Hexabromocyclododecane (HBCD): An early life-stage toxicity test with the rainbow trout (Oncorhynchus mykiss). Final report. Wildlife International, Ltd., Easton, Maryland, USA. p. 102.

    Google Scholar 

  • Eriksson, P., Viberg, H., Fischer, C., Wallin, M., & Fredriksson, A. (2002). A comparison on developmental neurotoxic effects of hexabromocyclododecane, 2,2′,4,4′,5,5′-hexabromodiphenylether (pbde 153) and 2,2′,4,4′,5,5′-hexachlorobiphenyl (pcb 153). Organohalogen Compounds, 57, 389–392.

    CAS  Google Scholar 

  • Eskenazi, B., Warner, M., Marks, A. R., Samuels, S., Needham, L., Brambilla, P., et al. (2010). Serum dioxin concentrations and time to pregnancy. Epidemiology, 21, 224–231.

    Article  Google Scholar 

  • Fang, C., Huang, Q., Ye, T., Chen, Y., Liu, L., Kang, M., et al. (2013). Embryonic exposure to pfos induces immunosuppression in the fish larvae of marine medaka. Ecotoxicology and Environmental Safety, 92, 104–111.

    Article  CAS  Google Scholar 

  • Fernie, K. J., Shutt, J. L., Mayne, G., Hoffman, D., Letcher, R. J., Drouillard, K. G., et al. (2005). Exposure to polybrominated diphenyl ethers (pbdes): Changes in thyroid, vitamin a, glutathione homeostasis, and oxidative stress in american kestrels (falco sparverius). Toxicological Sciences, 88, 375–383.

    Article  CAS  Google Scholar 

  • Filgo, A. J., Quist, E. M., Hoenerhoff, M. J., Brix, A. E., Kissling, G. E., & Fenton, S. E. (2015). Perfluorooctanoic acid (pfoa)–induced liver lesions in two strains of mice following developmental exposures:Pparα is not required. Toxicologic Pathology, 43, 558–568.

    Article  CAS  Google Scholar 

  • Fremlin, K. (2018). Trophic magnification of legacy persistent organic pollutants and emergent contaminants within a terrestrial food-web of an avian apex predator, the Cooper’s Hawk (Accipiter cooperii). Simon Fraser University. Master of Science, Biological Sciences.

    Google Scholar 

  • Fuentes, S., Vicens, P., Colomina, T., & Domingo, J. (2008). Behavioral effects in adult mice exposed to perfluorooctane sulfonate (pfos). Toxicology, 242, 123–129.

    Article  Google Scholar 

  • Gallo, V., Leonardi, G., Genser, B., Lopez-Espinosa, M.-J., Frisbee, S. J., Karlsson, L., et al. (2012). Serum perfluorooctanoate (pfoa) and perfluorooctane sulfonate (pfos) concentrations and liver function biomarkers in a population with elevated pfoa exposure. Environmental Health Perspectives, 120, 655–660.

    Article  CAS  Google Scholar 

  • Geyer, H. J., Schramm, K. W., Darnerud, P. O., Aune, M., Anton Feicht, E., Fried, K. W., Henkelmann, B., Lenoir, D., Schmid, P., & McDonald, T. A. (2004). Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans. Organohalogen Compounds, 66, 3867–3872.

    Google Scholar 

  • Gezer, A. O., Kochmanski, J., VanOeveren, S. E., Cole-Strauss, A., Kemp, C. J., Patterson, J. R., et al. (2020). Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits. Neurobiology of Disease, 141, 104947.

    Article  CAS  Google Scholar 

  • Giannandrea, F., Gandini, L., Paoli, D., Turci, R., & Figà-Talamanca, I. (2011). Pesticides exposure a serum organochlorine residuals among testicular cancer patients and heathy controls. Journal of Environmental Science and Health Part B, Pesticides, Food Contaminants, and Agricultural Wastes, 46, 780–787.

    CAS  Google Scholar 

  • Giesy, J. P., & Kannan, K. (1998). Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (pcbs): Implications for risk assessment. Critical Reviews in Toxicology, 28, 511–569.

    Article  CAS  Google Scholar 

  • Giesy, J. P., & Kannan, K. (2002). Perfluorochemical surfactants in the environment. These bioaccumulative compounds occur globally, warranting further study. Environmental Science & Technology, 36(7), 146A–152A.

    Google Scholar 

  • Giesy, J. P., Jones, P. D., Kannan, K., Newsted, J. L., Tillitt, D. E., & Williams, L. L. (2002). Effects of chronic dietary exposure to environmentally relevant concentrations to 2,3,7,8-tetrachlorodibenzo-p-dioxin on survival, growth, reproduction and biochemical responses of female rainbow trout (oncorhynchus mykiss). Aquatic Toxicology, 59, 35–53.

    Article  CAS  Google Scholar 

  • Gobas, F. A., Burkhard, L. P., Doucette, W. J., Sap**ton, K. G., Verbruggen, E. M., Hope, B. K., et al. (2016). Review of existing terrestrial bioaccumulation models and terrestrial bioaccumulation modeling needs for organic chemicals. Integrated Environmental Assessment and Management, 12, 123–134.

    Article  CAS  Google Scholar 

  • Good, T. P., Pearson, S. F., Hodum, P., Boyd, D., Anulacion, B. F., & Ylitalo, G. M. (2014). Persistent organic pollutants in forage fish prey of rhinoceros auklets breeding in puget sound and the northern California current. Marine Pollution Bulletin, 86, 367–378.

    Article  CAS  Google Scholar 

  • Gopalakrishnan, S., Huang, W.-B., Wang, Q.-W., Wu, M.-L., Liu, J., & Wang, K.-J. (2011). Effects of tributyltin and benzo[a]pyrene on the immune-associated activities of hemocytes and recovery responses in the gastropod abalone, haliotis diversicolor. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 154, 120–128.

    Google Scholar 

  • Haave, M., Ropstad, E., Derocher, A., Lie, E., Dahl, E., Wiig, Ø., et al. (2003). Polychlorinated biphenyls and reproductive hormones in female polar bears at svalbard. Environmental Health Perspectives, 111, 431–436.

    Article  CAS  Google Scholar 

  • Hagenaars, A., Knapen, D., Meyer, I. J., van der Ven, K., Hoff, P., & De Coen, W. (2008). Toxicity evaluation of perfluorooctane sulfonate (pfos) in the liver of common carp (cyprinus carpio). Aquatic Toxicology, 88, 155–163.

    Article  CAS  Google Scholar 

  • Haijima, A., Endo, T., Zhang, Y., Miyazaki, W., Kakeyama, M., & Tohyama, C. (2010). In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice. Neurotoxicology, 31, 385–390.

    Article  CAS  Google Scholar 

  • Hansen, K. E. A., Johanson, S. M., Steppeler, C., Sødring, M., Østby, G. C., Berntsen, H. F., et al. (2019). A mixture of persistent organic pollutants (pops) and azoxymethane (aom) show potential synergistic effects on intestinal tumorigenesis in the a/j min/+ mouse model. Chemosphere, 214, 534–542.

    Article  CAS  Google Scholar 

  • Hatcher-Martin, J., Gearing, M., Steenland, K., Levey, A., Miller, G., & Pennell, K. (2012). Association between polychlorinated biphenyls and parkinson's disease neuropathology. Neurotoxicology, 33, 1298–1304.

    Article  CAS  Google Scholar 

  • Hill, A., Howard, C. V., Strahle, U., & Cossins, A. (2003). Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrations. Toxicological Sciences, 76, 392–399.

    Article  CAS  Google Scholar 

  • Hsu, P.-C., Guo, Y. L., & Li, M.-H. (2004). Effects of acute postnatal exposure to 3,3′,4,4′-tetrachlorobiphenyl on sperm function and hormone levels in adult rats. Chemosphere, 54, 611–618.

    Article  CAS  Google Scholar 

  • IARC. (2016). International Agency for Research on Cancer (IARC), 2016. Monographs on the evaluation of carcinogenic risks to humans (Vol. 107. Polychlorinated biphenyls and polybrominated biphenyls. World Health Organization). Lyon: International Agency for Research on Cancer.

    Google Scholar 

  • Imaeda, D., Nomiyama, K., Kunisue, T., Iwata, H., Tsydenova, O., Amano, M., et al. (2014). Blood levels of polychlorinated biphenyls and their hydroxylated metabolites in baikal seals (pusa sibirica): Emphasis on interspecies comparison, gender difference and association with blood thyroid hormone levels. Chemosphere, 114, 1–8.

    Article  CAS  Google Scholar 

  • Jensen, S. (1966). Report of a new chemical hazard. New Scientist, 32, 612.

    Google Scholar 

  • Jenssen, B. M. (2006). Endocrine-disrupting chemicals and climate change: A worst-case combination for arctic marine mammals and seabirds? Environmental Health Perspectives, 114, 76–80.

    Article  Google Scholar 

  • Jepson, P., & Law, R. (2016). Persistent pollutants, persistent threats. Science, 352, 1388–1389.

    Article  CAS  Google Scholar 

  • Jepson, P. D., Deaville, R., Barber, J. L., Aguilar, À., Borrell, A., Murphy, S., et al. (2016). Pcb pollution continues to impact populations of orcas and other dolphins in european waters. Scientific Reports, 6, 18573.

    Article  CAS  Google Scholar 

  • Jiang, L.-G., Cheng, L.-Y., Kong, S.-H., Yang, Y., Shen, Y.-J., Chen, C., et al. (2016). Toxic effects of polychlorinated biphenyls (aroclor 1254) on human sperm motility. Asian Journal of Andrology, 18, 561.

    Google Scholar 

  • Johnson, P. I., Stapleton, H. M., Mukherjee, B., Hauser, R., & Meeker, J. D. (2013). Associations between brominated flame retardants in house dust and hormone levels in men. Science of the Total Environment, 445-446, 177–184.

    Article  CAS  Google Scholar 

  • Kang, J. S., Ahn, T.-G., & Park, J.-W. (2019). Perfluorooctanoic acid (pfoa) and perfluooctane sulfonate (pfos) induce different modes of action in reproduction to japanese medaka (oryzias latipes). Journal of Hazardous Materials, 368, 97–103.

    Article  CAS  Google Scholar 

  • Kataria, A., Trachtman, H., Malaga-Dieguez, L., & Trasande, L. (2015). Association between perfluoroalkyl acids and kidney function in a cross-sectional study of adolescents. Environmental Health, 14, 89.

    Article  Google Scholar 

  • Kato, Y., Haraguchi, K., Yamazaki, T., Ito, Y., Miyajima, S., Nemoto, K., et al. (2003). Effects of polychlorinated biphenyls, kanechlor-500, on serum thyroid hormone levels in rats and mice. Toxicological Sciences, 72, 235–241.

    Article  CAS  Google Scholar 

  • Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., et al. (2004). The toxicology of perfluorooctanoate. Critical Reviews in Toxicology, 34, 351–384.

    Article  CAS  Google Scholar 

  • Kern, P. A., Said, S., Jackson, W. G., Jr., & Michalek, J. E. (2004). Insulin sensitivity following Agent Orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. The Journal of Clinical Endocrinology and Metabolism, 89, 4665–4672.

    Article  CAS  Google Scholar 

  • Khansari, M. R., Yousefsani, B. S., Kobarfard, F., Faizi, M., & Pourahmad, J. (2017). In vitro toxicity of perfluorooctane sulfonate on rat liver hepatocytes: Probability of distructive binding to cyp 2e1 and involvement of cellular proteolysis. Environmental Science and Pollution Research, 24, 23382–23388.

    Article  CAS  Google Scholar 

  • Kim, J.-S., Lim, H.-S., Cho, S.-I., Cheong, H.-K., & Lim, M.-K. (2003). Impact of agent orange exposure among korean Vietnam veterans. Industrial Health, 41, 149–157.

    Article  Google Scholar 

  • Kim, Y.-K., Na, K.-S., Myint, A.-M., & Leonard, B. E. (2016). The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 64, 277–284.

    Article  CAS  Google Scholar 

  • Kim, K.-W., Won, Y. L., & Ogawa, Y. (2018). Associations between blood levels of polychlorinated dibenzo-p-dioxins/furans and polychlorinated biphenyls with immune systems. Toxicology and Environmental Health Sciences, 10, 17–25.

    Article  Google Scholar 

  • Kim, K.-W., Choo, G., Cho, H.-S., Lee, B.-C., Park, K., & Oh, J.-E. (2019). The occurrence and distribution of polychlorinated naphthalenes (pcns), focusing on tissue-specific bioaccumulation in crucian carp in South Korea. Science of the Total Environment, 665, 484–491.

    Article  CAS  Google Scholar 

  • King Heiden, T. C., Spitsbergen, J., Heideman, W., & Peterson, R. E. (2009). Persistent adverse effects on health and reproduction caused by exposure of zebrafish to 2,3,7,8-tetrachlorodibenzo-p-dioxin during early development and gonad differentiation. Toxicological Sciences, 109, 75–87.

    Article  CAS  Google Scholar 

  • Kjeldsen, L. S., & Bonefeld-Jørgensen, E. C. (2013). Perfluorinated compounds affect the function of sex hormone receptors. Environmental Science and Pollution Research, 20, 8031–8044.

    Article  CAS  Google Scholar 

  • Knafl, G. (2018). A reassessment of birth defects for children of participants of the air force health study. Open Journal of Epidemiology, 8, 187–200.

    Article  Google Scholar 

  • Knerr, S., & Schrenk, D. (2006). Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models. Molecular Nutrition & Food Research, 50, 897–907.

    Article  CAS  Google Scholar 

  • Kobayashi, S., Azumi, K., Goudarzi, H., Araki, A., Miyashita, C., Kobayashi, S., et al. (2017). Effects of prenatal perfluoroalkyl acid exposure on cord blood igf2/h19 methylation and ponderal index: The Hokkaido study. Journal of Exposure Science & Environmental Epidemiology, 27, 251–259.

    Article  CAS  Google Scholar 

  • Koual, M., Cano-Sancho, G., Bats, A.-S., Tomkiewicz, C., Kaddouch-Amar, Y., Douay-Hauser, N., et al. (2019). Associations between persistent organic pollutants and risk of breast cancer metastasis. Environment International, 132, 105028.

    Article  CAS  Google Scholar 

  • Kuriyama, S., Wanner, A., Fidalgo-Neto, A., Talsness, C., Koerner, W., & Chahoud, I. (2008). Developmental exposure to low-dose pbde-99: Tissue distribution and thyroid hormone levels. Toxicology, 242, 80–90.

    Article  Google Scholar 

  • Lee, J. W., Lee, J.-W., Kim, K., Shin, Y.-J., Kim, J., Kim, S., et al. (2017). Pfoa-induced metabolism disturbance and multi-generational reproductive toxicity in oryzias latipes. Journal of Hazardous Materials, 340, 231–240.

    Article  CAS  Google Scholar 

  • Lee, Y.-M., Kim, S.-A., Choi, G.-S., Park, S.-Y., Jeon, S. W., Lee, H. S., et al. (2018). Association of colorectal polyps and cancer with low-dose persistent organic pollutants: A case-control study. PLoS One, 13, e0208546.

    Article  CAS  Google Scholar 

  • Legler, J. (2008). New insights into the endocrine disrupting effects of brominated flame retardants. Chemosphere, 73, 216–222.

    Article  CAS  Google Scholar 

  • Lehnert, K., Desforges, J.-P., Das, K., & Siebert, U. (2018). Chapter 10 - ecotoxicological biomarkers and accumulation of contaminants in pinnipeds. In M. C. Fossi & C. Panti (Eds.), Marine mammal ecotoxicology (pp. 261–289). Academic Press.

    Chapter  Google Scholar 

  • Liang, R., He, J., Shi, Y., Li, Z., Sarvajayakesavalu, S., Baninla, Y., et al. (2017). Effects of perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of daphnia magna. Chemosphere, 168, 1613–1618.

    Article  CAS  Google Scholar 

  • Lindberg, P., Sellström, U., Häggberg, L., & de Wit, C. (2004). Higher brominated diphenyl ethers and hexabromocyclododecane found in eggs of peregrine falcons (falco peregrinus) breeding in Sweden. Environmental Science & Technology, 38, 93–96.

    Article  CAS  Google Scholar 

  • Liu, Y., Luo, X., Zeng, Y., Deng, M., Tu, W., Wu, Y., et al. (2020). Bioaccumulation and biomagnification of hexabromocyclododecane (hbcdd) in insect-dominated food webs from a former e-waste recycling site in South China. Chemosphere, 240, 124813.

    Article  CAS  Google Scholar 

  • Long, M., Ghisari, M., & Bonefeld-Jørgensen, E. C. (2013). Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor. Environmental Science and Pollution Research, 20, 8045–8056.

    Article  CAS  Google Scholar 

  • Lv, Q.-Y., Wan, B., Guo, L.-H., Yang, Y., Ren, X.-M., & Zhang, H. (2015). In vivo immunotoxicity of perfluorooctane sulfonate in balb/c mice: Identification of t-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen. Chemico-Biological Interactions, 240, 84–93.

    Article  CAS  Google Scholar 

  • Maisonet, M., Terrell, M. L., McGeehin, M. A., Christensen, K. Y., Holmes, A., Calafat, A. M., et al. (2012). Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in british girls. Environmental Health Perspectives, 120, 1432–1437.

    Article  CAS  Google Scholar 

  • Manikkam, M., Guerrero-Bosagna, C., Tracey, R., Haque, M. M., & Skinner, M. K. (2012). Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures. PLoS One, 7, e31901.

    Article  CAS  Google Scholar 

  • Mariussen, E., & Fonnum, F. (2006). Neurochemical targets and behavioral effects of organohalogen compounds: An update. Critical Reviews in Toxicology, 36, 253–289.

    Article  CAS  Google Scholar 

  • Meeker, J., & Stapleton, H. (2010). House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environmental Health Perspectives, 118, 318–323.

    Article  CAS  Google Scholar 

  • Milon, A., Opydo-Chanek, M., Tworzydlo, W., Galas, J., Pardyak, L., Kaminska, A., et al. (2017). Chlorinated biphenyls effect on estrogen-related receptor expression, steroid secretion, mitochondria ultrastructure but not on mitochondrial membrane potential in leydig cells. Cell and Tissue Research, 369, 429–444.

    Article  CAS  Google Scholar 

  • Miyashita, C., Sasaki, S., Saijo, Y., Washino, N., Okada, E., Kobayashi, S., et al. (2011). Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy. Environmental Research, 111, 551–558.

    Article  CAS  Google Scholar 

  • Miyashita, C., Bamai, Y. A., Araki, A., Itoh, S., Minatoya, M., Kobayashi, S., et al. (2018). Prenatal exposure to dioxin-like compounds is associated with decreased cord blood ige and increased risk of wheezing in children aged up to 7years: The Hokkaido study. Science of the Total Environment, 610-611, 191–199.

    Article  CAS  Google Scholar 

  • Mocarelli, P., Gerthoux, P. M., Patterson, D. G., Milani, S., Limonta, G., Bertona, M., et al. (2008). Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality. Environmental Health Perspectives, 116, 70–77.

    Article  CAS  Google Scholar 

  • Mocarelli, P., Gerthoux, P. M., Needham, L. L., Patterson, D. G., Limonta, G., Falbo, R., et al. (2011). Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environmental Health Perspectives, 119, 713–718.

    Article  CAS  Google Scholar 

  • Morris, A., Muir, D., Solomon, K., Teixeira, C., Duric, M., & Wang, X. (2018). Bioaccumulation of polybrominated diphenyl ethers (pbdes) and alternative halogenated flame retardants in a vegetation-caribou-wolf food chain of the Canadian arctic. Environmental Science & Technology, 52, 3136.

    Article  CAS  Google Scholar 

  • Muir, D., Bossi, R., Carlsson, P., Evans, M., De Silva, A., Halsall, C., et al. (2019). Levels and trends of poly- and perfluoroalkyl substances in the arctic environment – An update. Emerging Contaminants, 5, 240–271.

    Article  Google Scholar 

  • Neugebauer, J., Wittsiepe, J., Kasper-Sonnenberg, M., Schöneck, N., Schölmerich, A., & Wilhelm, M. (2015). The influence of low level pre- and perinatal exposure to pcdd/fs, pcbs, and lead on attention performance and attention-related behavior among german school-aged children: Results from the Duisburg birth cohort study. International Journal of Hygiene and Environmental Health, 218, 153–162.

    Article  CAS  Google Scholar 

  • Newman, J. W., Becker, J. S., Blondina, G., & Tjeerdema, R. S. (1998). Quantitation of aroclors using congener-specific results. Environmental Toxicology and Chemistry, 17, 2159–2167.

    Article  CAS  Google Scholar 

  • Ngo, A. D., Taylor, R., Roberts, C. L., & Nguyen, T. V. (2006). Association between agent orange and birth defects: Systematic review and meta-analysis. International Journal of Epidemiology, 35, 1220–1230.

    Article  Google Scholar 

  • Nie, Z., Tian, S., Tian, Y., Tang, Z., Tao, Y., Die, Q., et al. (2015). The distribution and biomagnification of higher brominated bdes in terrestrial organisms affected by a typical e-waste burning site in South China. Chemosphere, 118, 301–308.

    Article  CAS  Google Scholar 

  • Noël, M., Loseto, L. L., Helbing, C. C., Veldhoen, N., Dangerfield, N. J., & Ross, P. S. (2014). Pcbs are associated with altered gene transcript profiles in arctic beluga whales (delphinapterus leucas). Environmental Science & Technology, 48, 2942–2951.

    Article  Google Scholar 

  • Nowak, K., Jabłońska, E., & Ratajczak-Wrona, W. (2019). Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells. Environment International, 125, 350–364.

    Article  CAS  Google Scholar 

  • Noyes, P. D., & Stapleton, H. M. (2014). Pbde flame retardants. Endocrine Disruptors, 2, e29430.

    Article  Google Scholar 

  • O’Driscoll, C. A., Owens, L. A., Hoffmann, E. J., Gallo, M. E., Afrazi, A., Han, M., et al. (2019). Ambient urban dust particulate matter reduces pathologic t cells in the cns and severity of eae. Environmental Research, 168, 178–192.

    Article  Google Scholar 

  • O'Neill, S. M., & West, J. E. (2009). Marine distribution, life history traits, and the accumulation of polychlorinated biphenyls in Chinook salmon from puget sound, Washington. Transactions of the American Fisheries Society, 138, 616–632.

    Article  CAS  Google Scholar 

  • Ottinger, M. A., Dean, K., McKernan, M., & Quinn, M. J. (2011). Chapter 9 - endocrine disruption of reproduction in birds. In D. O. Norris & K. H. Lopez (Eds.), Hormones and reproduction of vertebrates (pp. 239–260). London: Academic Press.

    Google Scholar 

  • Palace, V. P., Pleskach, K., Halldorson, T., Danell, R., Wautier, K., Evans, B., et al. (2008). Biotransformation enzymes and thyroid axis disruption in juvenile rainbow trout (oncorhynchus mykiss) exposed to hexabromocyclododecane diastereoisomers. Environmental Science & Technology, 42, 1967–1972.

    Article  CAS  Google Scholar 

  • Peden-Adams, M. M., Keller, J. M., EuDaly, J. G., Berger, J., Gilkeson, G. S., & Keil, D. E. (2008). Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate. Toxicological Sciences, 104, 144–154.

    Article  CAS  Google Scholar 

  • Pelcl, T., Skrha, J., Jr., Prazny, M., Vlckova, S., Fenclova, Z., Navratil, T., et al. (2018). Diabetes, cardiovascular disorders and 2,3,7,8-tetrachlorodibenzo-p-dioxin body burden in czech patients 50 years after the intoxication. Basic & Clinical Pharmacology & Toxicology, 123, 356–359.

    Article  CAS  Google Scholar 

  • Pelclova, D., Fenclova, Z., Urban, P., Ridzon, P., Preiss, J., Kupka, K., Malik, J., Dubska, Z., & Navratil, T. (2009). Chronic health impairment due to 2,3,7,8-tetrachloro-dibenzop- dioxin exposure. Neuro Endocrinology Letters, 30(Suppl 1), 219–224.

    CAS  Google Scholar 

  • Pelclova, D., Urban, P., Fenclova, Z., Vlckova, S., Ridzon, P., Kupka, K., Meckova, Z., Bezdicek, O., Navratil, T., Rosmus, J., & Zakharov, S. (2018). Neurological and neurophysiological findings in workers with chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin intoxication 50 years after exposure. Basic & Clinical Pharmacology & Toxicology, 122, 271–277.

    Article  CAS  Google Scholar 

  • Pesatori, A. C., Consonni, D., Bachetti, S., Zocchetti, C., Bonzini, M., Baccarelli, A., et al. (2003). Short- and long-term morbidity and mortality in the population exposed to dioxin after the “seveso accident”. Industrial Health, 41, 127–138.

    Article  CAS  Google Scholar 

  • Pilsner, J. R., Parker, M., Sergeyev, O., & Suvorov, A. (2017). Spermatogenesis disruption by dioxins: Epigenetic reprograming and windows of susceptibility. Reproductive Toxicology, 69, 221–229.

    Article  CAS  Google Scholar 

  • Pinson, A., Bourguignon, J. P., & Parent, A. S. (2016). Exposure to endocrine disrupting chemicals and neurodevelopmental alterations. Andrology, 4, 706–722.

    Article  CAS  Google Scholar 

  • Reinhardt, K. H., & Wodarg, D. (1988). Transport of selected organochlorine compounds over the sea. Journal of Aerosol Science, 19, 1251–1255.

    Article  CAS  Google Scholar 

  • Revich, B., Aksel, E., Ushakova, T., Ivanova, I., Zhuchenko, N., Klyuev, N., et al. (2001). Dioxin exposure and public health in chapaevsk, Russia. Chemosphere, 43, 951–966.

    Article  CAS  Google Scholar 

  • Ribas-Fitó, N., Sala, M., Kogevinas, M., & Sunyer, J. (2001). Polychlorinated biphenyls (pcbs) and neurological development in children: A systematic review. Journal of Epidemiology and Community Health, 55, 537–546.

    Article  Google Scholar 

  • Rodgers, K. M., Udesky, J. O., Rudel, R. A., & Brody, J. G. (2018). Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms. Environmental Research, 160, 152–182.

    Article  CAS  Google Scholar 

  • Rogstad, T. W., Sonne, C., Villanger, G. D., Ahlstøm, Ø., Fuglei, E., Muir, D. C. G., et al. (2017). Concentrations of vitamin a, e, thyroid and testosterone hormones in blood plasma and tissues from emaciated adult male arctic foxes (vulpes lagopus) dietary exposed to persistent organic pollutants (pops). Environmental Research, 154, 284–290.

    Article  CAS  Google Scholar 

  • Roos, A., Bäcklin, B.-M., Helander, B., Rigét, F., & Eriksson, U. (2012). Improved reproductive success in otters (lutra lutra), grey seals (halichoerus grypus) and sea eagles (haliaeetus albicilla) from Sweden in relation to concentrations of organochlorine contaminants. Environmental Pollution (Barking, Essex : 1987), 170, 268–275.

    Article  CAS  Google Scholar 

  • Rosenberg, D. M., Danks, H. V., & Lehmkuhl, D. M. (1986). Importance of insects in environmental impact assessment. Environmental Management, 10, 773–783.

    Article  Google Scholar 

  • Routti, H., Atwood, T. C., Bechshoft, T., Boltunov, A., Ciesielski, T. M., Desforges, J.-P., et al. (2019). State of knowledge on current exposure, fate and potential health effects of contaminants in polar bears from the circumpolar arctic. Science of the Total Environment, 664, 1063–1083.

    Article  CAS  Google Scholar 

  • Saegusa, Y., Fujimoto, H., Woo, G.-H., Inoue, K., Takahashi, M., Mitsumori, K., et al. (2009). Developmental toxicity of brominated flame retardants, tetrabromobisphenol a and 1,2,5,6,9,10-hexabromocyclododecane, in rat offspring after maternal exposure from mid-gestation through lactation. Reproductive Toxicology, 28, 456–467.

    Article  CAS  Google Scholar 

  • Sanganyado, E., Rajput, I. R., & Liu, W. (2018). Bioaccumulation of organic pollutants in indo-pacific humpback dolphin: A review on current knowledge and future prospects. Environmental Pollution, 237, 111–125.

    Article  CAS  Google Scholar 

  • Segner, H. (2011). Reproductive and developmental toxicity in fishes. In R. C. Gupta (Ed.), Reproductive and developmental toxicology (pp. 1145–1166). Amsterdam: Elsevier.

    Chapter  Google Scholar 

  • Segner, H., Möller, A. M., Wenger, M., & Casanova-Nakayama, A. (2011). Fish immunotoxicology: Research at the crossroads of immunology, ecology and toxicology. In A. Hirawa (Ed.), Interdisciplinary studies in environmental chemistry (Vol. 6, pp. 1–15). Tokyo: Terra Scientific Publishing Company.

    Google Scholar 

  • Sexton, K., & Hattis, D. (2007). Assessing cumulative health risks from exposure to environmental mixtures—Three fundamental questions. Environmental Health Perspectives, 115, 825–832.

    Article  CAS  Google Scholar 

  • Skinner, M. K., Manikkam, M., & Guerrero-Bosagna, C. (2010). Epigenetic transgenerational actions of environmental factors in disease etiology. Trends in Endocrinology & Metabolism, 21, 214–222.

    Article  CAS  Google Scholar 

  • Skinner, M. K., Manikkam, M., & Guerrero-Bosagna, C. (2011). Epigenetic transgenerational actions of endocrine disruptors. Reproductive Toxicology, 31, 337–343.

    Article  CAS  Google Scholar 

  • Song, Y., & Yang, L. (2018). Transgenerational impaired spermatogenesis with sperm h19 and gtl2 hypomethylation induced by the endocrine disruptor p,p’-dde. Toxicology Letters, 297, 34–41.

    Article  CAS  Google Scholar 

  • Song, L., Zhao, J., **, X., Li, Z., Newton, I. P., Liu, W., et al. (2014). The organochlorine p,p′-dichlorodiphenyltrichloroethane induces colorectal cancer growth through wnt/β-catenin signaling. Toxicology Letters, 229, 284–291.

    Article  CAS  Google Scholar 

  • Sonne, C., Siebert, U., Gonnsen, K., Desforges, J.-P., Eulaers, I., Persson, S., et al. (2020). Health effects from contaminant exposure in Baltic Sea birds and marine mammals: A review. Environment International, 139, 105725.

    Article  CAS  Google Scholar 

  • Sonthithai, P., Suriyo, T., Thiantanawat, A., Watcharasit, P., Ruchirawat, M., & Satayavivad, J. (2016). Perfluorinated chemicals, pfos and pfoa, enhance the estrogenic effects of 17β-estradiol in t47d human breast cancer cells. Journal of Applied Toxicology, 36, 790–801.

    Article  CAS  Google Scholar 

  • Spulber, S., Kilian, P., Wan Ibrahim, W. N., Onishchenko, N., Ulhaq, M., Norrgren, L., et al. (2014). Pfos induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae. PLoS One, 9, e94227.

    Article  Google Scholar 

  • Stapleton, H. M., Klosterhaus, S., Keller, A., Ferguson, P. L., van Bergen, S., Cooper, E., et al. (2011). Identification of flame retardants in polyurethane foam collected from baby products. Environmental Science & Technology, 45, 5323–5331.

    Article  CAS  Google Scholar 

  • Stegeman, J. J., & Hahn, M. E. (1994). Biochemistry and molecular biology of monooxygenase: Current perspective on forms, functions, and regulation of cytochrome P450 in aquatic species. In D. C. Malins & G. K. Ostrander (Eds.), Aquatic toxicology; molecular, biochemical and cellular perspectives (pp. 87–206). Boca Raton: Lewis Publishers, CRC press.

    Google Scholar 

  • Suh, K. S., Choi, E. M., Rhee, S. Y., Oh, S., Kim, S. W., Pak, Y. K., et al. (2017). Tetrabromobisphenol a induces cellular damages in pancreatic β-cells in vitro. Journal of Environmental Science and Health, Part A, 52, 624–631.

    Article  CAS  Google Scholar 

  • Sun, J., Covaci, A., Bustnes, J. O., Jaspers, V. L. B., Helander, B., Bårdsen, B.-J., et al. (2020). Temporal trends of legacy organochlorines in different white-tailed eagle (haliaeetus albicilla) subpopulations: A retrospective investigation using archived feathers. Environment International, 138, 105618.

    Article  CAS  Google Scholar 

  • Svendsen, T., Vorkamp, K., Svendsen, J., Aarestrup, K., & Frier, J.-O. (2009). Organochlorine fingerprinting to determine foraging areas of sea-ranched Atlantic salmon: A case study from Denmark. North American Journal of Fisheries Management, 29, 598–603.

    Article  Google Scholar 

  • 't Mannetje, A., Eng A., Walls C., Dryson E., McLean D., Kogevinas M., Fowles J., Borman B., O’Connor P., Cheng S., Brooks C., Smith A.H., Pearce N., 2016. Serum concentrations of chlorinated dibenzo-p-dioxins, furans and PCBs, among former phenoxy herbicide production workers and firefighters in New Zealand. International Archives of Occupational and Environmental Health 89, 307–318.

    Article  CAS  Google Scholar 

  • Tanabe, S., Kannan, N., Subramanian, A., Watanabe, S., & Tatsukawa, R. (1987). Highly toxic coplanar PCBs: Occurrence, source, persistency and toxic implications to wildlife and humans. Environmental Pollution, 47, 147–163.

    Article  CAS  Google Scholar 

  • Tanabe, S., Watanabe, S., Kan, H., & Tatsukawa, R. (1988). Capacity and mode of PCB metabolism in small cetaceans. Marine Mammal Science, 4, 103–124.

    Article  Google Scholar 

  • Tang, L.-L., Wang, J.-D., Xu, T.-T., Zhao, Z., Zheng, J.-J., Ge, R.-S., et al. (2017). Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes. Toxicology, 382, 108–116.

    Article  CAS  Google Scholar 

  • Tao, L., Zhang, Y., Wu, J.-P., Wu, S.-K., Liu, Y., Zeng, Y.-H., et al. (2019). Biomagnification of pbdes and alternative brominated flame retardants in a predatory fish: Using fatty acid signature as a primer. Environment International, 127, 226–232.

    Article  CAS  Google Scholar 

  • Thornton, J. W., McCally, M., & Houlihan, J. (2002). Biomonitoring of industrial pollutants: Health and policy implications of the chemical body burden. Public Health Reports, 117(2), 315–323.

    Article  Google Scholar 

  • Torres, L., & August, A. (2018). Does perfluorooctane sulfonic acid (pfos) affect the mouse immune system? The FASEB Journal, 32, lb565.

    Article  Google Scholar 

  • Tsukimori, K., Uchi, H., Mitoma, C., Yasukawa, F., Chiba, T., Todaka, T., et al. (2012). Maternal exposure to high levels of dioxins in relation to birth weight in women affected by yusho disease. Environment International, 38, 79–86.

    Article  CAS  Google Scholar 

  • Tue, N. M., Takahashi, S., Subramanian, A., Sakai, S., & Tanabe, S. (2013). Environmental contamination and human exposure to dioxin-related compounds in e-waste recycling sites of develo** countries. Environmental Science: Processes & Impacts, 15, 1326–1331.

    Google Scholar 

  • Tue, N. M., Goto, A., Takahashi, S., Itai, T., Asante, K. A., Kunisue, T., et al. (2016). Release of chlorinated, brominated and mixed halogenated dioxin-related compounds to soils from open burning of e-waste in agbogbloshie (Accra, Ghana). Journal of Hazardous Materials, 302, 151–157.

    Article  CAS  Google Scholar 

  • Tuomisto, J. (2019). Dioxins and dioxin-like compounds: Toxicity in humans and animals, sources, and behaviour in the environment. Wiki Journal of Medicine., 6, 8.

    Article  Google Scholar 

  • Turner, A. (2001). The influence of salting out on the sorption of neutral organic compounds in estuaries. Water Research, 35(18) Elsevier Science, 4379–89.

    Article  Google Scholar 

  • van den Berg, M., Kypke, K., Kotz, A., Tritscher, A., Lee, S. Y., Magulova, K., et al. (2017). Who/unep global surveys of pcdds, pcdfs, pcbs and ddts in human milk and benefit–risk evaluation of breastfeeding. Archives of Toxicology, 91, 83–96.

    Article  Google Scholar 

  • Vorderstrasse, B. A., Bohn, A. A., & Lawrence, B. P. (2003). Examining the relationship between impaired host resistance and altered immune function in mice treated with tcdd. Toxicology, 188, 15–28.

    Article  CAS  Google Scholar 

  • Vos, J. G., Becher, G., Berg, M. V. D., Boer, J. D., & Leonards, P. E. G. (2003). Brominated flame retardants and endocrine disruption. Pure and Applied Chemistry, 75, 2039.

    Article  CAS  Google Scholar 

  • Walters, D., Jardine, T., Cade, B., Kidd, K., Muir, D., & Leipzig-Scott, P. (2016). Trophic magnification of organic chemicals: A global synthesis. Environmental Science & Technology, 50, 4650.

    Article  CAS  Google Scholar 

  • Wang, W., Abualnaja, K. O., Asimakopoulos, A. G., Covaci, A., Gevao, B., Johnson-Restrepo, B., et al. (2015a). A comparative assessment of human exposure to tetrabromobisphenol a and eight bisphenols including bisphenol a via indoor dust ingestion in twelve countries. Environment International, 83, 183–191.

    Article  CAS  Google Scholar 

  • Wang, Y., Liu, W., Zhang, Q., Zhao, H., & Quan, X. (2015b). Effects of developmental perfluorooctane sulfonate exposure on spatial learning and memory ability of rats and mechanism associated with synaptic plasticity. Food and Chemical Toxicology, 76, 70–76.

    Article  Google Scholar 

  • Wang, Z., Hang, J. G., Feng, H., Shi, L. L., Dong, J. J., Shen, B., et al. (2019a). Effects of perinatal dioxin exposure on development of children: A 3-year follow-up study of China cohort. Environmental Science and Pollution Research, 26, 20780–20786.

    Article  CAS  Google Scholar 

  • Wang, S., Hu, X., & Li, X. (2019b). Sub-chronic exposure to tris(1,3-dichloro-2-propyl) phosphate induces sex-dependent hepatotoxicity in rats. Environmental Science and Pollution Research, 26, 33351–33362.

    Article  CAS  Google Scholar 

  • Warner, M., Mocarelli, P., Samuels, S., Needham, L., Brambilla, P., & Eskenazi, B. (2011). Dioxin exposure and cancer risk in the seveso women’s health study. Environmental Health Perspectives, 119, 1700–1705.

    Article  CAS  Google Scholar 

  • Weisglas-Kuperus, N., Vreugdenhil, H. J. I., & Mulder, P. G. H. (2004). Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in dutch school children. Toxicology Letters, 149, 281–285.

    Article  CAS  Google Scholar 

  • West, J. E., O’Neill, S. M., & Ylitalo, G. M. (2017). Time trends of persistent organic pollutants in benthic and pelagic indicator fishes from puget sound, Washington, USA. Archives of Environmental Contamination and Toxicology, 73, 207–229.

    Article  CAS  Google Scholar 

  • White, S. S., Calafat, A. M., Kuklenyik, Z., Villanueva, L., Zehr, R. D., Helfant, L., et al. (2006). Gestational pfoa exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicological Sciences, 96, 133–144.

    Article  Google Scholar 

  • Winkens, K., Vestergren, R., Berger, U., & Cousins, I. T. (2017). Early life exposure to per- and polyfluoroalkyl substances (pfass): A critical review. Emerging Contaminants, 3, 55–68.

    Article  Google Scholar 

  • Wong, M. H., & Poon, B. H. T. (2003). Sources, fates and effects of persistent organic pollutants in China, with emphasis on the pearl river delta. In H. Fiedler (Ed.), Persistent organic pollutants (pp. 355–369). Berlin, Heidelberg: Springer Berlin Heidelberg.

    Chapter  Google Scholar 

  • Wu, L., Ru, H., Ni, Z., Zhang, X., **e, H., Yao, F., et al. (2019). Comparative thyroid disruption by o,p’-ddt and p,p’-dde in zebrafish embryos/larvae. Aquatic Toxicology, 216, 105280.

    Article  CAS  Google Scholar 

  • Xu, W., Wang, X., & Cai, Z. (2013). Analytical chemistry of the persistent organic pollutants identified in the Stockholm convention: A review. Analytica Chimica Acta, 790, 1–13.

    Article  CAS  Google Scholar 

  • Xu, J., Ye, Y., Huang, F., Chen, H., Wu, H., Huang, J., Hu, J., **a, D., & Wu, Y. (2016). Association between dioxin and cancer incidence and mortality: A meta-analysis. Scientific Reports, 6(2016), 38012.

    Article  CAS  Google Scholar 

  • Yeung, L. W. Y., Loi, E. I. H., Wong, V. Y. Y., Guruge, K. S., Yamanaka, N., Tanimura, N., et al. (2009). Biochemical responses and accumulation properties of long-chain perfluorinated compounds (pfos/pfda/pfoa) in juvenile chickens (gallus gallus). Archives of Environmental Contamination and Toxicology, 57, 377–386.

    Article  CAS  Google Scholar 

  • Yilmaz, B., Terekeci, H., Sandal, S., & Kelestimur, F. (2020). Endocrine disrupting chemicals: Exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Reviews in Endocrine and Metabolic Disorders, 21, 127–147.

    Article  CAS  Google Scholar 

  • Yu, L., Lam, J. C. W., Guo, Y., Wu, R. S. S., Lam, P. K. S., & Zhou, B. (2011). Parental transfer of polybrominated diphenyl ethers (pbdes) and thyroid endocrine disruption in zebrafish. Environmental Science & Technology, 45, 10652–10659.

    Article  CAS  Google Scholar 

  • Zeng, H.-c., Zhang, L., Li, Y.-y., Wang, Y.-j., **a, W., Lin, Y., et al. (2011). Inflammation-like glial response in rat brain induced by prenatal pfos exposure. Neurotoxicology, 32, 130–139.

    Article  CAS  Google Scholar 

  • Zeng, Z., Song, B., **ao, R., Zeng, G., Gong, J., Chen, M., et al. (2019). Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies. Environment International, 126, 598–610.

    Article  CAS  Google Scholar 

  • Zhang, Y.-H., Wang, J., Dong, G.-H., Liu, M.-M., Wang, D., Zheng, L., et al. (2013). Mechanism of perfluorooctanesulfonate (pfos)-induced apoptosis in the immunocyte. Journal of Immunotoxicology, 10, 49–58.

    Article  Google Scholar 

  • Zhang, N., Wang, W. S., Li, W. J., Liu, C., Wang, Y., & Sun, K. (2015). Reduction of progesterone, estradiol and hcg secretion by perfluorooctane sulfonate via induction of apoptosis in human placental syncytiotrophoblasts. Placenta, 36, 575–580.

    Article  CAS  Google Scholar 

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Thilagam, H., Gopalakrishnan, S. (2022). Environmental Deterioration Due to Existing and Emerging Persistent Organic Pollutants: An Overview. In: Vasanthy, M., Sivasankar, V., Sunitha, T.G. (eds) Organic Pollutants. Emerging Contaminants and Associated Treatment Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-72441-2_3

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