Abstract
In modern pharmaceutical research practice an everincreasing emphasis is being placed on studies of drug dynamics, that is, the absorption, distribution, metabolism, and elimination of an administered drug. Radiocarbon labeling can be one of the most valuable tools for such studies, provided that the drug to be studied can be synthesized containing the radiocarbon label. Fortunately, for one very large class of organic compounds of physiological interest, the N-methyl-amines, a wide variety of labeling procedures are available. Indeed, among the earliest of radiocarbon-labeled drugs to be prepared were meperidine-N-methyl-C14 (1), dimethylaminoazobenzene-N-methyl-C14 (2), and morphine-N-methyl-C14 (3).
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McMahon, R.E., Marshall, F.J. (1968). The Preparation of N-Methyl-C14-Labeled Drugs. In: Rothchild, S. (eds) Advances in Tracer Methodology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7532-6_3
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DOI: https://doi.org/10.1007/978-1-4684-7532-6_3
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