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Quantitative Mammalian Cell Genetic Toxicology: Study of the Cytotoxicity and Mutagenicity of Seventy Individual Environmental Agents Related to Energy Technologies and Three Subfractions of a Crude Synthetic Oil in the CHO/HGPRT System

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Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures

Part of the book series: Environmental Science Research ((ESRH,volume 15))

Abstract

As science and technology advance, an extraordinary-quantity of natural and synthetic chemicals is introduced continuously into our environment. Through conventional animal tests, some of these environmental chemicals have been found to be either highly toxic, mutagenic, carcinogenic, or teratogenic. Epidemiological studies have shown that among these harmful chemicals, a few also exhibit such detrimental effects in the human population. Because of the high cost and length of time required for the animal experiments, such tests have been confined to only a very small fraction of these environmental agents. Thus, the biological effects of the great majority of these chemicals, including ingredients of our daily foods and drugs, remain either incompletely tested or unknown.

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Author information

Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Graduate School of Biomedical Sciences, University of Tennessee-Oak Ridge, Oak Ridge, Tennessee, USA

    Abraham W. Hsie, J. Patrick O’Neill, Juan R. San Sebastian, David B. Couch, Patricia A. Brimer, William N. C. Sun, James C. Fuscoe, Nancy L. Forbes, Richard Machanoff, James C. Riddle & Mayphoon H. Hsie

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  1. Abraham W. Hsie
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  2. J. Patrick O’Neill
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  3. Juan R. San Sebastian
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  4. David B. Couch
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  5. Patricia A. Brimer
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  6. William N. C. Sun
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  7. James C. Fuscoe
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  8. Nancy L. Forbes
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  9. Richard Machanoff
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  10. James C. Riddle
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  11. Mayphoon H. Hsie
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Michael D. Waters , Stephen Nesnow , Joellen L. Huisingh , Shahbeg S. Sandhu  & Larry Claxton , , ,  & 

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Hsie, A.W. et al. (1978). Quantitative Mammalian Cell Genetic Toxicology: Study of the Cytotoxicity and Mutagenicity of Seventy Individual Environmental Agents Related to Energy Technologies and Three Subfractions of a Crude Synthetic Oil in the CHO/HGPRT System. In: Waters, M.D., Nesnow, S., Huisingh, J.L., Sandhu, S.S., Claxton, L. (eds) Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures. Environmental Science Research, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3611-2_12

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  • DOI: https://doi.org/10.1007/978-1-4684-3611-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3613-6

  • Online ISBN: 978-1-4684-3611-2

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